{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:29:20Z","timestamp":1791725360316,"version":"4.3.4"},"reference-count":29,"publisher":"Walter de Gruyter GmbH","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Hig Med Dosw"],"published-print":{"date-parts":[[2017,1,4]]},"abstract":"<jats:p>&lt;b&gt;Introduction: &lt;\/b&gt;It is known that in the pathogenesis of tick-borne encephalitis (TBE) various molecules play a significant role. The most prominent factors include IL-10, IL-28B, CD-209 and CCR5. It is reasonable to search for genetic predispositions to the development of various clinical forms of TBE related to the genetic variation of IL-10, IL-28B, CD-209 and CCR5. In this study we aimed to search for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (\u0394 32) with the human predisposition to development of various clinical presentations of TBE. We tried to assess the relation between the presence of particular alleles and genotypes with laboratory and clinical parameters. &lt;b&gt;Material\/Methods &lt;\/b&gt;59 patients with TBE and 57 people, bitten by a tick who never developed TBE (Polish cohort), were included in the study. To assess the distribution of single nucleotide polymorphisms, TaqMan SNP genotyping assays were used for IL10: rs1800872 and rs1800896, for CD 209 rs4804803 and rs2287886, rs12979860 for IL 28B SNPs according to the manufacturer\u2019s protocol using real-time PCR technology on the StepOne thermal cycler. &lt;b&gt;Results &lt;\/b&gt;Comparison between TBE patients and CG showed that in SNP rs2287886 CD 209 AG heterozygotes were more frequent in the TBE group, while homozygotes GG were more frequent in the CG group. &lt;b&gt;Conclusions &lt;\/b&gt; SNP rs2287886 CD 209 AG heterozygotes predispose humans to develop TBE. Single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and CCR5 D32 genes does not correlate with the severity of TBE.<\/jats:p>","DOI":"10.5604\/01.3001.0010.3856","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T09:19:26Z","timestamp":1505207966000},"page":"0-0","source":"Crossref","is-referenced-by-count":10,"title":["Analysis of the relationship between single nucleotide polymorphism of the CD209, IL-10, IL-28 and CCR5 D32 genes with the human predisposition to developing tick-borne encephalitis"],"prefix":"10.2478","volume":"71","author":[{"given":"Piotr","family":"Czupryna","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University in Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi\u0142osz","family":"Parczewski","sequence":"additional","affiliation":[{"name":"Department of Infectious, Tropical Diseases and Immune Deficiency, Pomeranian Medical University, Szczecin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sambor","family":"Grygorczuk","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University in Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u0142awomir","family":"Pancewicz","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University in Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Zajkowska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University in Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Dunaj","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University in Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Kondrusik","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University in Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Krawczuk","sequence":"additional","affiliation":[{"name":"Pediatric Observation Unit, University Hospital of Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Moniuszko-Malinowska","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases and Neuroinfections, Medical University in Bia\u0142ystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"374","reference":[{"key":"152357r1","doi-asserted-by":"crossref","unstructured":"Atrasheuskaya A.V., Fredeking T.M., Ignatyev G.M.: Changes inimmune parameters and their correction in human cases of tick--borne encephalitis. Clin. Exp. Immunol., 2003; 131: 148-154","DOI":"10.1046\/j.1365-2249.2003.02050.x"},{"key":"152357r2","doi-asserted-by":"crossref","unstructured":"Barkhash A.V., Perelygin A.A., Babenko V.N., Brinton M.A., VoevodaM.I.: Single nucleotide polymorphism in the promoter regionof the CD209 gene is associated with human predisposition to severeforms of tick- borne encephalitis. Antiviral Res., 2012; 93: 64-68","DOI":"10.1016\/j.antiviral.2011.10.017"},{"key":"152357r3","doi-asserted-by":"crossref","unstructured":"Czupryna P., Moniuszko A., Pancewicz S.A., Grygorczuk S., KondrusikM., Zajkowska J.: Tick-borne encephalitis in Poland in years1993-2008 - epidemiology and clinical presentation. A retrospectivestudy of 687 patients. Eur. J. Neurol., 2011; 18: 673-679","DOI":"10.1111\/j.1468-1331.2010.03278.x"},{"key":"152357r4","unstructured":"Ge D., Fellay J., Thompson A.J., Simon J.S., Shianna K.V., UrbanT.J., Heinzen E.L., Qiu P., Bertelsen A.H., Muir A.J., Sulkowski M.,McHutchison J.G., Goldstein D.B.: Genetic variation in IL28B predictshepatitis C treatment-induced viral clearance. Nature, 2009;461: 399-401 5 Glass W.G., McDermott D.H., Lim J.K., Lekhong S., Yu S.F., Frank W.A.,Pape J., Cheshier R.C., Murphy P.M.: CCR5 deficiency increases risk ofsymptomatic West Nile virus infection. J. Exp. Med., 2006; 203: 35-40"},{"key":"152357r5","doi-asserted-by":"crossref","unstructured":"(CCR5) gene is associated with tickborne encephalitis. J. Infect.Dis., 2008; 1975: 266-269","DOI":"10.1086\/524709"},{"key":"152357r6","doi-asserted-by":"crossref","unstructured":"Grebely J., Petoumenos K., Hellard M., Matthews G.V., SuppiahV., Applegate T., Yeung B., Marks P., Rawlinson W., Lloyd A.R., BoothD., Kaldor J.M., George J., Dore G.J., ATAHC Study Group: Potentialrole for interleukin-28B genotype in treatment decision-making inrecent hepatitis C virus infection. Hepatology, 2010; 52: 1216-1224","DOI":"10.1002\/hep.23850"},{"key":"152357r7","doi-asserted-by":"crossref","unstructured":"G\u00fcnther G., Haglund M., Lindquist L., Forsgren M., Andersson J.,Andersson B., Sk\u00f6ldenberg B.: Tick-borne encephalitis is associatedwith low levels of interleukin-10 in cerebrospinal fluid. Infect. Ecol.Epidemiol., 2011; 1: 6029","DOI":"10.3402\/iee.v1i0.6029"},{"key":"152357r8","unstructured":"Ignat\u2019ev G.M., Otrashevskaia E.V., Vorob\u2019eva M.C.: Cytokine productionduring experimental infection of mice with tick-borne encephalitisvirus. Vopr. Virusol., 2003; 48: 18-21"},{"key":"152357r9","doi-asserted-by":"crossref","unstructured":"Kaiser R.: Tick-borne encephalitis: Clinical findings and prognosisin adults. Wien. Med. Wochenschr., 2012; 162: 239-243","DOI":"10.1007\/s10354-012-0105-0"},{"key":"152357r10","unstructured":"Kindberg E., Mickiene A., Ax C., Akerlind B., Vene S., LindquistL., Lundkvist A., Svensson L.: A deletion in the chemokine receptor"},{"key":"152357r11","doi-asserted-by":"crossref","unstructured":"Kristiansen T.B., Knudsen T.B., Ohlendorff S., Eugen-Olsen J.:A new multiplex PCR strategy for the simultaneous determinationof four genetic polymorphisms affecting HIV-1 disease progression.J. Immunol. Methods, 2001; 252: 147-151","DOI":"10.1016\/S0022-1759(01)00349-0"},{"key":"152357r12","doi-asserted-by":"crossref","unstructured":"Labuda M., Austyn J.M., Zuffova E., Kozuch O., Fuchsberger N.,Lysy J., Nuttall P.A.: Importance of localized skin infection in tickborneencephalitis virus transmission. Virology, 1996; 219: 357-366","DOI":"10.1006\/viro.1996.0261"},{"key":"152357r13","doi-asserted-by":"crossref","unstructured":"Li J., Liu Y., Xu F., Chen J., Chen Y.: Three polymorphisms in theIL-10 gene and the risk of HCV infection: a meta-analysis plus a ChineseAssociation Study involving 1140 subjects. Epidemiol. Infect.,2013; 141: 893-904","DOI":"10.1017\/S0950268812002154"},{"key":"152357r14","doi-asserted-by":"crossref","unstructured":"Libraty D.H., Endy T.P., Houng H.S., Green S., Kalayanarooj S.,Suntayakorn S., Chansiriwongs W., Vaughn D.W., Nisalak A., EnnisF.A., Rothman A.L.: Differing influences of virus burden and immuneactivation on disease severity in secondary dengue-3 virus infections.J. Infect. Dis., 2002; 185: 1213-1221","DOI":"10.1086\/340365"},{"key":"152357r15","doi-asserted-by":"crossref","unstructured":"Lim J.K., Louie C.Y., Glaser C., Jean C., Johnson B., Johnson H.,McDermott D.H., Murphy P.M.: Genetic deficiency of chemokine receptorCCR5 is a strong risk factor for symptomatic West Nile Virusinfection: a meta-analysis of 4 cohorts in the US epidemics. J. Infect.Dis., 2008; 197: 262-265","DOI":"10.1086\/524691"},{"key":"152357r16","doi-asserted-by":"crossref","unstructured":"Lim J.K., McDermott D.H., Lisco A., Foster G.A., Krysztof D., FollmannD., Stramer S.L., Murphy P.M.: CCR5 deficiency is a risk factorfor early clinical manifestations of West Nile virus infection but notfor viral transmission. J. Infect. Dis., 2010; 201: 178-185","DOI":"10.1086\/649426"},{"key":"152357r17","doi-asserted-by":"crossref","unstructured":"Liu R., Paxton W.A., Choe S., Ceradini D., Martin S.R., Horuk R.,MacDonald M.E., Stuhlmann H., Koup R.A., Landau N.R.: Homozygousdefect in HIV-1 coreceptor accounts for resistance of some multiply-exposedindividuals to HIV-1 infection. Cell, 1996; 86: 367-377","DOI":"10.1016\/S0092-8674(00)80110-5"},{"key":"152357r18","doi-asserted-by":"crossref","unstructured":"Loeb M., Eskandarian S., Rupp M., Fishman N., Gasink L., PattersonJ., Bramson J., Hudson T.J., Lemire M.: Genetic variants andsusceptibility to neurological complications following West Nilevirus infection. J. Infect. Dis., 2011; 204: 1031-1037","DOI":"10.1093\/infdis\/jir493"},{"key":"152357r19","doi-asserted-by":"crossref","unstructured":"Lucotte G.: Frequencies of 32 base pair deletion of the (\u039432) alleleof the CCR5 HIV-1 co-receptor gene in Caucasians: a comparativeanalysis. Infect. Genet. Evol., 2002; 1: 201-205","DOI":"10.1016\/S1567-1348(02)00027-8"},{"key":"152357r20","doi-asserted-by":"crossref","unstructured":"Mege J.L., Meghari S., Honstettre A., Capo C., Raoult D.: The twofaces of interleukin 10 in human infectious diseases. Lancet Infect.Dis., 2006; 6: 557-569","DOI":"10.1016\/S1473-3099(06)70577-1"},{"key":"152357r21","doi-asserted-by":"crossref","unstructured":"Patterson B.K., Czerniewski M., Andersson J., Sullivan Y., Su F.,Jiyamapa D., Burki Z., Landay A.: Regulation of CCR5 and CXCR4 expressionby type 1 and type 2 cytokines: CCR5 expression is downregulatedby IL-10 in CD4-positive lymphocytes. Clin. Immunol.,1999; 91: 254-262","DOI":"10.1006\/clim.1999.4713"},{"key":"152357r22","unstructured":"PZH, www. pzh. gov.pl (20.10.2015)"},{"key":"152357r23","doi-asserted-by":"crossref","unstructured":"Ryan E.J., Dring M., Ryan C.M., McNulty C., Stevenson N.J., LawlessM.W., Crowe J., Nolan N., Hegarty J.E., O\u2019Farrelly C.: Variant inCD209 promoter is associated with severity of liver disease in chronichepatitis C virus infection. Hum. Immunol., 2010; 71: 829-832","DOI":"10.1016\/j.humimm.2010.05.007"},{"key":"152357r24","unstructured":"SNPedia. rs 2287886. www.snpedia.com\/index.php\/Rs2287886(18.07.2015)"},{"key":"152357r25","doi-asserted-by":"crossref","unstructured":"Sun X.R., Wu J., Shi K.Q., Tang K.F.: Relationship between IL-10gene -1082A\/G and -592C\/A polymorphisms and the risk of hepatitisC infection: a meta-analysis. J. Viral. Hepat., 2013; 20: 602-611","DOI":"10.1111\/jvh.12082"},{"key":"152357r26","doi-asserted-by":"crossref","unstructured":"Tanaka Y., Nishida N., Sugiyama M., Kurosaki M., Matsuura K.,Sakamoto N., Nakagawa M., Korenaga M., Hino K., Hige S., Ito Y., MitaE., Tanaka E., Mochida S., Murawaki Y., et al.: Genome-wide associationof IL-28B with response to pegylated interferon-\u03b1 and ribavirintherapy for chronic hepatitis C. Nat. Genet., 2009; 41: 1105-1109","DOI":"10.1038\/ng.449"},{"key":"152357r27","doi-asserted-by":"crossref","unstructured":"Ubol S., Masrinoul P., Chaijaruwanich J., Kalayanarooj S., CharoensirisuthikulT., Kasisith J.: Differences in global gene expressionin peripheral blood mononuclear cells indicate a significant role ofthe innate responses in progression of dengue fever but not denguehaemorrhagic fever. J. Infect. Dis., 2008; 197: 1459-1467","DOI":"10.1086\/587699"},{"key":"152357r28","doi-asserted-by":"crossref","unstructured":"Wang L., Chen R.F., Liu J.W., Lee I.K., Lee C.P., Kuo H.C., HuangS.K., Yang K.D.: DC-SIGN (CD209) Promoter -336 A\/G polymorphismis associated with dengue hemorrhagic fever and correlated to DCSIGNexpression and immune augmentation. PLoS Negl. Trop. Dis.,2011; 5: e934","DOI":"10.1371\/journal.pntd.0000934"},{"key":"152357r29","doi-asserted-by":"crossref","unstructured":"Zambito Marsala S., Pistacchi M., Gioulis M., Mel R., Marchini C.,Francavilla E.: Neurological complications of tick borne encephalitis:the experience of 89 patients studied and literature review. Neurol.Sci., 2014; 35: 15-21","DOI":"10.1007\/s10072-013-1565-8"}],"container-title":["Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej"],"original-title":[],"link":[{"URL":"http:\/\/phmd.pl\/gicid\/pdf\/01.3001.0010.3856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T09:58:05Z","timestamp":1630576685000},"score":1,"resource":{"primary":{"URL":"http:\/\/phmd.pl\/gicid\/01.3001.0010.3856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,4]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,8,28]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0010.3856","relation":{},"ISSN":["0032-5449","1732-2693"],"issn-type":[{"value":"0032-5449","type":"print"},{"value":"1732-2693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,4]]}}}