{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:56:05Z","timestamp":1790672165277,"version":"4.1.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2025,9,26]]},"abstract":"<jats:p>&lt;sec&gt;&lt;title&gt;BACKGROUND&lt;\/title&gt;Linezolid is effective against multidrug-resistant TB (MDR-TB) but is frequently associated with adverse events that limit long-term use. However, data on the clinical outcomes following linezolid-related adverse events among patients\n with MDR-TB remain limited.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;METHODS&lt;\/title&gt;This retrospective multicentre study in Japan comprised 81 patients with MDR-TB who developed linezolid-related adverse events during treatment with an initial standard dose of linezolid (600 mg).&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;RESULTS&lt;\/title&gt;Peripheral\n neuropathy, hematotoxicity, and optic neuropathy were the most frequent adverse events. Most patients with hematotoxicity improved with linezolid discontinuation or dose reduction. However, 20 of 44 patients (45%) with peripheral neuropathy and 2 out of 11 patients (18%) with optic neuropathy\n did not improve after 1 year of discontinuation. A longer duration from the onset of neuropathy to discontinuation and higher total dosage from the onset to discontinuation were risk factors for both residual peripheral neuropathy and optic neuropathy. Among the patients who discontinued linezolid\n owing to hematotoxicity, the recurrence rate was 19% (3\/16) in those who re-administered linezolid at a low dose (300 mg).&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;CONCLUSION&lt;\/title&gt;If peripheral neuropathy or optic neuropathy occurs, continuous administration of linezolid may lead\n to long-term residual neuropathies. Re-administration of low-dose linezolid may be considered in cases of hematotoxicity.&lt;\/sec&gt;<\/jats:p>","DOI":"10.5588\/ijtld.25.0125","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T16:34:05Z","timestamp":1766075645000},"page":"462-468","source":"Crossref","is-referenced-by-count":3,"title":["Clinical outcomes of linezolid-related adverse events in patients with multidrug-resistant TB"],"prefix":"10.5588","volume":"29","author":[{"given":"T.","family":"Kodama","sequence":"first","affiliation":[{"name":"Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan;, Department of Basic Mycobacteriosis, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan;, Department of Mycobacterium Reference\n and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Center of Pulmonary Disease, National Hospital Organization Tokyo National Hospital, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Tsuyuguchi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Clinical Research Center, National Hospital Organization Kinki Chuo Chest Medical Center, Sakai, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Okumura","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kamada","sequence":"additional","affiliation":[{"name":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Yamane","sequence":"additional","affiliation":[{"name":"Center of Pulmonary Disease, National Hospital Organization Tokyo National Hospital, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Higashinagoya National Hospital, Nagoya, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Wakamatsu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Omuta National Hospital, Fukuoka, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Nagara Medical Center, Gifu, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Koreeda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Minamikyushu Hospital, Kagoshima, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kuwabara","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Nishi-Niigata Chuo Hospital, Niigata, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Amishima","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, National Hospital Organization Hokkaido Medical Center, Hokkaido, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tamaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Hospital Organization Nara Medical Center, Nara, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Takaki","sequence":"additional","affiliation":[{"name":"Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kato","sequence":"additional","affiliation":[{"name":"Director\u2019s Office, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nagai","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, National Hospital Organization, Tokyo National Hospital, Tokyo, Japan."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mitarai","sequence":"additional","affiliation":[{"name":"Department of Basic Mycobacteriosis, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan;, Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association,\n Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Yoshiyama","sequence":"additional","affiliation":[{"name":"Respiratory Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association, Tokyo, Japan;, Director\u2019s Office, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Tokyo, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung 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