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Experimental approach: We reviewed full-text studies from the past decade across PubMed, Web of Science and Google Scholar, applying explicit inclusion\/ex\u00adclusion criteria; emphasis was placed on Genome wide association studies and Next generation sequencing findings, immune and androgen-axis biology, environmental modifiers, and therapeutic evidence (conven\u00adtional, targeted, and regenerative), alongside artificial Intelligence-enabled diagnostics. Key results: Andro\u00adgenetic alopecia risk converges on androgen-receptor signalling and related loci, with perifollicular inflam\u00admation and oxidative stress as modifiers; finasteride remains a cornerstone therapy. Alopecia areata reflects polygenic immune dysregulation (e.g. Human leukocyte antigen\/cytokine axes) with Janus Kinase-pathway inhibition yielding robust regrowth; across phenotypes, wingless-related integration sit\/\u03b2-catenin and stem-cell programs are central targets. Regenerative options (Protein Rich Plasma, stem-cell\/exosome appro\u00adaches) and artificial Intelligence-assisted stratification are emerging adjuncts. Conclusion: A pathway-guided, genotype and phenotype-informed strategy, targeting the androgen axis for androgenetic alopecia, immune circuits for alopecia areata, and adding regenerative or microenvironmental therapies where indicated-promises earlier diagnosis and more durable, individualized outcomes, especially as genome-wide association study\/next-generation sequencing and artificial Intelligence tools are integrated into care.<\/jats:p>","DOI":"10.5599\/admet.3030","type":"journal-article","created":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T11:56:03Z","timestamp":1765886163000},"page":"3030","source":"Crossref","is-referenced-by-count":1,"title":["Precision therapeutics in non-scarring alopecia: a systemic genomic and pathway-based framework for targeted interventions"],"prefix":"10.5599","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2443-878X","authenticated-orcid":false,"given":"Rinky","family":"Kapoor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1045-9758","authenticated-orcid":false,"given":"Depti","family":"Bellani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2725-7578","authenticated-orcid":false,"given":"Raji","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0350-3839","authenticated-orcid":false,"given":"Debalina","family":"Bose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3959-0223","authenticated-orcid":false,"given":"Madhuri","family":"Pola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0427-6866","authenticated-orcid":false,"given":"Prashant Anilkumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3797-7133","authenticated-orcid":false,"given":"Mamata","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8026-4629","authenticated-orcid":false,"given":"Debraj","family":"Shome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3564","published-online":{"date-parts":[[2025,12,16]]},"reference":[{"key":"155409","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S376096"},{"key":"155410","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030612"},{"key":"155411","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218390"},{"key":"155412","doi-asserted-by":"publisher","DOI":"10.21608\/bjas.2024.261687.1307"},{"key":"155413","doi-asserted-by":"publisher","DOI":"10.4103\/amhs.amhs_228_20"},{"key":"155414","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.1054898"},{"key":"155415","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25115652"},{"key":"155416","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116666"},{"key":"155417","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2020.3384"},{"key":"155418","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkac022"},{"key":"155419","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.82991"},{"key":"155420","doi-asserted-by":"publisher","DOI":"10.3390\/genes14071362"},{"key":"155421","doi-asserted-by":"publisher","DOI":"10.1159\/000530432"},{"key":"155422","unstructured":"[14] N. 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