{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T05:01:39Z","timestamp":1664254899309},"reference-count":0,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2014,10,22]],"date-time":"2014-10-22T00:00:00Z","timestamp":1413936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Advances in Respiratory Medicine"],"abstract":"<jats:p>Leflunomid (LEF), pochodna izoksazolowa, nale\u017cy do lek\u00f3w przeciwreumatycznych modyfikuj\u0105cych przebieg choroby (DMARDs), kt\u00f3re stanowi\u0105 podstaw\u0119 leczenia reumatoidalnego zapalenia staw\u00f3w (RZS). J est lekiem skutecznym i bezpiecznym u chorych na RZS w sytuacji, gdy standardowe leczenie nie spowodowa\u0142o znacz\u0105cej poprawy lub by\u0142o \u017ale tolerowane, ale mo\u017ce wywo\u0142ywa\u0107 \u015br\u00f3dmi\u0105\u017cszow\u0105 chorob\u0119 p\u0142uc. Czynnikami ryzyka wyst\u0105pienia \u015br\u00f3dmi\u0105\u017cszowej choroby p\u0142uc wywo\u0142anej LEF s\u0105: stwierdzane wcze\u015bniej zmiany \u015br\u00f3dmi\u0105\u017cszowe w p\u0142ucach, palenie papieros\u00f3w, niska masa cia\u0142a i stosowanie dawki nasycaj\u0105cej. W pracy przedstawiono przypadek 59-letniego chorego na RZS, z nikotynizmem w wywiadzie, leczonego w przesz\u0142o\u015bci metotreksatem (MTX), u kt\u00f3rego wyst\u0105pi\u0142y duszno\u015b\u0107, kaszel i gor\u0105czka po oko\u0142o 2 miesi\u0105cach leczenia LEF. Z astosowano metyloprednizolon w pulsach, nast\u0119pnie prednizon i cyklofosfamid. Po okresie przej\u015bciowej poprawy dosz\u0142o do narastania niewydolno\u015bci oddechowej i zgonu.<\/jats:p>","DOI":"10.5603\/piap.2014.0075","type":"journal-article","created":{"date-parts":[[2014,10,23]],"date-time":"2014-10-23T06:29:11Z","timestamp":1414045751000},"page":"568-575","source":"Crossref","is-referenced-by-count":1,"title":["Ostre \u015br\u00f3dmi\u0105\u017cszowe Zapalenie P\u0142uc u Chorego na Reumatoidalne Zapalenie Staw\u00f3w Leczonego Leflunomidem"],"prefix":"10.3390","volume":"82","author":[{"given":"Izabela","family":"Siemion-Szcze\u015bniak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Bartoszuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Bartosiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilia","family":"Jakubowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Weso\u0142owski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Ku\u015b","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2014,10,22]]},"container-title":["Advances in Respiratory Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2543-6031\/82\/6\/568\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T09:01:42Z","timestamp":1664182902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2543-6031\/82\/6\/568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,22]]},"references-count":0,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2014,10]]}},"alternative-id":["PiAP.2014.0075"],"URL":"https:\/\/doi.org\/10.5603\/piap.2014.0075","relation":{},"ISSN":["2543-6031"],"issn-type":[{"value":"2543-6031","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,22]]}}}