{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T18:14:44Z","timestamp":1778523284087,"version":"3.51.4"},"reference-count":35,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJTLD Open"],"accepted":{"date-parts":[[2026,2,18]]},"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>The TB-PRACTECAL clinical trial assessed 24-week, all-oral bedaquiline, pretomanid, and linezolid (BPaL)-based regimens for rifampicin-resistant TB against standard of care (SoC). The PRACTECAL-PRO sub-study evaluated changes in quality of life (QoL), among patients receiving investigational regimens versus SoC, and assessed patient experiences of the new treatments.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We recruited participants from Belarus, Uzbekistan, and South Africa. Changes in QoL from baseline to 48 weeks were evaluated using the Short Form-12 (SF-12) and the St George\u2019s Respiratory Questionnaire (SGRQ). Longitudinal analysis was conducted for all six domains of SF-12 and SGRQ. In-depth interviews provided narratives about patients\u2019 experiences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>137 patients participated in PRACTICAL-PRO. All trial arms showed improved SF-12 and SGRQ scores over 48 weeks. Proportional reduction in scores for SGRQ per month was higher in investigational than SoC groups\u2019 Total score (13% vs. 4%), Impact (12% vs. 2%), Activity (14% vs. 7%), and Symptom (15% vs. 4%) domains, indicating quicker QoL improvement. Narratives indicated early treatment satisfaction and social acceptance, with wellbeing relying on family support, clinical contact, and counselling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Patients receiving short, all-oral BPaL-based regimens show improvements across all measured QoL domains, a positive impact on personal relationships, and a return to productive life. TB trials should routinely include patient-reported outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5588\/ijtldopen.25.0823","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:52:46Z","timestamp":1778521966000},"page":"319-326","source":"Crossref","is-referenced-by-count":0,"title":["Quality of life outcomes and patient-reported experiences in a randomised controlled trial for rifampicin-resistant TB (PRACTECAL-PRO): a mixed-methods study"],"prefix":"10.5588","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8453-0196","authenticated-orcid":true,"given":"K.","family":"Lowton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-6650","authenticated-orcid":true,"given":"B.","family":"Stringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5371-2314","authenticated-orcid":true,"given":"M.","family":"Cusinato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6524-3754","authenticated-orcid":true,"given":"K.","family":"Fielding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0059-9183","authenticated-orcid":true,"given":"I.","family":"Liverko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0165-6728","authenticated-orcid":true,"given":"R.","family":"Moodliar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7564-2679","authenticated-orcid":true,"given":"T.Z.","family":"Nikolaevna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1655-4000","authenticated-orcid":true,"given":"V.","family":"Solodovnikova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kazounis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9915-5878","authenticated-orcid":true,"given":"B.-T.","family":"Nyang\u2019wa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"2026051110524175000_3.5.319.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00322-0"},{"issue":"3","key":"2026051110524175000_3.5.319.2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2471\/BLT.17.198614","article-title":"Integrating tuberculosis and antimicrobial resistance control programmes","volume":"96","author":"Hasan","year":"2018","journal-title":"Bull World Health Organ"},{"key":"2026051110524175000_3.5.319.3","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-021-12056-1"},{"key":"2026051110524175000_3.5.319.4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147397"},{"key":"2026051110524175000_3.5.319.5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-7-211"},{"issue":"3","key":"2026051110524175000_3.5.319.6","doi-asserted-by":"crossref","first-page":"e0150849","DOI":"10.1371\/journal.pone.0150849","article-title":"\u201cWhen treatment is more challenging than the disease\u201d: a qualitative study of MDR-TB patient retention","volume":"11","author":"Shringarpure","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"2026051110524175000_3.5.319.7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3390\/healthcare8010026","article-title":"Role of empathy in health and social care","volume":"8","author":"Moudatsou","year":"2020","journal-title":"Healthcare"},{"key":"2026051110524175000_3.5.319.8","doi-asserted-by":"crossref","first-page":"100121","DOI":"10.1016\/j.jctube.2019.100121","article-title":"Quality of life with tuberculosis","volume":"17","author":"Aggarwal","year":"2019","journal-title":"J Clin Tuberc Other Mycobact Dis"},{"key":"2026051110524175000_3.5.319.9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijid.2014.12.045","article-title":"Health status and QoL in tuberculosis","volume":"32","author":"Brown","year":"2015","journal-title":"Int J Infect Dis"},{"key":"2026051110524175000_3.5.319.10","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-7-14"},{"key":"2026051110524175000_3.5.319.11","unstructured":"World Health Organization . 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