{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T05:49:51Z","timestamp":1782884991801,"version":"3.54.5"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:p>&lt;sec&gt;&lt;title&gt;BACKGROUND&lt;\/title&gt;TB meningitis (TBM) is the most severe form of extra-pulmonary TB. This study evaluated the efficacy and safety of adjunctive steroid therapy in TBM.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;METHODS&lt;\/title&gt;We searched PubMed\/MEDLINE,\n Embase, and Cochrane CENTRAL for controlled trials of steroids in TBM. Pooled risk ratios (RRs) with 95% confidence intervals (CIs) were calculated for mortality, neurological complications, functional recovery, and adverse events.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;RESULTS&lt;\/title&gt;Fourteen\n trials with 2,028 patients were included. Steroids reduced mortality in adults (RR = 0.83; 95% CI: 0.72\u20130.95) but not in children (RR = 0.68; 95% CI: 0.36\u20131.29). No significant benefit was seen for neurological complications (RR = 1.03; 95% CI: 0.74\u20131.44) or functional recovery\n (RR = 1.16; 95% CI: 0.86\u20131.57). Results were consistent across steroid types, doses, and routes.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;CONCLUSION&lt;\/title&gt;Adjunctive steroids reduce mortality in adult TBM but not in children, nor do they improve neurological or functional outcomes.&lt;\/sec&gt;<\/jats:p>","DOI":"10.5588\/ijtld.25.0588","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:33:48Z","timestamp":1782794028000},"page":"297-302","source":"Crossref","is-referenced-by-count":0,"title":["A systematic review and meta-analysis of steroid use for treatment of TB meningitis"],"prefix":"10.5588","volume":"30","author":[{"given":"M.J.","family":"Nasiri","sequence":"first","affiliation":[{"name":"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Hamzelouee","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Rezaeinasab","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Souri","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Eghbal","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Ghafari","sequence":"additional","affiliation":[{"name":"Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"D\u2019Ambrosio","sequence":"additional","affiliation":[{"name":"Public Health Consulting Group, Lugano, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Centis","sequence":"additional","affiliation":[{"name":"Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Venketaraman","sequence":"additional","affiliation":[{"name":"College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA, USA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.B.","family":"Migliori","sequence":"additional","affiliation":[{"name":"Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2026\/00000030\/00000007\/art00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:32:58Z","timestamp":1782880378000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.25.0588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,6,29]]}},"alternative-id":["1027-3719(20260629)30:7L.297;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.25.0588","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}