{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T05:10:02Z","timestamp":1751087402248,"version":"3.41.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2025,6,27]]},"abstract":"<sec><title>BACKGROUND<\/title>The \u2018CaP-TB\u2019 project enhanced paediatric TB care through decentralized services, including screening, specimen collection, chest X-rays and implementation of the three-month rifampicin-isoniazid regimen for TB preventive\n treatment (TPT). In Cameroon and Uganda, it also included community-based child contact management through the \u2018CONTACT\u2019 study. We assessed the impact of CaP-TB project on TB detection and TPT outcomes in children, focusing on facilities included in \u2018CONTACT\u2019 study.<\/sec><sec><title>METHODS<\/title>Using\n a before-after design with aggregated data, we compared the proportion of children among all notified TB patients and the TPT completion rate for child contacts <5 years old between a pre- (March 2018\u2013March 2019) and per-intervention (September 2020\u2013September 2021) periods.\n During the intervention, half of the facilities implemented community-based child contact management.<\/sec><sec><title>RESULTS<\/title>The proportion of children among all notified TB patients increased from 4.8% (113\/2373) to 11% (276\/2512) during the intervention\n (odds ratio [OR] = 2.25, 95% confidence interval [CI]: 1.79\u20132.84). The number of children initiated on TPT increased from 105 to 841 and TPT completion rate from 55.2% (58\/105) to 94.9% (798\/841), (OR = 33.4, CI: 16.39\u201368.06).<\/sec><sec><title>CONCLUSION<\/title>Decentralizing\n and strengthening diagnosis and contact management can help overcome barriers to effective TB detection and TPT coverage in children.<\/sec><\/jats:p>","DOI":"10.5588\/ijtld.24.0573","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T04:30:50Z","timestamp":1751085050000},"page":"312-317","source":"Crossref","is-referenced-by-count":0,"title":["Decentralising TB diagnosis and contact management: impact on detection and preventive treatment in children"],"prefix":"10.5588","volume":"29","author":[{"given":"V.","family":"Delmas","sequence":"first","affiliation":[{"name":"TransVIHMI, University Montpellier, IRD, INSERM, Montpellier, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Vasiliu","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine, Department of Pediatrics, Global TB Program, Houston, United States;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Tchakount\u00e9 Youngui","sequence":"additional","affiliation":[{"name":"TransVIHMI, University Montpellier, IRD, INSERM, Montpellier, France;, Elizabeth Glaser Pediatric AIDS Foundation, Research department, Yaound\u00e9, Cameroon;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Ssekyanzi","sequence":"additional","affiliation":[{"name":"Epicentre, Research department, Mbarara, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kuate Kuate","sequence":"additional","affiliation":[{"name":"National Tuberculosis Control Program, Case management and training, Yaound\u00e9, Cameroon;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Turyahabwe","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Program, National Tuberculosis Control Program, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Simo","sequence":"additional","affiliation":[{"name":"Elizabeth Glaser Pediatric AIDS Foundation, Research department, Yaound\u00e9, Cameroon;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Okello","sequence":"additional","affiliation":[{"name":"Elizabeth Glaser Pediatric AIDS Foundation, CaP-TB project, Mbarara, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Casenghi","sequence":"additional","affiliation":[{"name":"Elizabeth Glaser Pediatric AIDS Foundation, CaP-TB project, Geneva, Switzerland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.K.","family":"Tchounga","sequence":"additional","affiliation":[{"name":"Elizabeth Glaser Pediatric AIDS Foundation, Research department, Yaound\u00e9, Cameroon;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Atwine","sequence":"additional","affiliation":[{"name":"Elizabeth Glaser Pediatric AIDS Foundation, Research department, Yaound\u00e9, Cameroon;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Cuer","sequence":"additional","affiliation":[{"name":"TransVIHMI, University Montpellier, IRD, INSERM, Montpellier, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bonnet","sequence":"additional","affiliation":[{"name":"TransVIHMI, University Montpellier, IRD, INSERM, Montpellier, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2025\/00000029\/00000007\/art00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T04:30:52Z","timestamp":1751085052000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.24.0573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,6,27]]}},"alternative-id":["1027-3719(20250627)29:7L.312;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.24.0573","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,27]]}}}