{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:19:11Z","timestamp":1787635151019,"version":"build-2736575974"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2025,9,26]]},"abstract":"<jats:p>&lt;sec&gt;&lt;title&gt;BACKGROUND&lt;\/title&gt;Children are at risk of TB, especially if they are household contacts of someone newly diagnosed. Research is needed on outcome of paediatric household contacts of drug-resistant TB (DR-TB) index patients, where routine follow-up is\n usually offered instead of preventive treatment. We describe the yield of a contact investigation protocol implemented among children ages 0\u201314 years living with DR-TB patients.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;METHODS&lt;\/title&gt;A single centre prospective cohort study was\n conducted to follow-up paediatric household contacts of newly diagnosed (within last 6 months) sputum-positive pulmonary DR-TB patients in New Delhi, India. The study conducted symptom screening, tuberculin skin testing, chest X-rays, and bacteriological testing at baseline and during the\n 1-year follow-up.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;RESULTS&lt;\/title&gt;We found a high yield of TB disease at baseline and within the first four follow-up months, with 22\/276 participants (8.0%) started on TB treatment. Of these 22, 7 were bacteriologically confirmed and 15 were\n clinically diagnosed. Of the 7 participants with bacteriologically confirmed TB, 5 were asymptomatic, suggesting symptom screening alone may not be effective.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;CONCLUSION&lt;\/title&gt;We advocate for early screening and diagnosis coupled with TB preventive\n treatment, instead of rigorous follow-ups as means of preventing paediatric DR-TB in household contacts.&lt;\/sec&gt;<\/jats:p>","DOI":"10.5588\/ijtld.25.0081","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T16:34:05Z","timestamp":1766075645000},"page":"455-461","source":"Crossref","is-referenced-by-count":0,"title":["Yield of a contact investigation among children living with drug-resistant TB patients"],"prefix":"10.5588","volume":"29","author":[{"given":"S.","family":"Sharma","sequence":"first","affiliation":[{"name":"National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Patankar","sequence":"additional","affiliation":[{"name":"College of Arts and Sciences, Harvard University, Cambridge, MA, USA;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Becerra","sequence":"additional","affiliation":[{"name":"Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bhalla","sequence":"additional","affiliation":[{"name":"National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.U.","family":"Khayyam","sequence":"additional","affiliation":[{"name":"National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sethi","sequence":"additional","affiliation":[{"name":"National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Furin","sequence":"additional","affiliation":[{"name":"Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2025\/00000029\/00000010\/art00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:31:22Z","timestamp":1787632282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.25.0081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,9,26]]}},"alternative-id":["1027-3719(20250926)29:10L.455;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.25.0081","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9,26]]}}}