{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T14:01:58Z","timestamp":1758808918545},"reference-count":0,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Respiratory Medicine"],"abstract":"<jats:p>Introduction: We aimed to investigate community-acquired pneumonia (CAP) requiring hospitalisation, empirically treated with \u03b2-lactam monotherapy, with 30-day mortality and risk factors predicting its complicated course. Material and methods: A prospective observational study was conducted at the Pulmonology and Allergology Department in a tertiary care university hospital. 253 consecutive patients diagnosed with CAP requiring hospitalisation were enrolled. Hospital admission was based on PSI or CRB-65 scores, severe comorbidities, signs of intoxication, aspiration risk, social risk consider-ations, ineffective prior antibiotic treatment. Results: Fourty seven percent of the subjects had complications on admission, 13% developed new CAP complications during inpatient treatment. Overall, 53% of individuals had a complicated CAP course. 30-day mortality rate was 5.9%. The factors predicting a complicated CAP course were as follows: neuromuscular disease, multilobar opacities on chest X-ray (or computed tomography), and clinically unstable condition as evaluated using Halm\u2019s criteria. Conclusions: The mortality rate in CAP patients treated with b-lactam monotherapy is low. Neuromuscular disease, multilobar opacities, and clinically unstable condition as evaluated using Halm\u2019s criteria predict a complicated CAP course.<\/jats:p>","DOI":"10.5603\/arm.a2021.0070","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T06:35:03Z","timestamp":1631082903000},"page":"359-368","source":"Crossref","is-referenced-by-count":1,"title":["Risk Factors for Complicated Community-Acquired Pneumonia Course in Patients Treated with \u03b2-Lactam Monotherapy"],"prefix":"10.3390","volume":"89","author":[{"given":"Giedr\u0117","family":"Cincilevi\u010di\u016bt\u0117","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vaida","family":"Averjanovait\u0117","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R\u016bta","family":"Mere\u0161kevi\u010dien\u0117","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel\u0117","family":"Pliatkien\u0117","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolandas","family":"Zablockis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edvardas","family":"Danila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,16]]},"container-title":["Advances in Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2543-6031\/89\/4\/359\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T09:36:27Z","timestamp":1657272987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2543-6031\/89\/4\/359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":0,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["ARM.a2021.0070"],"URL":"https:\/\/doi.org\/10.5603\/arm.a2021.0070","relation":{},"ISSN":["2543-6031"],"issn-type":[{"value":"2543-6031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]}}}