{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:02:31Z","timestamp":1789794151702,"version":"4.0.1"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["int j tuberc lung dis"],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:p>&lt;sec&gt;&lt;title&gt;BACKGROUND&lt;\/title&gt;Two-month smear conversion has been adopted instead of cultures to predict unfavourable bacteriological outcomes in TB treatment. However, this approach is limited by lower sensitivity and specificity.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;OBJECTIVE&lt;\/title&gt;In\n absence of early-stage biomarkers of treatment response, we investigated the association between bacteriological outcome and microscopy data with auramine and fluorescein diacetate stains at baseline and during the first 2 weeks of treatment in the context of the OneRIF trial. This is a secondary\n analysis of data collected during the OneRIF trial.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;RESULTS&lt;\/title&gt;Failure or relapse occurred in 15 patients of 321 treated with double-dose R. Only quantitative baseline auramine significantly predicted failure or relapse: for every 100 bacilli\n per field increase, there was 5% higher odds of having an unfavourable bacteriological outcome.&lt;\/sec&gt;&lt;sec&gt;&lt;title&gt;CONCLUSION&lt;\/title&gt;While quantitative baseline auramine predicted having an unfavourable bacteriological outcome, considering our small data we could\n not identify any added value in implementing quantitative bacillary load in the first 2 weeks of treatment. These findings should be interpreted with caution as we were limited by the relatively low number of failure and relapse.&lt;\/sec&gt;<\/jats:p>","DOI":"10.5588\/ijtld.26.0051","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T04:35:32Z","timestamp":1785558932000},"page":"365-370","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of microscopically quantitative loads of bacilli as early predictors of TB treatment outcome"],"prefix":"10.5588","volume":"30","author":[{"given":"I.","family":"Vellere","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, San Jacopo Hospital, USL Toscana Centro, Pistoia, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.K.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.K.J.","family":"Maug","sequence":"additional","affiliation":[{"name":"Damien Foundation Bangladesh, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Hossain","sequence":"additional","affiliation":[{"name":"Damien Foundation Bangladesh, Dhaka, Bangladesh;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.C.","family":"De Jong","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lynen","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Lorent","sequence":"additional","affiliation":[{"name":"Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Decroo","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","container-title":["The International Journal of Tuberculosis and Lung Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ingentaconnect.com\/content\/iuatld\/ijtld\/2026\/00000030\/00000008\/art00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:32:28Z","timestamp":1789792348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ingentaconnect.com\/content\/10.5588\/ijtld.26.0051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,31]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,7,31]]}},"alternative-id":["1027-3719(20260731)30:8L.365;1-"],"URL":"https:\/\/doi.org\/10.5588\/ijtld.26.0051","relation":{},"ISSN":["1027-3719"],"issn-type":[{"value":"1027-3719","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,31]]}}}