{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T06:39:05Z","timestamp":1775284745834,"version":"3.50.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2025,8,29]]},"abstract":"<jats:p>&lt;sec&gt;&lt;title&gt;BACKGROUND&lt;\/title&gt;Adolescents (ages 10\u201319) affected by TB face unique challenges to completing TB treatment. Digital adherence technologies (DATs) may be a useful tool for TB treatment monitoring. In this study, we assessed whether 99DOTS, a low-cost\n DAT, could improve treatment outcomes among adolescents with pulmonary TB (PTB).&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;METHODS&lt;\/title&gt;We conducted an interrupted time series (ITS) analysis of adolescents initiating treatment for drug-susceptible PTB at 30 health facilities in Uganda.\n ITS analysis was used to model the change in TB treatment outcomes and loss to follow-up in adolescents prior to and after the implementation of a 99DOTS-based intervention.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;RESULTS&lt;\/title&gt;Of 630 adolescents, 78.4% of adolescents were enrolled\n on 99DOTS in the post-intervention period. In the adjusted analysis, the proportion treated successfully increased (level change, proportion ratio [PR] 1.18, 95% confidence interval [CI] 1.08\u20131.28) and the proportion lost to follow-up decreased (level change, PR 0.93, 95% CI 0.88\u20130.98)\n in the immediate post-intervention period. Both proportions remained similar throughout the post-intervention period (<jats:italic>P<\/jats:italic> value for slope change &gt;0.05).&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;CONCLUSION&lt;\/title&gt;There was a high uptake of 99DOTS among adolescents with TB, and\n use of 99DOTS was associated with improved treatment outcomes. DATs should be further explored as a promising adolescent-specific tool for improving TB treatment outcomes.&lt;\/sec&gt;<\/jats:p>","DOI":"10.5588\/ijtld.24.0663","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T04:35:43Z","timestamp":1756528543000},"page":"404-409","source":"Crossref","is-referenced-by-count":1,"title":["Use of a digital adherence technology to support TB treatment among adolescents"],"prefix":"10.5588","volume":"29","author":[{"given":"A.M.","family":"Schraufnagel","sequence":"first","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Crowder","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA;, Center for Tuberculosis, University of California San Francisco, San Francisco, CA, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Wambi","sequence":"additional","affiliation":[{"name":"Mulago National Referral Hospital, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Nakasendwa","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Kityamuwesi","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Jaganath","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA;, Center for Tuberculosis, University of California San Francisco, San Francisco, CA, USA;, Division\n of Pediatric Infectious Diseases, University of California, San Francisco, San Francisco, CA, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Musoke","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Nannozi","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Waswa","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.N.","family":"Sanyu","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lamunu","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Twinamasiko","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.K.","family":"Tinka","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Oyuku","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Babirye","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Berger","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA;, Center for Tuberculosis, University of California San Francisco, San Francisco, CA, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Turyahabwe","sequence":"additional","affiliation":[{"name":"National Tuberculosis and Leprosy Program, Uganda Ministry of Health, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Dowdy","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;, Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Katamba","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;, Clinical Epidemiology and Biostatistics Unit, Department of Medicine, Makerere University College of Health Sciences, Kampala, Uganda;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cattamanchi","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA, USA;, Center for Tuberculosis, University of California San Francisco, San Francisco, CA, USA;, Uganda\n Tuberculosis Implementation Research Consortium, Kampala, Uganda;, Division of Pulmonary Diseases and Critical Care Medicine, University of California Irvine, Irvine, CA, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kiwanuka","sequence":"additional","affiliation":[{"name":"Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda;, Department of Epidemiology and Biostatistics, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung 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