{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:41:54Z","timestamp":1786293714940,"version":"build-2736575974"},"reference-count":75,"publisher":"International Association of Physical Chemists (IAPC)","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100018678","name":"APJ Abdul Kalam Technological University","doi-asserted-by":"publisher","award":["U.O.No. 539\/2021\/KTU"],"award-info":[{"award-number":["U.O.No. 539\/2021\/KTU"]}],"id":[{"id":"10.13039\/100018678","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ADMET DMPK"],"abstract":"<jats:p>Background and purpose: Erlotinib (ERL), a first-generation epidermal growth factor receptor tyrosine kinase inhibitor drug that is used in non-small cell lung cancer treatment, requires precise therapeutic drug monitoring owing to its narrow therapeutic window and significant inter-patient pharmacokinetic variability; existing chromatographic methods, while robust, are resource-intensive and incompatible with point-of-care settings, necessitating the development of simpler, cost-effective electroanalytical alternatives. Experimental approach: A titanium dioxide nanoparticle-modified screen-printed electrode (TiO\u2082NP@SPE) was fabricated via a facile single-step modification and comprehensively characterized by scanning electron microscopy - energy dispersive X-ray Analysis, Fourier transform infrared spectroscopy, X-ray diffraction and electrochemical impedance spectroscopy; electrochemical performance was evaluated by cyclic voltammetry and differential pulse voltammetry, and analytical validation was performed in human serum using the standard addition method. Key results: The TiO\u2082NP@SPE demonstrated markedly enhanced electron transfer kinetics over the bare SPE, yielding a well-defined linear response with a competitive limit of detection, high sensitivity, and intra- and inter-day serum recoveries within acceptable precision limits, alongside excellent selectivity against physiologically relevant interferents and structurally related anticancer agents. Conclusion: This work developed a disposable screen-printed electrode sufficient to achieve sensitive, selective, and accurate quantification of ERL in human serum using TiO\u2082NP@SPE as a promising, clinically translatable platform for point-of-care therapeutic drug monitoring in oncology; future efforts should address the elevated detection limit relative to the bare electrode and extend validation to real patient plasma samples to fully confirm clinical applicability.<\/jats:p>","DOI":"10.5599\/admet.3437","type":"journal-article","created":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T16:04:02Z","timestamp":1786291442000},"source":"Crossref","is-referenced-by-count":0,"title":["Titanium dioxide nanoparticle-modified screen-printed electrode for erlotinib determination"],"prefix":"10.5599","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1695-7344","authenticated-orcid":false,"given":"Pooja Das","family":"Manjulabhai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0528-5505","authenticated-orcid":false,"given":"Sruthi","family":"Mundangadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9164-209X","authenticated-orcid":false,"given":"Maria","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7461-8847","authenticated-orcid":false,"given":"Srinivedha","family":"Lal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1258-3577","authenticated-orcid":false,"given":"Namitha","family":"Ramalal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9476-1655","authenticated-orcid":false,"given":"Mariya","family":"Anto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9313-0770","authenticated-orcid":false,"given":"Dhanya","family":"Gangadharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3564","published-online":{"date-parts":[[2026,8,9]]},"reference":[{"key":"194354","doi-asserted-by":"crossref","unstructured":"[1] Y. 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