{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:30:40Z","timestamp":1786649440430,"version":"build-2736575974"},"reference-count":35,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IJTLD Open"],"accepted":{"date-parts":[[2026,5,4]]},"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>TB preventive treatment (TPT) is central to reducing TB incidence among high-risk populations. This paper presents learnings from a large-scale TPT implementation under a Global Fund-supported project in India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The project targeted household contacts (HHCs) of people with pulmonary TB (PTB) across 208 districts in 23 states. Data on symptom-based screening, TPT initiation, adherence, and completion were analysed to inform scale-up strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Of 3,097,831 HHCs identified from 851,974 people with PTB, 91% were symptom-screened, and among those screened 28% underwent chest X-ray and 54% initiated TPT, with an 84% completion rate. Integration with active case finding, portable digital chest X-rays, and short-course regimens (3HP) improved coverage. Decentralised service delivery through Health and Wellness Centres and engagement of community health workers enhanced treatment access and follow-up. Teleconsultations, digital tracking, and incentive mechanisms supported adherence. Challenges included early discontinuation due to adverse drug reactions, regional diagnostic disparities, and limited private sector engagement.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>Large-scale TPT delivery is feasible in high-burden settings when integrated with routine health system platforms and community-based approaches. Key operational insights included chest X-ray screening, and scale-up of shorter regimens, supporting India\u2019s TB elimination goals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5588\/ijtldopen.26.0168","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:54:08Z","timestamp":1786647248000},"page":"511-519","source":"Crossref","is-referenced-by-count":0,"title":["Lessons learned from implementing a large-scale contact investigation and TB preventive treatment project in India"],"prefix":"10.5588","volume":"3","author":[{"given":"B.","family":"Kalottee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Nuken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.S.","family":"Chadha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mannan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Solanki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Taralekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yassin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Restrepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Mattoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Dhawan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rajan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3554","published-online":{"date-parts":[[2026,8,1]]},"reference":[{"key":"2026081311535888000_3.8.511.1","unstructured":"World Health Organization . 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