{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T05:02:10Z","timestamp":1664254930395},"reference-count":0,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2014,4,30]],"date-time":"2014-04-30T00:00:00Z","timestamp":1398816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Respiratory Medicine"],"abstract":"<jats:p>Choroba zarostowa \u017cy\u0142 p\u0142ucnych (PVOD) jest bardzo rzadk\u0105 przyczyn\u0105 nadci\u015bnienia p\u0142ucnego o ci\u0119\u017ckim przebiegu i z\u0142ym rokowaniu. W pracy zaprezentowano przypadek 24-letniego pacjenta, u kt\u00f3rego pierwszymi symptomami choroby by\u0142y narastaj\u0105ca duszno\u015b\u0107 i pogorszenie tolerancji wysi\u0142ku. Pacjent, do czasu postawienia w\u0142a\u015bciwej diagnozy na podstawie wyniku badania histopatologicznego wycinka z biopsji p\u0142uca, by\u0142 leczony antagonistami wapnia i glikokortykosteroidami na podstawie wst\u0119pnej diagnozy nadci\u015bnienia p\u0142ucnego i choroby \u015br\u00f3dmi\u0105\u017cszowej p\u0142uc. Przypadek ten ukazuje, \u017ce PVOD to jednostka trudna diagnostycznie i oporna na wszelkie leczenie zachowawcze, co jest szczeg\u00f3lnie niekorzystnym czynnikiem rokowniczym dla pacjent\u00f3w. Wobec braku skutecznego leczenia farmakologicznego i wysokiej \u015bmiertelno\u015bci pacjent\u00f3w choruj\u0105cych na PVOD, zrozumienie patogenezy choroby zarostowej \u017cy\u0142 p\u0142ucnych, a tak\u017ce r\u00f3\u017cnicowanie jej z t\u0119tniczym nadci\u015bnieniem p\u0142ucnym oraz poszukiwanie nowych metod terapeutycznych pozostaj\u0105 wa\u017cnymi wyzwaniami dla wsp\u00f3\u0142czesnej medycyny.<\/jats:p>","DOI":"10.5603\/piap.2014.0032","type":"journal-article","created":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T10:29:29Z","timestamp":1474540169000},"page":"271-275","source":"Crossref","is-referenced-by-count":0,"title":["24-letni pacjent z chorob\u0105 zarostow\u0105 \u017cy\u0142 p\u0142ucnych\u2014Opis przypadku"],"prefix":"10.3390","volume":"82","author":[{"given":"Edyta","family":"\u0106wiek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelina","family":"Przem\u0119cka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerzy","family":"Marczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Ku\u015b","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Langfort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawe\u0142","family":"G\u00f3rski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,4,30]]},"container-title":["Advances in Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2543-6031\/82\/3\/271\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T09:01:01Z","timestamp":1664182861000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2543-6031\/82\/3\/271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,30]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,4]]}},"alternative-id":["PiAP.2014.0032"],"URL":"https:\/\/doi.org\/10.5603\/piap.2014.0032","relation":{},"ISSN":["2543-6031"],"issn-type":[{"value":"2543-6031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,30]]}}}