{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:36:29Z","timestamp":1792092989896,"version":"4.4.0"},"reference-count":58,"publisher":"International Association of Physical Chemists (IAPC)","license":[{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ADMET DMPK"],"abstract":"<jats:p>Background and purpose: Asthma, a chronic airway inflammatory disorder driven by multifaceted genetic, cellular and molecular interactions, remains inadequately managed by single-target therapies due to incomplete disease control and adverse effects; this review aimed to explore network pharmacology's role in elucidating multi-target mechanisms of phytotherapeutic agents for asthma, with a focus on integrating ADMET\/DMPK profiling to predict clinical translatability and safety. Experimental approach: We employed network pharmacology methodologies including target prediction (e.g. via PharmMapper, PubChem), protein-protein interaction network construction (STRING, Cytoscape), pathway enrichment analysis (KEGG, Reactome), molecular docking (AutoDock) and ADMET\/DMPK modelling (SwissADME, pkCSM) to dissect multi-component herbal formulations, complemented by literature-mined experimental validations. Key results: Analyses identified key asthma-related targets (e.g. IL-17, TNF) and pathways (JAK-STAT, PI3K-AKT), revealing quercetin and kaempferol's multi-target efficacy in reducing airway inflammation and immune dysregulation; favourable ADMET profiles (high oral bioavailability, low toxicity) and DMPK parameters (metabolic stability via CYP inhibition) supported their therapeutic potential in herbal combinations. Conclusion: Network pharmacology, enhanced by ADMET\/DMPK integration, advances a holistic under\u00adstanding of herbal asthma treatments, promoting safe, multi-target drug development. Limitations include data gaps in multi-omics validation and herbal standardization, with future directions leveraging AI-driven predictions for personalized pharmacotherapy.<\/jats:p>","DOI":"10.5599\/admet.3281","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:01:52Z","timestamp":1778176912000},"source":"Crossref","is-referenced-by-count":1,"title":["Leveraging network pharmacology in the treatment of asthma"],"prefix":"10.5599","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5143-1886","authenticated-orcid":false,"given":"Sarthi","family":"Ahuja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5152-0080","authenticated-orcid":false,"given":"Richard Cherehani","family":"Kashindye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-6618","authenticated-orcid":false,"given":"Divya","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1095-0565","authenticated-orcid":false,"given":"Priyanka","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8932-5076","authenticated-orcid":false,"given":"Rakesh","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3564","published-online":{"date-parts":[[2026,5,7]]},"reference":[{"key":"178067","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1612688"},{"key":"178068","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2025-003144"},{"key":"178069","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00528-2021"},{"key":"178070","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01742-w"},{"key":"178071","doi-asserted-by":"publisher","DOI":"10.1177\/2156587215584862"},{"key":"178072","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-1437"},{"key":"178073","doi-asserted-by":"publisher","DOI":"10.3390\/life13020411"},{"key":"178074","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9732626"},{"key":"178075","doi-asserted-by":"publisher","DOI":"10.3831\/KPI.2023.26.2.124"},{"key":"178076","doi-asserted-by":"publisher","DOI":"10.1007\/s13596-011-0019-1"},{"key":"178077","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujim.2021.101358"},{"key":"178078","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-025-01142-w"},{"key":"178079","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.644561"},{"key":"178080","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/621423"},{"key":"178081","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.118"},{"key":"178082","doi-asserted-by":"publisher","DOI":"10.1007\/s12064-024-00419-2"},{"key":"178083","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-023-00853-2"},{"key":"178084","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801814-9.00005-2"},{"key":"178085","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/7671247"},{"key":"178086","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4749613"},{"key":"178087","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1361379"},{"key":"178088","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"178089","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"178090","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03625-3"},{"key":"178091","doi-asserted-by":"publisher","DOI":"10.3390\/ph15050572"},{"key":"178092","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-6-13"},{"key":"178093","doi-asserted-by":"crossref","unstructured":"[27] B. 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