{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:34:18Z","timestamp":1773876858543,"version":"3.50.1"},"reference-count":26,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJTLD Open"],"accepted":{"date-parts":[[2025,10,12]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      Pulmonary TB is diagnosed by isolating\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      from sputum. Culture conversion, defined as two consecutive negative sputum cultures, guides treatment duration. Non-TB mycobacteria (NTM) species are common in the environment but only cause pulmonary disease in certain patients, and the significance of co-isolation of NTM during TB treatment is unclear. We aimed to assess if NTM co-isolation impacts sputum conversion, treatment duration, or outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We conducted a retrospective study of pulmonary TB patients treated at West Park Healthcare Centre between 2010 and 2020. Demographics, microbiologic data, and clinical outcomes were extracted. Patients with NTM co-isolation were compared to those with TB-alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among 771 patients, 284 co-isolated NTM. These patients were older (median 58 vs. 49 years) and more often had diabetes (28.5% vs. 18.7%). They had longer time to sputum culture conversion (56 vs. 45.5 days) and were less likely to achieve sputum culture conversion (73.1% vs. 82.7%). NTM co-isolated patients had more persistent cough and sputum at treatment completion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>NTM co-isolation in TB occurs more commonly in older patients, and those with diabetes. Patients who co-isolate NTM during TB treatment are less likely to culture convert, have a longer time to culture conversion, and have more end-of-treatment symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5588\/ijtldopen.25.0539","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T16:11:17Z","timestamp":1773850277000},"page":"163-168","source":"Crossref","is-referenced-by-count":0,"title":["The impact of non-TB mycobacterial co-isolation in patients with pulmonary TB"],"prefix":"10.5588","volume":"3","author":[{"given":"S.","family":"Samari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.K.","family":"Brode","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.K.","family":"Mah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.S.","family":"Brar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.F.","family":"Sabur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"2026031809111018000_3.3.163.1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00804-2021"},{"issue":"S1","key":"2026031809111018000_3.3.163.2","first-page":"248","article-title":"Appendix B: de-isolation review and recommendations","volume":"6","author":"Cooper","year":"2022","journal-title":"Can J Respir Crit Care Sleep Med"},{"key":"2026031809111018000_3.3.163.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200511-1834OC"},{"key":"2026031809111018000_3.3.163.4","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200604-571ST"},{"issue":"7","key":"2026031809111018000_3.3.163.5","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.3201\/eid2907.230216","article-title":"Pulmonary nontuberculous mycobacteria, Ontario, Canada, 2020","volume":"29","author":"Marras","year":"2023","journal-title":"Emerg Infect Dis"},{"key":"2026031809111018000_3.3.163.6","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.12.0684"},{"key":"2026031809111018000_3.3.163.7","doi-asserted-by":"crossref","unstructured":"Sarro YD , Simultaneous diagnosis of tuberculous and non-tuberculous mycobacterial diseases: time for a better patient management. 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