{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T17:04:36Z","timestamp":1774976676216,"version":"3.50.1"},"reference-count":0,"publisher":"Walter de Gruyter GmbH","issue":"0","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Postepy Hig Med Dosw"],"published-print":{"date-parts":[[2017,11,19]]},"abstract":"<jats:p>G protein-coupled receptors (GPCRs) constitute a family of transmembrane proteins that mediate many cellular processes. GPR120\/FFAR4, a receptor from this family that is activated by fatty acids, has received considerable attention recently.\nThis paper presents a literature review concerning the role of GPR120 and its mechanism of action\nin animal and human studies as well as the potential use of GPR120 for the treatment of chronic\ndiseases.\nTwo electronic databases \u2013 Medline and Google Scholar \u2013 were searched for available studies\naddressing the review topic that were written in English and published from 2000 to June 2017.\nThe following key terms were used in the search: GPR120, FFA4, GPR120 agonist, PUFAs, EPA, DHA,\nadipocyte, obesity, hyperlipidemia, inflammation, cancer, diabetes, insulin resistance, taste, atherogenesis,\nhepatis, central nervous system.\nIn humans, GPR120 expression is expressed in macrophages, eosinophils, and adipose tissue, in cells\nof the tongue, liver, lungs, small and large intestine, gastric mucosa, and pancreas, in the central\nnervous system and placental microvilli.\nMedium- and long-chain fatty acids act as ligands for the receptor.\nThrough the internalization of beta-arrestin-2 complex and the inhibition of NF-\u03baB, GPR120 mediates\nthe activation of the cell\u2019s anti-inflammatory mechanisms.\nThe receptor is also involved in the maturation of adipocytes, the modulation of insulin signalling\npathways, the regulation of glucose metabolism, and the secretion of intestinal hormones.\nGPR120 is a promising target for the treatment of numerous diseases, whose pathophysiology\nis associated with low-grade inflammation. As a result of intensive searches, a likely group of\nsynthetic agonists of the receptor was determined with potential therapeutic applications in\nconditions such as obesity, impaired carbohydrate metabolism, inflammatory bowel diseases,\ncancer, mental disorders.\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0010.5809","type":"journal-article","created":{"date-parts":[[2017,11,19]],"date-time":"2017-11-19T17:20:42Z","timestamp":1511112042000},"page":"0-0","source":"Crossref","is-referenced-by-count":15,"title":["GPR120: Mechanism of action, role and potential for medical applications"],"prefix":"10.2478","volume":"71","author":[{"given":"Hanna","family":"Karaku\u0142a-Juchnowicz","sequence":"first","affiliation":[{"name":"I Klinika Psychiatrii, Psychoterapii i Wczesnej Interwencji Uniwersytetu Medycznego w Lublinie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"R\u00f3g","sequence":"additional","affiliation":[{"name":"Wydzia\u0142 Nauk o \u017bywieniu Cz\u0142owieka i Konsumpcji, Szko\u0142a G\u0142\u00f3wna Gospodarstwa Wiejskiego w Warszawie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dariusz","family":"Juchnowicz","sequence":"additional","affiliation":[{"name":"Zak\u0142ad Piel\u0119gniarstwa Psychiatrycznego Uniwersytetu Medycznego w Lublinie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Morylowska-Topolska","sequence":"additional","affiliation":[{"name":"Zak\u0142ad Neuropsychiatrii Klinicznej Uniwersytetu Medycznego w Lublinie"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"374","container-title":["Post\u0119py Higieny i Medycyny Do\u015bwiadczalnej"],"original-title":[],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T09:56:30Z","timestamp":1630576590000},"score":1,"resource":{"primary":{"URL":"http:\/\/phmd.pl\/gicid\/01.3001.0010.5809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,19]]},"references-count":0,"journal-issue":{"issue":"0","published-print":{"date-parts":[[2017,11,19]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0010.5809","relation":{},"ISSN":["0032-5449","1732-2693"],"issn-type":[{"value":"0032-5449","type":"print"},{"value":"1732-2693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,19]]}}}