{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T22:07:10Z","timestamp":1790028430242,"version":"4.0.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T00:00:00Z","timestamp":1559520000000},"content-version":"vor","delay-in-days":579,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.5604\/01.3001.0010.5280","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T03:07:39Z","timestamp":1508209659000},"page":"893-900","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Burden of Chronic Viral Hepatitis and Liver Cirrhosis in Brazil - the Brazilian Global Burden of Disease Study"],"prefix":"10.1016","volume":"16","author":[{"given":"Juliana R.","family":"de Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane A.","family":"Villela-Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata M","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia B","family":"Portugal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa S.","family":"Flor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f4nica R.","family":"Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce M.A.","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.5604\/01.3001.0010.5280_bib0010","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2893.2003.00487.x","article-title":"Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures","volume":"11","author":"Lavanchy","year":"2004","journal-title":"J Viral Hepat"},{"issue":"Suppl. 2","key":"10.5604\/01.3001.0010.5280_bib0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1478-3231.2011.02538.x","article-title":"Trends and projections of hepatitis C virus epidemiology in Latin America","volume":"31","author":"Kershenobich","year":"2011","journal-title":"Liver Int"},{"key":"10.5604\/01.3001.0010.5280_bib0020","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.jhep.2007.01.025","article-title":"Worldwide mortality from cirrhosis: an update to 2002","volume":"46","author":"Bosetti","year":"2007","journal-title":"J Hepatol"},{"issue":"Suppl. 2","key":"10.5604\/01.3001.0010.5280_bib0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1478-3231.2011.02539.x","article-title":"A systematic review of hepatitis C virus epidemiology in Europe, Canada and Israel","volume":"31","author":"Cornberg","year":"2011","journal-title":"Liver Int"},{"issue":"Suppl. 2","key":"10.5604\/01.3001.0010.5280_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1478-3231.2011.02540.x","article-title":"A systematic review of hepatitis C virus epidemiology in Asia, Australia and Egypt","volume":"31","author":"Sievert","year":"2011","journal-title":"Liver Int"},{"key":"10.5604\/01.3001.0010.5280_bib0035","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5280_bib0040","first-page":"117","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","year":"2014","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5280_bib0045","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jhep.2005.10.013","article-title":"Natural history and prognostic indicators of survival in cirrhosis: a systematic review of 118 studies","volume":"44","author":"D\u2019Amico","year":"2006","journal-title":"J Hepatol"},{"key":"10.5604\/01.3001.0010.5280_bib0050","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpg.2006.07.001","article-title":"Non-invasive diagnosis of cirrhosis and the natural history of its complications","volume":"21","author":"de Franchis","year":"2007","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.5604\/01.3001.0010.5280_bib0055","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.jhep.2014.07.012","article-title":"Natural history of hepatitis C","volume":"61","author":"Westbrook","year":"2014","journal-title":"J Hepatol"},{"key":"10.5604\/01.3001.0010.5280_bib0060","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cld.2010.05.007","article-title":"Natural history of chronic hepatitis B","volume":"14","author":"McMahon","year":"2010","journal-title":"Clin Liver Dis"},{"key":"10.5604\/01.3001.0010.5280_bib0065","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4254\/wjh.v4.i3.66","article-title":"Liver diseases in developing countries","volume":"4","author":"Cainelli","year":"2012","journal-title":"World J Hepatol"},{"key":"10.5604\/01.3001.0010.5280_bib0070","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/liv.12470","article-title":"Burden of liver disease in Brazil","volume":"34","author":"Nader","year":"2014","journal-title":"Liver Int"},{"key":"10.5604\/01.3001.0010.5280_bib0075","series-title":"The Global Burden of Disease: a comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020","author":"Murray","year":"1996"},{"key":"10.5604\/01.3001.0010.5280_bib0080","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1590\/0102-311X00111614","article-title":"Burden of disease in Brazil and its regions, 2008","volume":"31","author":"Leite","year":"2015","journal-title":"Cad Saude Publica"},{"key":"10.5604\/01.3001.0010.5280_bib0085","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1590\/S0102-311X2010000900003","article-title":"Methodology of a nationwide cross-sectional survey of prevalence and epide-miological patterns of hepatitis A, B and C infection in Brazil","volume":"26","author":"Ximenes","year":"2010","journal-title":"Cad Saude Publica"},{"key":"10.5604\/01.3001.0010.5280_bib0090","series-title":"Estudo de Preval\u00eancia de Base Populacional das Infec\u00e7\u00f5es pelos V\u00edrus das Hepatites A, B e C","author":"Pereira","year":"2010"},{"key":"10.5604\/01.3001.0010.5280_bib0095","first-page":"269","article-title":"Estimated Prevalence of Viral Hepatitis in the General Population of the Municipality of Sao Paulo, Measured by a Serologic Survey of a Stratified, Randomized and Residence-Based Population","volume":"2","author":"Focaccia","year":"1998","journal-title":"Braz J Infect Dis"},{"key":"10.5604\/01.3001.0010.5280_bib0100","first-page":"439","article-title":"DALYs: the age-weights on balance","volume":"74","author":"Barendregt","year":"1996","journal-title":"Bull World Health Organ"},{"key":"10.5604\/01.3001.0010.5280_bib0105","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DA-LYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5280_bib0110","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1016\/S0140-6736(12)61729-2","article-title":"Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Vos","year":"2012","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5280_bib0115","doi-asserted-by":"crossref","first-page":"e453","DOI":"10.1111\/j.1365-2893.2011.01467.x","article-title":"Burden of disease related to hepatitis C and hepatitis B in Spain: a methodological challenge of an unfolding health problem","volume":"18","author":"Garcia-Fulgueiras","year":"2011","journal-title":"J Viral Hepat"},{"key":"10.5604\/01.3001.0010.5280_bib0120","series-title":"Global Status Report on Alcohol and Health","year":"2014"},{"key":"10.5604\/01.3001.0010.5280_bib0125","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1111\/add.12899","article-title":"Global statistics on addictive behaviours: 2014 status report","volume":"110","author":"Gowing","year":"2015","journal-title":"Addiction"},{"key":"10.5604\/01.3001.0010.5280_bib0130","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/S0140-6736(13)61530-5","article-title":"Global burden of disease attributable to illicit drug use and dependence: findings from the Global Burden of Disease Study 2010","volume":"382","author":"Degenhardt","year":"2013","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5280_bib0135","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1016\/S0140-6736(09)60746-7","article-title":"Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders","volume":"373","author":"Rehm","year":"2009","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5280_bib0140","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1590\/1413-81232015202.01142014","article-title":"Disease burden in Brazil: an investigation into alcohol and non-viral cirrhosis","volume":"20","author":"Portugal","year":"2015","journal-title":"Cien Saude Colet"},{"key":"10.5604\/01.3001.0010.5280_bib0145","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1471-2334-13-60","article-title":"Prevalence and risk factors of Hepatitis C virus infection in Brazil, 2005 through 2009: a cross-sectional study","volume":"13","author":"Pereira","year":"2013","journal-title":"BMC Infect Dis"},{"key":"10.5604\/01.3001.0010.5280_bib0150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-230X-2-18","article-title":"Risk factors for hepatitis C virus infection among blood donors in southern Brazil: a case-control study","volume":"2","author":"Brandao","year":"2002","journal-title":"BMC Gastroenterol"},{"key":"10.5604\/01.3001.0010.5280_bib0155","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1590\/S1413-86702003000600009","article-title":"Comparative study of hepatitis C virus genotypes 1 and 3 in Salvador, Bahia Brazil","volume":"7","author":"Codes","year":"2003","journal-title":"Braz J Infect Dis"},{"key":"10.5604\/01.3001.0010.5280_bib0160","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7326\/0003-4819-156-4-201202210-00004","article-title":"The increasing burden of mortality from viral hepatitis in the United States between 1999 and 2007","volume":"156","author":"Ly","year":"2012","journal-title":"Ann Intern Med"},{"key":"10.5604\/01.3001.0010.5280_bib0165","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global Epidemiology of Non-Alcoholic Fatty Liver Disease-Meta-Analytic Assessment of Prevalence, Incidence and Outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5280_bib0170","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/1751-2980.12291","article-title":"Nonalcoholic fatty liver disease - current status and future directions","volume":"16","author":"Demir","year":"2015","journal-title":"J Dig Dis"},{"issue":"Suppl.","key":"10.5604\/01.3001.0010.5280_bib0175","article-title":"Applying a system approach to forecast the total hepatitis C virus-infected population size: model validation using US data","volume":"31","author":"Kershenobich","year":"2011","journal-title":"Liver Int"},{"key":"10.5604\/01.3001.0010.5280_bib0180","first-page":"168","article-title":"Prevalence of hepatitis C virus in urban and rural populations of northeast Brazil-pilot study","volume":"32","author":"Silva","year":"1995","journal-title":"Arq Gastroenterol"},{"key":"10.5604\/01.3001.0010.5280_bib0185","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1111\/j.1478-3231.2011.02494.x","article-title":"Hepatitis C virus infection in USA: an estimate of true prevalence","volume":"31","author":"Chak","year":"2011","journal-title":"Liver Int"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119304569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119304569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:35:49Z","timestamp":1761647749000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268119304569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":36,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S1665268119304569"],"URL":"https:\/\/doi.org\/10.5604\/01.3001.0010.5280","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Burden of Chronic Viral Hepatitis and Liver Cirrhosis in Brazil - the Brazilian Global Burden of Disease Study","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.5604\/01.3001.0010.5280","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.","name":"copyright","label":"Copyright"}]}}