{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T00:55:52Z","timestamp":1772844952588,"version":"3.50.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<sec><title>BACKGROUND<\/title>TB remains a significant global health challenge, particularly for children, who are often more susceptible to severe disease and complications.<\/sec><sec><title>METHODS<\/title>This study provides a\n comprehensive analysis of TB epidemiology and treatment outcomes in people under 18 years of age in Kazakhstan between 2018 and 2023, utilising a nationwide database that covers the entire country, with a focus on drug-susceptible (DS-TB) and drug-resistant TB (DR-TB) cases.<\/sec><sec><title>RESULTS<\/title>During\n the study period, 3,317 pediatric TB cases were registered, with 76% being DS-TB and a significant proportion being girls and adolescents over 15 years of age. Our findings show a declining trend in TB notification and prevalence from 2018 to 2020, followed by a plateau in subsequent years.\n According to the data, young children under 5 years of age had the lowest TB caseload. Logistic regression analysis revealed that adolescents of 15-17 years of age had higher odds of unsuccessful treatment, while DR-TB patients had better outcomes than DS-TB patients.<\/sec><sec><title>CONCLUSION<\/title>The\n study highlights the need for targeted interventions, improved diagnostic capabilities, and continuous public health efforts to address the burden of TB in children, especially in high-risk regions.<\/sec><\/jats:p>","DOI":"10.5588\/ijtld.24.0536","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:33:45Z","timestamp":1741350825000},"page":"135-140","source":"Crossref","is-referenced-by-count":1,"title":["Epidemiology, detection, diagnosis and treatment of TB in children in Kazakhstan"],"prefix":"10.5588","volume":"29","author":[{"given":"O.","family":"Prikhodchenko","sequence":"first","affiliation":[{"name":"National Scientific Center of Phthisiopulmonology, Ministry of Health of the Republic of Kazakhstan, Almaty, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Arbuzova","sequence":"additional","affiliation":[{"name":"Grant Project Implementation Unit of the Global Fund to Fight AIDS, Tuberculosis, and Malaria, \u2018Tuberculosis\u2019 Component, NSCP of the Republic of Kazakhstan, Almaty, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Serikbayeva","sequence":"additional","affiliation":[{"name":"National Scientific Center of Phthisiopulmonology, Ministry of Health of the Republic of Kazakhstan, Almaty, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Zhakhina","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rakisheva","sequence":"additional","affiliation":[{"name":"Kazakh National Medical University named after S.D. Asfendiyarov, Almaty, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mussabekova","sequence":"additional","affiliation":[{"name":"Grant Project Implementation Unit of the Global Fund to Fight AIDS, Tuberculosis, and Malaria, \u2018Tuberculosis\u2019 Component, NSCP of the Republic of Kazakhstan, Almaty, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Akhmedullin","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tursynbayeva","sequence":"additional","affiliation":[{"name":"Public Union \u2018Kazakhstan Association of Phthisiopulmonologists, \u2019 Almaty, Kazakhstan."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gaipov","sequence":"additional","affiliation":[{"name":"Department of Medicine, School of Medicine, Nazarbayev University, Astana, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Adenov","sequence":"additional","affiliation":[{"name":"National Scientific Center of Phthisiopulmonology, Ministry of Health of the Republic of Kazakhstan, Almaty, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ismailov","sequence":"additional","affiliation":[{"name":"Grant Project Implementation Unit of the Global Fund to Fight AIDS, Tuberculosis, and Malaria, \u2018Tuberculosis\u2019 Component, NSCP of the Republic of Kazakhstan, Almaty, Kazakhstan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2025\/00000029\/00000003\/art00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T12:34:07Z","timestamp":1741350847000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.24.0536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,1]]}},"alternative-id":["1027-3719(20250301)29:3L.135;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.24.0536","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3,1]]}}}