{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:02:30Z","timestamp":1789794150445,"version":"4.0.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:p>&lt;sec&gt;&lt;title&gt;BACKGROUND&lt;\/title&gt;Adherence to TB treatment is crucial for successful outcomes. While facility-based directly observed therapy (FB-DOT) is a common strategy, recognition of its limitations has spurred the development of flexible approaches. We have\n compared the effectiveness of alternative adherence-enhancing strategies with FB-DOT.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;METHODS&lt;\/title&gt;We searched three databases and four registries from June 2013 to May 2025. We included comparative studies evaluating interventions designed\n to improve adherence to TB treatment in people aged 15 years or older, excluding adherence to multiple therapies. Meta-analyses were conducted for treatment success, treatment completion, cure rate, and loss to follow-up.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;RESULTS&lt;\/title&gt;Twenty-five\n studies involving 19,103 participants were included. Self-administered treatment and reminder-based interventions achieved treatment success comparable to FB-DOT. Community-based DOT showed similar cure and completion rates but was effective at reducing loss to follow-up (71% reduction). Video-supported\n treatment and digital adherence technologies demonstrated neutral effects across treatment outcomes. Multicomponent strategies showed heterogeneous results.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;CONCLUSION&lt;\/title&gt;Alternative adherence strategies can offer improvements over FB-DOT\n in specific contexts. However, their variable effectiveness limits universal implementation. Adherence support, community engagement, and social determinants should guide programmatic design and implementation.&lt;\/sec&gt;<\/jats:p>","DOI":"10.5588\/ijtld.25.0604","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:35:32Z","timestamp":1785558932000},"page":"350-357","source":"Crossref","is-referenced-by-count":0,"title":["Comparing adherence strategies and facility DOT in TB care: a systematic review with meta-analysis"],"prefix":"10.5588","volume":"30","author":[{"given":"J.P.","family":"Ramos","sequence":"first","affiliation":[{"name":"EPIUnit ITR, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal;, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Vieira","sequence":"additional","affiliation":[{"name":"EPIUnit ITR, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal;, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Pneumologia, Unidade Local de Sa\u00fade de Matosinhos, Porto, Portugal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.L.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Pneumologia, Unidade Local de Sa\u00fade de Gaia e Espinho, Vila Nova de Gaia, Portugal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Barbosa","sequence":"additional","affiliation":[{"name":"EPIUnit ITR, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal;, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Aguiar","sequence":"additional","affiliation":[{"name":"EPIUnit ITR, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal;, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Duarte","sequence":"additional","affiliation":[{"name":"EPIUnit ITR, Instituto de Sa\u00fade P\u00fablica da Universidade do Porto, Porto, Portugal;, Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Universidade do Porto, Porto, Portugal;, Instituto de Sa\u00fade P\u00fablica Doutor\n Ricardo Jorge - INSA Porto, Porto, Portugal."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2026\/00000030\/00000008\/art00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:32:35Z","timestamp":1789792355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.25.0604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7,31]]}},"alternative-id":["1027-3719(20260731)30:8L.350;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.25.0604","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}