{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T02:17:24Z","timestamp":1768529844469,"version":"3.49.0"},"reference-count":28,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJTLD Open"],"accepted":{"date-parts":[[2025,7,10]]},"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>At least 1 million adolescents develop TB disease annually. Adolescents are also at risk for depression due to TB, but this is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This prospective cohort study aimed to identify the frequency and risk factors for depression amongst adolescents with rifampicin-susceptible TB in Lima, Peru. During weeks 3\u20135 of treatment, participants completed a survey that included socio-demographic characteristics, symptoms, treatment side effects, and the Patient Health Questionnaire-9 depression scale. Those with depression received psychological evaluation and were referred for treatment, with treatment intensity corresponding to depression severity. Applying k-means cluster analysis, we grouped participants by socio-demographic characteristics. We used generalised linear mixed-effects regression to model the relationship between cluster, symptoms and side effects, and depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of 249 participants, 98 (39%), 62 (25%), and 33 (13%) had mild, moderate, and severe depression, respectively. We identified three clusters; Cluster 1 \u2013 adolescents with lower social support and more prior trauma \u2013 had the highest frequency of depression. Across all clusters, symptoms and side effects correlated with depression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Given their high frequency of depression, adolescents on TB treatment \u2013 particularly those with trauma history, weak social support, or numerous symptoms and side effects \u2013 should be routinely screened for depression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5588\/ijtldopen.25.0305","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T04:34:41Z","timestamp":1763008481000},"page":"639-645","source":"Crossref","is-referenced-by-count":0,"title":["Depression in adolescents on treatment for rifampicin-susceptible TB in Lima, Peru"],"prefix":"10.5588","volume":"2","author":[{"given":"V.","family":"Sanchez-Guzman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Tanzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Roman-Sinche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Santacruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Desrosiers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Lecca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.S.","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","published-online":{"date-parts":[[2025,11,1]]},"reference":[{"key":"2026011502263783000_2.11.639.1","unstructured":"World Health Organization . 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