{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:13:37Z","timestamp":1768450417408,"version":"3.49.0"},"reference-count":0,"publisher":"International Union Against Tuberculosis and Lung Disease","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["public health action"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec id=\"st1\">\n                    <jats:title>Setting:<\/jats:title>\n                    <jats:p>Thirteen methadone maintenance treatment (MMT) clinics across Yunnan, the province with the highest human immunodeficiency virus (HIV) burden in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st2\">\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>To determine, among HIV-negative participants on MMT, the proportion lost to follow-up (defined as those who missed the 6-monthly follow-up examination), factors associated with loss to follow-up (LFU), HIV seroconversion rate and factors associated with seroconversion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st3\">\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>\n                      Prospective cohort study from October 2008 to April 2011. All participants were administered a pretested structured questionnaire to capture associated factors and offered HIV testing every 6 months. \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test and log-binomial regression were used for data analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st4\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Of 1146 participants, 541 (47%) were lost to follow-up in 2.5 years. Factors associated with higher LFU proportion include &lt;6 months of previous MMT, inconvenient location of the MMT clinic and average methadone dose \u226460 mg\/day, with adjusted relative risks (RRs) of respectively 1.4 (95%CI 1.2\u20131.5), 1.2 (95VCI 1.0\u20131.4) and 1.1 (95%CI 1.0\u20131.3). The overall HIV seroconversion rate was 6.6 (95%CI 3.7\u201311.0) per 1000 person-years. Not living with a partner contributed to higher HIV rates, with an adjusted RR of 3.6 (95%CI 1.0\u201312.8).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"st5\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The retention rate of MMT participants in Yunnan was not satisfactory. Decentralising service delivery in the community and making directly observed treatment more convenient has the potential to improve retention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.5588\/pha.13.0101","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:51:37Z","timestamp":1395708697000},"page":"28-34","source":"Crossref","is-referenced-by-count":6,"title":["Retention and HIV seroconversion among drug users on methadone maintenance treatment in Yunnan, China"],"prefix":"10.5588","volume":"4","author":[{"given":"Y-P.","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Duo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M. V.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Achanta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H-M.","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Satyanarayana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ananthakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-Y.","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3554","published-online":{"date-parts":[[2014,3,1]]},"container-title":["Public Health Action"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.5588\/pha.13.0101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T17:12:14Z","timestamp":1768410734000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.theunion.org\/lookup\/doi\/10.5588\/pha.13.0101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,3,1]]},"published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.5588\/pha.13.0101"],"URL":"https:\/\/doi.org\/10.5588\/pha.13.0101","relation":{},"ISSN":["2220-8372"],"issn-type":[{"value":"2220-8372","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}