{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T11:32:01Z","timestamp":1789990321910,"version":"4.0.1"},"reference-count":0,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2014,8,18]],"date-time":"2014-08-18T00:00:00Z","timestamp":1408320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Respiratory Medicine"],"abstract":"<jats:p>Pneumocystozowe zapalenie p\u0142uc (PCP) jest jedn\u0105 z wielu infekcyjnych chor\u00f3b uk\u0142adu oddechowego u zaka\u017conych HIV wywo\u0142ywan\u0105 przez patogen Pneumocystis jiroveci, zaliczany do grzyb\u00f3w. Pneumocystoza jest od ponad 30 lat najcz\u0119stsz\u0105 chorob\u0105 wska\u017anikow\u0105 zespo\u0142u nabytego niedoboru odporno\u015bci (AIDS). Najwa\u017cniejszym czynnikiem ryzyka rozwoju PCP jest obni\u017cenie liczby limfocyt\u00f3w T CD4+ poni\u017cej 200 kom\u00f3rek\/mcL. Objawy kliniczne choroby to: przewlek\u0142y kaszel, duszno\u015b\u0107 i os\u0142abienie. W badaniu gazometrycznym krwi t\u0119tniczej lub arterializowanej krwi kapilarnej cz\u0119sto stwierdza si\u0119 hipoksemi\u0119, a w tomografii komputerowej o wysokiej rozdzielczo\u015bci \u2014 obraz matowej szyby. Leczeniem z wyboru jest parenteralne podawanie trimetoprimu z sulfametoksazolem, U chorych w \u015brednim i ci\u0119\u017ckim stanie zaleca si\u0119 systemowe podawanie glikokortykosteroid\u00f3w. Wsp\u00f3\u0142istnienie zaka\u017cenia wirusem cytomegalii (CMV) pogarsza rokowanie chorych. Narz\u0105dowego zaj\u0119cia w przebiegu zaka\u017cenia CMV nale\u017cy poszukiwa\u0107 u chorych z liczb\u0105 kom\u00f3rek T CD4+ poni\u017cej 50\/mcL. Kwesti\u0105 sporn\u0105 pozostaje leczenie zaka\u017cenia CMV u chorych z rozpoznanym PCP. Uwa\u017ca si\u0119, \u017ce w wi\u0119kszo\u015bci przypadk\u00f3w zaka\u017cenie CMV pozostaje bezobjawowe. Glikokortykosteroidy podawane w przypadkach PCP o ci\u0119\u017cszym przebiegu mog\u0105 pogarsza\u0107 rokowanie i promowa\u0107 rozw\u00f3j objawowego cytomegalowirusowego zapalenia p\u0142uc. W pracy przedstawiono dwa przypadki PCP, kt\u00f3re by\u0142y pierwszym objawem zaka\u017cenia HIV. W obu udowodniono r\u00f3wnie\u017c zaka\u017cenie CMV.<\/jats:p>","DOI":"10.5603\/piap.2014.0060","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T14:07:17Z","timestamp":1409580437000},"page":"458-466","source":"Crossref","is-referenced-by-count":4,"title":["Pneumocystozowe Zapalenie P\u0142uc u Zaka\u017conych HIV Przy Wsp\u00f3\u0142istniej\u0105cym Zaka\u017ceniu Cytomegalowirusem. Opis Dw\u00f3ch Przypadk\u00f3w i Przegl\u0105d Literatury"],"prefix":"10.3390","volume":"82","author":[{"given":"Mateusz","family":"Polaczek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Zych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Oniszh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Szopi\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek","family":"Grudny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazimierz","family":"Roszkowski-\u015ali\u017c","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2014,8,18]]},"container-title":["Advances in Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2543-6031\/82\/5\/458\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T09:01:29Z","timestamp":1664182889000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2543-6031\/82\/5\/458"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,18]]},"references-count":0,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,8]]}},"alternative-id":["PiAP.2014.0060"],"URL":"https:\/\/doi.org\/10.5603\/piap.2014.0060","relation":{},"ISSN":["2543-6031"],"issn-type":[{"value":"2543-6031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,18]]}}}