{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T05:02:05Z","timestamp":1664254925918},"reference-count":0,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2013,12,20]],"date-time":"2013-12-20T00:00:00Z","timestamp":1387497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Respiratory Medicine"],"abstract":"<jats:p>Przez wiele lat podstawowym testem identyfikuj\u0105cym latentne (utajone) zaka\u017cenie pr\u0105tkami gru\u017alicy (LTBI) by\u0142a pr\u00f3ba tuberkulinowa, posiadaj\u0105ca pewne ograniczenia, kt\u00f3re wynikaj\u0105 przede wszystkim z niskiej czu\u0142o\u015bci i specyficzno\u015bci. Obecnie stosuje si\u0119 testy IGRA z krwi obwodowej, umo\u017cliwiaj\u0105ce szybk\u0105 diagnostyk\u0119 LTBI poprzez pomiar interferonu gamma (IFN-\u03b3) wydzielanego przez limfocyty T pobudzone swoistymi dla Mycobacterium tuberculosis antygenami. Wykrywanie LTBI ma istotne znaczenie w kontroli os\u00f3b potencjalnie zagro\u017conych zachorowaniem na gru\u017alic\u0119, na przyk\u0142ad przebywaj\u0105cych w bliskim kontakcie z chorymi pr\u0105tkuj\u0105cymi oraz dla pacjent\u00f3w kwalifikowanych do leczenia lekami biologicznymi. W pracy przedstawiono 3 wybrane sytuacje kliniczne, w kt\u00f3rych zastosowano testy IGRA. W dw\u00f3ch przypadkach rozpoznano ostatecznie utajone zaka\u017cenie pr\u0105tkami gru\u017alicy, a w jednym aktywn\u0105 gru\u017alic\u0119.<\/jats:p>","DOI":"10.5603\/piap.2014.0007","type":"journal-article","created":{"date-parts":[[2014,1,6]],"date-time":"2014-01-06T11:09:03Z","timestamp":1389006543000},"page":"39-45","source":"Crossref","is-referenced-by-count":1,"title":["Testy IGRA w Diagnostyce Zaka\u017cenia Pr\u0105tkami Gru\u017alicy w Wybranych Sytuacjach Klinicznych"],"prefix":"10.3390","volume":"82","author":[{"given":"Dagmara","family":"Borkowska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"El\u017cbieta","family":"Radzikowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolanta","family":"Za\u0142\u0119ska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Zio\u0142kowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Klatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zofia","family":"Zwolska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewa","family":"Augustynowicz-Kope\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazimierz","family":"Roszkowski-\u015ali\u017c","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2013,12,20]]},"container-title":["Advances in Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2543-6031\/82\/1\/39\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T09:00:32Z","timestamp":1664182832000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2543-6031\/82\/1\/39"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,20]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2014,1]]}},"alternative-id":["PiAP.2014.0007"],"URL":"https:\/\/doi.org\/10.5603\/piap.2014.0007","relation":{},"ISSN":["2543-6031"],"issn-type":[{"value":"2543-6031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,20]]}}}