{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:54:19Z","timestamp":1780635259478,"version":"3.54.1"},"reference-count":0,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Respiratory Medicine"],"abstract":"<jats:p>Introduction: While exercise has been shown to improve respiratory symptoms, exercise tolerance, and bone mineral density in many populations, no supervised exercise training interventions have been undertaken in patients with lymphangioleiomyo-matosis (LAM). Material and methods: One patient with TSC-LAM (tuberous sclerosis complex lymphangioleiomyomatosis) participated in two weekly sessions (50\u201360 min) of supervised aerobic exercise at 80\u201385% heart rate max for one year. Treadmill ergometry (VO2peak), spirometry (FEV1, FVC, FEV1\/FVC, peak flow), and bone mineral density testing were performed prior to every 3 months. Results: After one year of supervised aerobic exercise training we saw dramatic increases in the patient\u2019s VO2max (20%), FEV1 (9.5%), FEV1\/FVC (9.1%) and peak flow (47%).  Conclusions: The results from this study indicate that supervised exercise training can improve exercise tolerance and pulmonary function in a patient with lymphangioleiomyomatosis. Further research is needed, including longitudinal studies with larger sample sizes, to determine long-term effects and consistency of these findings. Aerobic exercise may offer a viable alternative or com-pliment to pharmacological interventions in the treatment of lymphangioleiomyomatosis. We show that high-intensity exercise training can markedly and safely improve pulmonary function in a patient with TSC-LAM. While we did not record quality of life or mood states, our patient did report improved self-confidence as well as enhanced mood.<\/jats:p>","DOI":"10.5603\/arm.a2020.0129","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T06:40:55Z","timestamp":1598942455000},"page":"356-359","source":"Crossref","is-referenced-by-count":4,"title":["High-Intensity Exercise Improves Pulmonary Function and Exercise Tolerance in a Patient with TSC-LAM"],"prefix":"10.3390","volume":"88","author":[{"given":"Thomas","family":"Lowder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,27]]},"container-title":["Advances in Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2543-6031\/88\/4\/356\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T09:33:49Z","timestamp":1657272829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2543-6031\/88\/4\/356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,8]]}},"alternative-id":["ARM.a2020.0129"],"URL":"https:\/\/doi.org\/10.5603\/arm.a2020.0129","relation":{},"ISSN":["2543-6031"],"issn-type":[{"value":"2543-6031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,27]]}}}