{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T04:33:51Z","timestamp":1767414831310,"version":"3.48.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:p>&lt;sec&gt;&lt;title&gt;BACKGROUND&lt;\/title&gt;Mortality from inpatient TB\/HIV is high, and C-reactive protein (CRP) is a suboptimal triaging test. Haemoglobin and albumin and may have additional utility.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;METHODS&lt;\/title&gt;We enrolled\n hospitalised adults evaluated for presumptive TB\/HIV and used optimised cut-off values to determine the performance of CRP, haemoglobin, and albumin in triaging for TB\/HIV after urine lipoarabinomannan (LAM) testing.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;RESULTS&lt;\/title&gt;Four hundred\n and thirty-nine participants were evaluated. Of the 293 participants with complete results, haemoglobin and albumin levels below the cut-off values were independently associated with LAM-positive TB (adjusted odds ratios: 6.1 [95% confidence interval (CI): 2.6; 15.4] and 5.5 [95% CI: 1.6;\n 25.0], respectively), but not CRP above the cut-off value (adjusted odds ratio: 2.2 [95% CI: 0.8; 6.6]). If haemoglobin and albumin cut-offs were met, the odds ratio for LAM-positive TB was 17.0 (95% CI: 7.6; 38.0), sensitivity 0.72 (95% CI: 0.56; 0.84), and specificity 0.86 (95% CI: 0.82;\n 0.91); and the odds ratio was 3.5 (95% CI: 1.4; 8.5) for LAM-negative TB, sensitivity 0.35 (95% CI 0.19; 0.55), and specificity 0.87 (95% CI 0.81; 0.91).&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;CONCLUSION&lt;\/title&gt;Haemoglobin and albumin performed better than CRP as an inpatient TB\/HIV\n triage test.&lt;\/sec&gt;<\/jats:p>","DOI":"10.5588\/ijtld.25.0167","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T04:30:27Z","timestamp":1767414627000},"page":"4-10","source":"Crossref","is-referenced-by-count":0,"title":["Performance of C-reactive protein, haemoglobin, and albumin as TB\/HIV triage tests in hospitalised adults"],"prefix":"10.5588","volume":"30","author":[{"given":"S.T.","family":"Duma","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Harry Gwala Regional Hospital, Pietermaritzburg Hospital Complex, University of KwaZulu-Natal, Durban, South Africa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Dalmat","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, Department of Global Health, University of Washington, Seattle, WA, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Magcaba","sequence":"additional","affiliation":[{"name":"Umkhuseli Innovation and Research Management, Pietermaritzburg, South Africa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X.","family":"Niu","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, Department of Global Health, University of Washington, Seattle, WA, USA;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ngcobo","sequence":"additional","affiliation":[{"name":"Umkhuseli Innovation and Research Management, Pietermaritzburg, South Africa;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.K.","family":"Drain","sequence":"additional","affiliation":[{"name":"International Clinical Research Center, Department of Global Health, University of Washington, Seattle, WA, USA;, School of Medicine, University of Washington, Seattle, WA, USA."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Harry Gwala Regional Hospital, Pietermaritzburg Hospital Complex, University of KwaZulu-Natal, Durban, South Africa;, Umkhuseli Innovation and Research Management, Pietermaritzburg, South Africa;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2026\/00000030\/00000001\/art00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T04:30:28Z","timestamp":1767414628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.25.0167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,2]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,2]]}},"alternative-id":["1027-3719(20260102)30:1L.4;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.25.0167","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1,2]]}}}