{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:16:11Z","timestamp":1789578971087,"version":"build-2803163510"},"reference-count":32,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJTLD Open"],"accepted":{"date-parts":[[2023,8,11]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:title>SETTING<\/jats:title>\n                    <jats:p>C\u00f4te d'Ivoire is a country with a high incidence of TB. The control of TB infection is focused on high-risk patients but has limited implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE<\/jats:title>\n                    <jats:p>Cost-benefit analysis of TB infection (TBI) screening of household contacts in C\u00f4te d\u2019Ivoire to evaluate economic implications of the implementation of interferon-gamma release assays (IGRAs) and the tuberculin skin test (TST).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DESIGN<\/jats:title>\n                    <jats:p>We compared the effectiveness of QuantiFERON-TB Gold Plus (QuantiFERON) with the TST using an economic model previously evaluated in medium TB incidence settings. Principal outcomes relating to TBI screening, as well as the lifetime costs and benefits of the patient cohort, were captured using a decision tree, followed by a Markov model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>QuantiFERON proved to be both more effective and less costly than TST. Compared to QuantiFERON, TST use leads to an approximate 33% increase in the lifetime risk of developing active TB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS<\/jats:title>\n                    <jats:p>\n                      For household contacts of active TB cases in C\u00f4te d\u2019Ivoire, QuantiFERON is cost-effective when compared with TST.\n                      <jats:italic>R<\/jats:italic>\n                      shiny interactive interface enables model customisation for different scenarios, settings, risk groups and TBI screening methods. Further research should be conducted in similar settings to generalise the results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.5588\/ijtldopen.23.0342","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T23:39:56Z","timestamp":1705361996000},"page":"20-26","source":"Crossref","is-referenced-by-count":6,"title":["Screening of household contacts for TB infection in Cote d'Ivoire"],"prefix":"10.5588","volume":"1","author":[{"given":"R. K.","family":"N\u2019Guessan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. A. B.","family":"Orsot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Ahui Brou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. K.","family":"Bamba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. E.","family":"Tchoutedjem Mefo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. S.","family":"Bakayoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","published-online":{"date-parts":[[2024,1,1]]},"reference":[{"key":"2026011502123664000_1.1.20.1","unstructured":"World Health Organization . Global tuberculosis report, 2022. Geneva, Switzerland: WHO, 2022."},{"key":"2026011502123664000_1.1.20.2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002152"},{"key":"2026011502123664000_1.1.20.3","doi-asserted-by":"crossref","unstructured":"Migliori GB , . The path to TB elimination: a renewed vision. Eur Respir J Eur Respir J 2023 ;61(6):2300499.","DOI":"10.1183\/13993003.00499-2023"},{"key":"2026011502123664000_1.1.20.4","unstructured":"World Health Organization . End TB Strategy. Geneva, Switzerland: WHO, 2015."},{"issue":"3","key":"2026011502123664000_1.1.20.5","doi-asserted-by":"crossref","first-page":"190","DOI":"10.5588\/ijtld.21.0753","article-title":"Clinical standards for the diagnosis, treatment and prevention of TB infection","volume":"26","author":"Migliori","year":"2022","journal-title":"J Tuberc Lung Dis"},{"key":"2026011502123664000_1.1.20.6","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1111\/tmi.13693","article-title":"Prevalence and risk factors associated with latent tuberculosis infection among household contacts of smear positive pulmonary tuberculosis patients in South India","volume":"26","author":"Krishnamoorthy","year":"2021","journal-title":"Trop Med Int Heal"},{"key":"2026011502123664000_1.1.20.7","unstructured":"World Health Organization . WHO operational handbook on tuberculosis. Module 1: Prevention-tuberculosis preventive treatment, 2020. Geneva Switzerland:WHO, 2020."},{"key":"2026011502123664000_1.1.20.8","doi-asserted-by":"publisher","DOI":"10.1016\/0041-3879(76)90059-3"},{"key":"2026011502123664000_1.1.20.9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236743"},{"key":"2026011502123664000_1.1.20.10","doi-asserted-by":"crossref","unstructured":"Cohen A , . The global prevalence of latent tuberculosis: a systematic review and meta-analysis. Eur Respir J 2019;54(3):1900655.","DOI":"10.1183\/13993003.00655-2019"},{"key":"2026011502123664000_1.1.20.11","unstructured":"World Health Organization . Use of alternative interferon-gamma release assays for the diagnosis of TB infection - WHO Policy Statement. Geneva, Switzerland: WHO, 2022."},{"key":"2026011502123664000_1.1.20.12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2048"},{"key":"2026011502123664000_1.1.20.13","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-149-3-200808050-00241"},{"key":"2026011502123664000_1.1.20.14","unstructured":"Qiagen . QuantiFERON-TB Gold Plus (QFT-Plus). Hilden, Germany: Qiagen, 2023."},{"key":"2026011502123664000_1.1.20.15","doi-asserted-by":"crossref","first-page":"e158","DOI":"10.1002\/hsr2.158","article-title":"How are high burden countries implementing policies and tools for latent tuberculosis infection? A survey of current practices and barriers","volume":"3","author":"Faust","year":"2020","journal-title":"Heal Sci Reports"},{"key":"2026011502123664000_1.1.20.16","first-page":"1","article-title":"A cost-effectiveness evaluation of latent tuberculosis infection screening of a migrant population in Malaysia","volume":"13","author":"Barker","year":"2023","journal-title":"Sci Reports"},{"key":"2026011502123664000_1.1.20.17","doi-asserted-by":"publisher","DOI":"10.1186\/S12962-021-00301-8\/TABLES\/5"},{"key":"2026011502123664000_1.1.20.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2019.08.018"},{"key":"2026011502123664000_1.1.20.19","unstructured":"World Health Organization . Life tables by country: Cote d\u2019Ivoire. Geneva, Switzerland: WHO, 2020."},{"key":"2026011502123664000_1.1.20.20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1556\/1886.2018.00001","article-title":"Multidrug-Resistant Tuberculosis in C\u00f4te d\u2019Ivoire from 1995 to 2016: Results of National Surveys","volume":"8","author":"N\u2019Guessan","year":"2018","journal-title":"Eur J Microbiol Immunol"},{"key":"2026011502123664000_1.1.20.21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056044"},{"issue":"1","key":"2026011502123664000_1.1.20.22","first-page":"16","article-title":"Interferon-gamma release assays and TB screening in high-income countries: a cost-effectiveness analysis","volume":"11","author":"Oxlade","year":"2007","journal-title":"Int J Tuberc Lung Dis"},{"key":"2026011502123664000_1.1.20.23","doi-asserted-by":"publisher","DOI":"10.1016\/s1473-3099(22)00153-0"},{"key":"2026011502123664000_1.1.20.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2022.05.029"},{"issue":"1","key":"2026011502123664000_1.1.20.25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s40291-014-0125-0","article-title":"A systematic review on TST and IGRA tests used for diagnosis of LTBI in immigrants","volume":"19","author":"Campbell","year":"2015","journal-title":"Mol Diagn Ther"},{"key":"2026011502123664000_1.1.20.26","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1186\/s12890-022-02149-x","article-title":"A systematic review of cost-utility analyses of screening methods in latent tuberculosis infection in high-risk populations","volume":"22","author":"Mahon","year":"2022","journal-title":"BMC Pulm"},{"key":"2026011502123664000_1.1.20.27","unstructured":"World Health Organization . 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Enqu\u00eate D\u00e9mographique et de Sant\u00e9, 2021. Abidjan, C\u00f4te d\u2019Ivoire: INS, 2021. 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