{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T23:46:38Z","timestamp":1780616798537,"version":"3.54.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2025,6,27]]},"abstract":"<sec><title>BACKGROUND<\/title>Digital adherence technologies such as 99DOTS are being scaled-up for TB treatment despite limited evidence of their effectiveness and concerns about accessibility. We evaluated the reach and effectiveness of 99DOTS during its scale-up\n in Uganda.<\/sec><sec><title>METHODS<\/title>We included all adults initiating drug-susceptible pulmonary TB treatment between August 2019 to June 2021 at 12 99DOTS-na\u00efve health facilities (n = 3,526). Using an interrupted time series design, we compared\n the proportion with treatment success (primary outcome) and enrolled on 99DOTS in the 9 months before and 12 months after implementing an \u2018enhanced 99DOTS\u2019 intervention. This included providing low-cost phones to people with TB when needed, task shifting monitoring and support\n to community health workers, and automated task lists. Treatment data were derived from routine TB treatment registers.<\/sec><sec><title>RESULTS<\/title>The proportion enrolled on 99DOTS post-intervention was high (87.2%) and had a slight upward trend (proportion\n ratio 1.01, 95% CI 1.00\u20131.01). Treatment completion remained similar across periods (89.8% post-intervention vs. 87.1% pre-intervention). There was no immediate level or slope change in treatment success following the intervention.<\/sec><sec><title>CONCLUSIONS<\/title>With\n appropriate implementation supports, 99DOTS can have high uptake without negatively impacting treatment outcomes. Equity in access should be prioritized during implementation.<\/sec><\/jats:p>","DOI":"10.5588\/ijtld.24.0587","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T04:30:50Z","timestamp":1751085050000},"page":"306-311","source":"Crossref","is-referenced-by-count":3,"title":["Scale-up of 99DOTS for TB treatment supervision: an interrupted time series analysis"],"prefix":"10.5588","volume":"29","author":[{"given":"R.","family":"Crowder","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, USA;, Center for Tuberculosis, University of California San Francisco, San Francisco, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nakasendwa","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kityamuwesi","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Musoke","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nannozi","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Waswa","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.N.","family":"Sanyu","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lamunu","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Twinamasiko","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.K.","family":"Tinka","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Oyuku","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Babirye","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, USA;, Center for Tuberculosis, University of California San Francisco, San Francisco, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Turyahabwe","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Program, Uganda Ministry of Health, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Dowdy","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Katamba","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;, Clinical Epidemiology & Biostatistics Unit, Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cattamanchi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, USA;, Center for Tuberculosis, University of California San Francisco, San Francisco, USA;, Uganda Tuberculosis\n Implementation Research Consortium, Kampala, Uganda;, Division of Pulmonary Diseases and Critical Care Medicine, University of California Irvine, Irvine, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Kiwanuka","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;, Department of Epidemiology and Biostatistics, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2025\/00000029\/00000007\/art00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T04:30:51Z","timestamp":1751085051000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.24.0587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,27]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,6,27]]}},"alternative-id":["1027-3719(20250627)29:7L.306;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.24.0587","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6,27]]}}}