{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:28:15Z","timestamp":1790810895972,"version":"4.1.0"},"reference-count":129,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,10]],"date-time":"2019-06-10T00:00:00Z","timestamp":1560124800000},"content-version":"vor","delay-in-days":586,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.5604\/01.3001.0010.5495","type":"journal-article","created":{"date-parts":[[2017,10,28]],"date-time":"2017-10-28T09:09:37Z","timestamp":1509181777000},"page":"S27-S42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":240,"special_numbering":"S1","title":["Cholesterol and Lipoprotein Metabolism and Atherosclerosis: Recent Advances in Reverse Cholesterol Transport"],"prefix":"10.1016","volume":"16","author":[{"given":"Helen H.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Garruti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piero","family":"Portincasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Q.-H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.5604\/01.3001.0010.5495_bib0005","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"key":"10.5604\/01.3001.0010.5495_bib0010","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1001\/jama.2009.1619","article-title":"Major lipids, apoli-poproteins, and risk of vascular disease","volume":"302","author":"Emerging Risk Factors","year":"2009","journal-title":"JAMA"},{"key":"10.5604\/01.3001.0010.5495_bib0015","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(10)61350-5","article-title":"Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials","volume":"376","author":"Cholesterol Treatment Trialists","year":"2010","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5495_bib0020","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jacc.2004.07.001","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines","volume":"44","author":"Grundy","year":"2004","journal-title":"J Am Coll Cardiol"},{"key":"10.5604\/01.3001.0010.5495_bib0025","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1161\/CIRCULATIONAHA.106.174516","article-title":"AHA\/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute","volume":"113","author":"Smith","year":"2006","journal-title":"Circulation"},{"key":"10.5604\/01.3001.0010.5495_bib0030","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1161\/01.CIR.0000133317.49796.0E","article-title":"Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines","volume":"110","author":"Grundy","year":"2004","journal-title":"Circulation"},{"key":"10.5604\/01.3001.0010.5495_bib0035","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1161\/01.ATV.0000054658.91146.64","article-title":"Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis","volume":"23","author":"Barter","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.5604\/01.3001.0010.5495_bib0040","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1146\/annurev.physiol.69.031905.160725","article-title":"Regulation of intestinal cholesterol absorption","volume":"69","author":"Wang","year":"2007","journal-title":"Annu Rev Physiol"},{"key":"10.5604\/01.3001.0010.5495_bib0045","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)","volume":"285","author":"Panel","year":"2001","journal-title":"JAMA"},{"key":"10.5604\/01.3001.0010.5495_bib0050","doi-asserted-by":"crossref","first-page":"e50","DOI":"10.1016\/j.jacc.2010.09.001","article-title":"2010 ACCF\/AHA guideline for assessment of cardiovascular risk in asymptomatic adults: a report of the American College of Cardiology Foundation\/ American Heart Association Task Force on Practice Guidelines","volume":"56","author":"Greenland","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.5604\/01.3001.0010.5495_bib0055","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.amjcard.2012.03.023","article-title":"Waiting for the National Cholesterol Education Program Adult Treatment Panel IV Guidelines, and in the meantime, some challenges and recommendations","volume":"110","author":"Martin","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.5604\/01.3001.0010.5495_bib0060","doi-asserted-by":"crossref","first-page":"888","DOI":"10.7326\/0003-4819-61-5-888","article-title":"Risk Factors in Coronary Heart Disease. An Evaluation of Several Serum Lipids as Predictors of Coronary Heart Disease; the Framingham Study","volume":"61","author":"Kannel","year":"1964","journal-title":"Ann Intern Med"},{"key":"10.5604\/01.3001.0010.5495_bib0065","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1172\/JCI114558","article-title":"Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit","volume":"85","author":"Badimon","year":"1990","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0070","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1016\/S0021-9258(17)40301-2","article-title":"Regulation of sterol synthesis in 16 tissues of rat. I. Effect of diurnal light cycling, fasting, stress, manipulation of enterohepatic circulation, and administration of chylomicrons and triton","volume":"252","author":"Andersen","year":"1977","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0075","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1016\/S0021-9258(17)40302-4","article-title":"Regulation of sterol synthesis in 15 tissues of rat. II. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants","volume":"252","author":"Andersen","year":"1977","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0080","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1007\/BF01716251","article-title":"Regulation of cholesterol metabolism in man and in other species","volume":"62","author":"Dietschy","year":"1984","journal-title":"Klin Wochenschr"},{"key":"10.5604\/01.3001.0010.5495_bib0085","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0005-2760(85)90063-3","article-title":"Rates of cholesterol synthesis and low-density lipoprotein uptake in the adrenal glands of the rat, hamster and rabbit in vivo","volume":"836","author":"Spady","year":"1985","journal-title":"Biochim Biophys. Acta"},{"key":"10.5604\/01.3001.0010.5495_bib0090","series-title":"The Liver: Biology and Pathobiology","first-page":"617","article-title":"The metabolism and excretion of cholesterol by the liver","author":"Turley","year":"1988"},{"key":"10.5604\/01.3001.0010.5495_bib0095","series-title":"The Liver: Biology and Pathobiology","first-page":"271","article-title":"Lipoprotein Metabolism and Cholesterol Balance","author":"Cohen","year":"2009"},{"key":"10.5604\/01.3001.0010.5495_bib0100","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1074\/jbc.R100057200","article-title":"Control of cholesterol turnover in the mouse","volume":"277","author":"Dietschy","year":"2002","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0105","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0022-2275(20)34361-3","article-title":"Rates of low density li-poprotein uptake and cholesterol synthesis are regulated independently in the liver","volume":"26","author":"Spady","year":"1985","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0110","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1172\/JCI112066","article-title":"Receptor-independent low density lipoprotein transport in the rat in vivo. Quantita-tion, characterization, and metabolic consequences","volume":"76","author":"Spady","year":"1985","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1097\/00041433-200306000-00002","article-title":"Sterol absorption by the small intestine","volume":"14","author":"Turley","year":"2003","journal-title":"Curr Opin Lipidol"},{"key":"10.5604\/01.3001.0010.5495_bib0120","series-title":"Lipidology in the Treatment and Prevention of Cardiovascular Disease (Clinical Lipidology: A Companion to Braunwald\u2019s Heart Disease)","first-page":"26","article-title":"Absorption and Excretion of Cholesterol and Other Sterols","author":"Wang","year":"2008"},{"key":"10.5604\/01.3001.0010.5495_bib0125","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0361-9230(91)90145-A","article-title":"The absorption and transport of lipids by the small intestine","volume":"27","author":"Tso","year":"1991","journal-title":"Brain Res Bull"},{"key":"10.5604\/01.3001.0010.5495_bib0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/hep.22286","article-title":"Physical chemistry of intestinal absorption of biliary cholesterol in mice","volume":"48","author":"Wang","year":"2008","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5495_bib0135","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/S0022-2275(20)31508-X","article-title":"Genetic factors at the ente-rocyte level account for variations in intestinal cholesterol absorption efficiency among inbred strains of mice","volume":"42","author":"Wang","year":"2001","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0140","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0021-9150(87)90262-0","article-title":"Relationships between dietary cholesterol, cholesterol absorption, cholesterol synthesis, and plasma cholesterol in rhesus monkeys","volume":"67","author":"Bhattacharyya","year":"1987","journal-title":"Atherosclerosis"},{"key":"10.5604\/01.3001.0010.5495_bib0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0005-2760(98)00174-X","article-title":"Impact of beta-cyclodextrin and resistant starch on bile acid metabolism and fecal steroid excretion in regard to their hy-polipidemic action in hamsters","volume":"1437","author":"Trautwein","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.5604\/01.3001.0010.5495_bib0150","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/00005344-199601000-00012","article-title":"Effect of feeding psyllium and cholestyramine in combination on low density lipoprotein metabolism and fecal bile acid excretion in hamsters with dietary-induced hypercholesterolemia","volume":"27","author":"Turley","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.5604\/01.3001.0010.5495_bib0155","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/0026-0495(91)90131-F","article-title":"Cholesterol-lowering action of psyllium mucilloid in the hamster: sites and possible mechanisms of action","volume":"40","author":"Turley","year":"1991","journal-title":"Metabolism"},{"key":"10.5604\/01.3001.0010.5495_bib0160","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.1093131","article-title":"Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption","volume":"303","author":"Altmann","year":"2004","journal-title":"Science"},{"key":"10.5604\/01.3001.0010.5495_bib0165","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbalip.2009.01.002","article-title":"Niemann-Pick C1 Like 1 (NPC1L1) an intestinal sterol transporter","volume":"1791","author":"Davis","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.5604\/01.3001.0010.5495_bib0170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.atherosclerosissup.2008.05.008","article-title":"Cholesterol homeostasis by the intestine: lessons from Niemann-Pick C1 Like 1 [NPC1L1)","volume":"9","author":"Davis","year":"2008","journal-title":"Atheroscler Suppl"},{"key":"10.5604\/01.3001.0010.5495_bib0175","doi-asserted-by":"crossref","first-page":"33586","DOI":"10.1074\/jbc.M405817200","article-title":"Niemann-Pick C1 Like 1 (NPC1L1) is the intestinal phytosterol and cholesterol transporter and a key modulator of whole-body cholesterol homeostasis","volume":"279","author":"Davis","year":"2004","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0180","doi-asserted-by":"crossref","first-page":"8132","DOI":"10.1073\/pnas.0500269102","article-title":"The target of ezetimibe is Nie-mann-Pick C1-Like 1 (NPC1L1)","volume":"102","author":"Garcia-Calvo","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.5604\/01.3001.0010.5495_bib0185","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1126\/science.290.5497.1771","article-title":"Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters","volume":"290","author":"Berge","year":"2000","journal-title":"Science"},{"key":"10.5604\/01.3001.0010.5495_bib0190","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0022-2275(20)30155-3","article-title":"Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8","volume":"43","author":"Berge","year":"2002","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0195","doi-asserted-by":"crossref","first-page":"24881","DOI":"10.1074\/jbc.M402634200","article-title":"Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking","volume":"279","author":"Graf","year":"2004","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0200","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1172\/JCI0216000","article-title":"Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface","volume":"110","author":"Graf","year":"2002","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0205","doi-asserted-by":"crossref","first-page":"48275","DOI":"10.1074\/jbc.M310223200","article-title":"ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion","volume":"278","author":"Graf","year":"2003","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0210","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/humu.1206","article-title":"Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia","volume":"18","author":"Hubacek","year":"2001","journal-title":"Hum Mutat"},{"key":"10.5604\/01.3001.0010.5495_bib0215","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1172\/JCI0216001","article-title":"Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol","volume":"110","author":"Yu","year":"2002","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0220","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/83799","article-title":"Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption","volume":"27","author":"Lee","year":"2001","journal-title":"Nat Genet"},{"key":"10.5604\/01.3001.0010.5495_bib0225","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1002\/hep.21579","article-title":"Quantifying anomalous intestinal sterol uptake, lymphatic transport, and biliary secretion in Abcg8(-\/-) mice","volume":"45","author":"Wang","year":"2007","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5495_bib0230","first-page":"G269","article-title":"Role of intestinal sterol transporters Abcg5, Abcg8, and Npc1l1 in cholesterol absorption in mice: gender and age effects","volume":"290","author":"Duan","year":"2006","journal-title":"Am J Physiol"},{"key":"10.5604\/01.3001.0010.5495_bib0235","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1194\/jlr.M400030-JLR200","article-title":"Cholesterol absorption is mainly regulated by the jejunal and ileal ATP-binding cassette sterol efflux transporters Abcg5 and Abcg8 in mice","volume":"45","author":"Duan","year":"2004","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0240","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.gastro.2004.11.017","article-title":"New insights into the genetic regulation of intestinal cholesterol absorption","volume":"129","author":"Lammert","year":"2005","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0010.5495_bib0245","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/jcp.1040850409","article-title":"Use of mutant fibroblasts in the analysis of the regulation of cholesterol metabolism in human cells","volume":"85","author":"Brown","year":"1975","journal-title":"J Cell Physiol"},{"key":"10.5604\/01.3001.0010.5495_bib0250","doi-asserted-by":"crossref","first-page":"4731","DOI":"10.1016\/S0021-9258(19)43725-3","article-title":"3-Hy-droxy-3-methylglutaryl coenzyme A reductase. Solubilization and purification of a cold-sensitive microsomal enzyme","volume":"248","author":"Brown","year":"1973","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0255","doi-asserted-by":"crossref","first-page":"2925","DOI":"10.1073\/pnas.72.8.2925","article-title":"Receptor-dependent hydrolysis of cholesteryl esters contained in plasma low density lipoprotein","volume":"72","author":"Brown","year":"1975","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.5604\/01.3001.0010.5495_bib0260","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.1016\/S0021-9258(19)41498-1","article-title":"Cholesterol ester formation in cultured human fibroblasts. Stimulation by oxygenated sterols","volume":"250","author":"Brown","year":"1975","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0265","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0021-9258(19)42998-0","article-title":"Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercho-lesterolemia","volume":"249","author":"Brown","year":"1974","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0270","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1073\/pnas.70.7.2162","article-title":"Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fi-broblasts by lipoproteins","volume":"70","author":"Brown","year":"1973","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.5604\/01.3001.0010.5495_bib0275","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0022-2275(20)34420-5","article-title":"Measurement of rates of cholesterol synthesis using tritiated water","volume":"25","author":"Dietschy","year":"1984","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0280","first-page":"177","article-title":"Regulation of low density lipoprotein uptake and degradation in different animals species","volume":"16","author":"Dietschy","year":"1984","journal-title":"Agents Actions Suppl"},{"key":"10.5604\/01.3001.0010.5495_bib0285","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1042\/bst0110639","article-title":"Quantitative importance of different organs for cholesterol synthesis and low-densi-ty-lipoprotein degradation","volume":"11","author":"Dietschy","year":"1983","journal-title":"Biochem Soc Trans"},{"key":"10.5604\/01.3001.0010.5495_bib0290","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0022-2275(20)35728-X","article-title":"Role of liver in the maintenance of cholesterol and low density lipoprotein homeosta-sis in different animal species, including humans","volume":"34","author":"Dietschy","year":"1993","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0295","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/S0022-2275(20)37178-9","article-title":"Identification of a metabolic difference accounting for the hyper- and hypore-sponder phenotypes of cynomolgus monkey","volume":"38","author":"Turley","year":"1997","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0300","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1002\/hep.510250403","article-title":"Regulation of fecal bile acid excretion in male golden Syrian hamsters fed a cereal-based diet with and without added cholesterol","volume":"25","author":"Turley","year":"1997","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5495_bib0305","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0022-2275(20)39755-8","article-title":"Role of liver in the synthesis of cholesterol and the clearance of low density lipo-proteins in the cynomolgus monkey","volume":"36","author":"Turley","year":"1995","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0310","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0022-2275(20)37999-2","article-title":"Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat","volume":"24","author":"Spady","year":"1983","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0315","doi-asserted-by":"crossref","first-page":"8742","DOI":"10.1074\/jbc.M411080200","article-title":"Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion","volume":"280","author":"Yu","year":"2005","journal-title":"J Biol Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0320","doi-asserted-by":"crossref","first-page":"16237","DOI":"10.1073\/pnas.252582399","article-title":"Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion","volume":"99","author":"Yu","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.5604\/01.3001.0010.5495_bib0325","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1741-7015-2-5","article-title":"A mouse model of sitosterolemia: absence of Abcg8\/sterolin-2 results in failure to secrete biliary cholesterol","volume":"2","author":"Klett","year":"2004","journal-title":"BMC Med"},{"key":"10.5604\/01.3001.0010.5495_bib0330","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0168-8278(03)00093-X","article-title":"Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice","volume":"38","author":"Kosters","year":"2003","journal-title":"J Hepatol"},{"key":"10.5604\/01.3001.0010.5495_bib0335","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2362.2010.02300.x","article-title":"Transgenic overexpression of Abcb11 enhances biliary bile salt outputs, but does not affect cholesterol cholelithogenesis in mice","volume":"40","author":"Wang","year":"2010","journal-title":"Eur J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0340","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1172\/JCI105794","article-title":"The physicochemical basis of cholesterol gallstone formation in man","volume":"47","author":"Admirand","year":"1968","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0345","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1172\/JCI109025","article-title":"The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man","volume":"61","author":"Carey","year":"1978","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0350","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/S0022-2275(20)37458-7","article-title":"Characterization of crystallization pathways during cholesterol precipitation from human gallbladder biles: identical pathways to corresponding model biles with three predominating sequences","volume":"37","author":"Wang","year":"1996","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0355","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S0022-2275(20)32445-7","article-title":"No patho-physiologic relationship of soluble biliary proteins to cholesterol crystallization in human bile","volume":"40","author":"Wang","year":"1999","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0360","first-page":"181","article-title":"Lipoprotein receptors, cholesterol metabolism, and atherosclerosis","volume":"99","author":"Goldstein","year":"1975","journal-title":"Arch Pathol"},{"key":"10.5604\/01.3001.0010.5495_bib0365","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/scientificamerican1184-58","article-title":"How LDL receptors influence cholesterol and atherosclerosis","volume":"251","author":"Brown","year":"1984","journal-title":"Sci Am"},{"key":"10.5604\/01.3001.0010.5495_bib0370","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.bi.52.070183.001255","article-title":"Lipoprotein metabolism in the mac-rophage: implications for cholesterol deposition in atherosclerosis","volume":"52","author":"Brown","year":"1983","journal-title":"Annu Rev Biochem"},{"key":"10.5604\/01.3001.0010.5495_bib0375","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1126\/science.6261329","article-title":"Regulation of plasma cholesterol by lipoprotein receptors","volume":"212","author":"Brown","year":"1981","journal-title":"Science"},{"key":"10.5604\/01.3001.0010.5495_bib0380","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1056\/NEJM197710202971608","article-title":"Cellular mechanisms for lipid deposition in atherosclerosis (first of two parts)","volume":"297","author":"Small","year":"1977","journal-title":"N Engl J Med"},{"key":"10.5604\/01.3001.0010.5495_bib0385","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1161\/01.ATV.8.2.103","article-title":"George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry","volume":"8","author":"Small","year":"1988","journal-title":"Arteriosclerosis"},{"key":"10.5604\/01.3001.0010.5495_bib0390","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1126\/science.185.4147.222","article-title":"Physical-chemical basis of lipid deposition in atherosclerosis","volume":"185","author":"Small","year":"1974","journal-title":"Science"},{"key":"10.5604\/01.3001.0010.5495_bib0395","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1161\/01.CIR.76.3.504","article-title":"Regulation of low-density lipopro-tein receptors: implications for pathogenesis and therapy of hypercholesterolemia and atherosclerosis","volume":"76","author":"Goldstein","year":"1987","journal-title":"Circulation"},{"key":"10.5604\/01.3001.0010.5495_bib0400","series-title":"Biliary Lithiasis: Basic Science, Current Diagnosis and Management","first-page":"19","article-title":"Pathophysiology and Cholesterol Gallstone Disease","author":"Portincasa","year":"2008"},{"key":"10.5604\/01.3001.0010.5495_bib0405","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/S0140-6736(06)69044-2","article-title":"Cholesterol gallstone disease","volume":"368","author":"Portincasa","year":"2006","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5495_bib0410","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S1665-2681(19)32170-2","article-title":"From lipid secretion to cholesterol crystallization in bile. Relevance in cholesterol gallstone disease","volume":"1","author":"Portincasa","year":"2002","journal-title":"Ann Hepatol"},{"key":"10.5604\/01.3001.0010.5495_bib0415","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S1590-8658(03)00009-4","article-title":"Pathways of cholesterol crystallization in model bile and native bile","volume":"3","author":"Portincasa","year":"2003","journal-title":"Dig Liver Dis"},{"key":"10.5604\/01.3001.0010.5495_bib0420","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/hep.1840110426","article-title":"Cholesterol crystal nucleation: a decade-long search for the missing link in gallstone pathogene-sis","volume":"11","author":"Afdhal","year":"1990","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5495_bib0425","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0016-5085(79)90209-9","article-title":"Nucleation time: a key factor in the pathogene-sis of cholesterol gallstone disease","volume":"77","author":"Holan","year":"1979","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0010.5495_bib0430","first-page":"101","article-title":"Cholesterol nucleation in bile","volume":"27","author":"Holzbach","year":"1995","journal-title":"Ital J Gastroen-terol"},{"key":"10.5604\/01.3001.0010.5495_bib0435","first-page":"155S","article-title":"Nucleation of cholesterol crystals in native bile","volume":"12","author":"Holzbach","year":"1990","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5495_bib0440","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/hep.1840060630","article-title":"Recent progress in understanding cholesterol crystal nucleation as a precursor to human gallstone formation","volume":"6","author":"Holzbach","year":"1986","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5495_bib0445","doi-asserted-by":"crossref","first-page":"173S","DOI":"10.1002\/hep.1840040833","article-title":"Factors influencing cholesterol nucleation in bile","volume":"4","author":"Holzbach","year":"1984","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5495_bib0450","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0889-8553(21)00534-3","article-title":"Nucleation and growth of cholesterol crystals. Kinetic determinants in supersaturated native bile","volume":"20","author":"Holzbach","year":"1991","journal-title":"Gastroenterol Clin North Am"},{"key":"10.5604\/01.3001.0010.5495_bib0455","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/01.CIR.4.5.666","article-title":"Blood lipids and human atherosclerosis. II. The influence of heparin upon lipoprotein metabolism","volume":"4","author":"Graham","year":"1951","journal-title":"Circulation"},{"key":"10.5604\/01.3001.0010.5495_bib0460","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1021\/j150484a010","article-title":"The ultracentrifugal characterization and isolation of human blood lipids and lipo-proteins, with applications to the study of atherosclerosis","volume":"55","author":"Lindgren","year":"1951","journal-title":"J Phys Colloid Chem"},{"key":"10.5604\/01.3001.0010.5495_bib0465","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/9780470110171.ch16","article-title":"Ultracentrifugal analysis of serum lipoproteins","volume":"1","author":"De Lalla","year":"1954","journal-title":"Methods Biochem Anal"},{"key":"10.5604\/01.3001.0010.5495_bib0470","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1161\/01.CIR.34.4.679","article-title":"Ischemic heart disease, atherosclerosis, and longevity","volume":"34","author":"Gofman","year":"1966","journal-title":"Circulation"},{"key":"10.5604\/01.3001.0010.5495_bib0475","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0022-2275(20)39245-2","article-title":"Role of plasma lecithin:cholesterol acyltransferase in the metabolism of high density lipoproteins","volume":"7","author":"Glomset","year":"1966","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0480","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1126\/scitranslmed.3008535","article-title":"New Therapies for Coronary Artery Disease: Genetics Provides a Blueprint","volume":"6","author":"Rader","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.5604\/01.3001.0010.5495_bib0485","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/clpt.2014.79","article-title":"High-density lipoproteins in the prevention of cardiovascular disease: changing the paradigm","volume":"96","author":"Tuteja","year":"2014","journal-title":"Clin Pharmacol Ther"},{"key":"10.5604\/01.3001.0010.5495_bib0490","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S0140-6736(14)61217-4","article-title":"HDL and cardiovascular disease","volume":"384","author":"Rader","year":"2014","journal-title":"Lancet"},{"key":"10.5604\/01.3001.0010.5495_bib0495","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/cvr\/cvu164","article-title":"Spotlight on HDL biology: new insights in metabolism, function, and translation","volume":"103","author":"Rader","year":"2014","journal-title":"Cardiovasc Res"},{"key":"10.5604\/01.3001.0010.5495_bib0500","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1172\/JCI30163","article-title":"Molecular regulation of HDL metabolism and function: implications for novel therapies","volume":"116","author":"Rader","year":"2006","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0505","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1161\/CIRCULATIONAHA.113.000962","article-title":"Translation of high-density lipoprotein function into clinical practice: current prospects and future challenges","volume":"128","author":"Rosenson","year":"2013","journal-title":"Circulation"},{"key":"10.5604\/01.3001.0010.5495_bib0510","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jacl.2013.08.001","article-title":"High-density lipoproteins: a consensus statement from the National Lipid Association","volume":"7","author":"Toth","year":"2013","journal-title":"J Clin Lipidol"},{"key":"10.5604\/01.3001.0010.5495_bib0515","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.plipres.2014.07.003","article-title":"Understanding high-density lipoprotein function in disease: Recent advances in proteomics unravel the complexity of its composition and biology","volume":"56C","author":"Birner-Gruenberger","year":"2014","journal-title":"Prog Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0520","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1161\/CIRCULATIONAHA.111.066589","article-title":"Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport","volume":"125","author":"Rosenson","year":"2012","journal-title":"Circulation"},{"key":"10.5604\/01.3001.0010.5495_bib0525","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1161\/01.RES.0000170946.56981.5c","article-title":"New insights into the regulation of HDL metabolism and reverse cholesterol transport","volume":"96","author":"Lewis","year":"2005","journal-title":"Circ Res"},{"issue":"Suppl.","key":"10.5604\/01.3001.0010.5495_bib0530","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1194\/jlr.R800088-JLR200","article-title":"The role of reverse cholesterol transport in animals and humans and relationship to atherosclerosis","volume":"50","author":"Rader","year":"2009","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0535","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11883-009-0080-0","article-title":"Future therapeutic directions in reverse cholesterol transport","volume":"12","author":"Khera","year":"2010","journal-title":"Curr Atheroscler Rep"},{"key":"10.5604\/01.3001.0010.5495_bib0540","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/nrcardio.2010.200","article-title":"Novel HDL-directed pharmacothera-peutic strategies","volume":"8","author":"Degoma","year":"2011","journal-title":"Nat Rev Cardiol"},{"key":"10.5604\/01.3001.0010.5495_bib0545","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0022-2275(20)38701-0","article-title":"Interstitial fluid lipoproteins","volume":"28","author":"Sloop","year":"1987","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0550","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0022-2275(20)31173-1","article-title":"Composition and ultrastructure of size subclasses of normal human peripheral lymph lipoproteins: quantification of cholesterol uptake by HDL in tissue fluids","volume":"42","author":"Nanjee","year":"2001","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0555","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1172\/JCI63685","article-title":"Lymphatic vasculature mediates macro-phage reverse cholesterol transport in mice","volume":"123","author":"Martel","year":"2013","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0560","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.cmet.2013.04.002","article-title":"Lymphatic vessels are essential for the removal of cholesterol from peripheral tissues by SR-BI-mediated transport of HDL","volume":"17","author":"Lim","year":"2013","journal-title":"Cell Metab"},{"key":"10.5604\/01.3001.0010.5495_bib0565","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.cmet.2013.04.017","article-title":"Lymphatics as a new active player in reverse cholesterol transport","volume":"17","author":"Kahn","year":"2013","journal-title":"Cell Metab"},{"key":"10.5604\/01.3001.0010.5495_bib0570","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1172\/JCI68657","article-title":"Lymphatic vessels clean up your arteries","volume":"123","author":"Fernandez-Hernando","year":"2013","journal-title":"J Clin Invest"},{"key":"10.5604\/01.3001.0010.5495_bib0575","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s11883-013-0354-4","article-title":"Atherosclerosis and transit of HDL through the lymphatic vasculature","volume":"15","author":"Martel","year":"2013","journal-title":"Curr Atheroscler Rep"},{"key":"10.5604\/01.3001.0010.5495_bib0580","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1056\/NEJM195908202610802","article-title":"Serum cholesterol esters and intestinal cholesterol secretion and absorption in obstructive jaundice due to cancer","volume":"261","author":"Stanley","year":"1959","journal-title":"N Engl J Med"},{"key":"10.5604\/01.3001.0010.5495_bib0585","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1053\/j.gastro.2004.10.006","article-title":"Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice","volume":"128","author":"Kruit","year":"2005","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0010.5495_bib0590","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cmet.2010.05.011","article-title":"Biliary sterol secretion is not required for macrophage reverse cholesterol transport","volume":"12","author":"Temel","year":"2010","journal-title":"Cell Metab"},{"key":"10.5604\/01.3001.0010.5495_bib0595","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1053\/j.gastro.2016.12.037","article-title":"Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice","volume":"152","author":"de Boer","year":"2017","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0010.5495_bib0600","series-title":"Gastroenterology","article-title":"Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice","author":"de Boer","year":"2017"},{"key":"10.5604\/01.3001.0010.5495_bib0605","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1161\/ATVBAHA.116.308558","article-title":"Transintestinal and Biliary Cholesterol Secretion Both Contribute to Macrophage Reverse Cholesterol Transport in Rats-Brief Report","volume":"37","author":"de Boer","year":"2017","journal-title":"Arterio-scler Thromb Vasc Biol"},{"key":"10.5604\/01.3001.0010.5495_bib0610","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/ATVBAHA.112.300263","article-title":"Transintestinal cholesterol excretion is an active metabolic process modulated by PCSK9 and statin involving ABCB1","volume":"33","author":"Le May","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.5604\/01.3001.0010.5495_bib0615","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cmet.2016.10.001","article-title":"Transintestinal Cholesterol Transport Is Active in Mice and Humans and Controls Ezetimibe-Induced Fecal Neutral Sterol Excretion","volume":"24","author":"Jakulj","year":"2016","journal-title":"Cell Metab"},{"key":"10.5604\/01.3001.0010.5495_bib0620","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/hep.29341","article-title":"Transintestinal cholesterol excretion (TICE): A secondary, non-biliary pathway contributing to reverse cholesterol transport","volume":"66","author":"Wang","year":"2017","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.5495_bib0625","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJM199011013231803","article-title":"Increased high-density lipo-protein levels caused by a common cholesteryl-ester transfer protein gene mutation","volume":"323","author":"Inazu","year":"1990","journal-title":"N Engl J Med"},{"key":"10.5604\/01.3001.0010.5495_bib0630","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1097\/00041433-200012000-00004","article-title":"Pros and cons of inhibiting cholesteryl ester transfer protein","volume":"11","author":"Hirano","year":"2000","journal-title":"Curr Opin Lipidol"},{"key":"10.5604\/01.3001.0010.5495_bib0635","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1388-1981(00)00164-5","article-title":"Molecular biology and pathophysiological aspects of plasma choles-teryl ester transfer protein","volume":"1529","author":"Yamashita","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.5604\/01.3001.0010.5495_bib0640","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1194\/jlr.M300198-JLR200","article-title":"Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency","volume":"45","author":"Asztalos","year":"2004","journal-title":"J Lipid Res"},{"key":"10.5604\/01.3001.0010.5495_bib0645","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cca.2008.12.012","article-title":"Cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells to serum is preserved in CETP-deficient patients","volume":"402","author":"Miwa","year":"2009","journal-title":"Clin Chim Acta"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119310415?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119310415?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:38:15Z","timestamp":1761647895000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268119310415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":129,"alternative-id":["S1665268119310415"],"URL":"https:\/\/doi.org\/10.5604\/01.3001.0010.5495","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cholesterol and Lipoprotein Metabolism and Atherosclerosis: Recent Advances in Reverse Cholesterol Transport","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.5604\/01.3001.0010.5495","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2017 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.","name":"copyright","label":"Copyright"}]}}