{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T19:36:46Z","timestamp":1781206606408,"version":"3.54.1"},"reference-count":0,"publisher":"Index Copernicus","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol Pol"],"published-print":{"date-parts":[[2017,12,30]]},"abstract":"<jats:p>Laryngopharyngeal reflux (LPR) is a common defect among laryngological and phoniatric patients. Although LPR is\ncategorized as a superficial gastroesophageal reflux disease (GERD), differential diagnosis should treat these two diseases\nseparately. LPR symptoms can be assessed in the interview using as a tool the reflux symptom index (RSI). In addition,\nchanges in the larynx that occur during LPR might be seen during laryngoscopy and classified according to the\nreflux finding score (RFS). One of the main mucosal irritants in LPR is pepsin which digests proteins and impairs the\nfunctions of the upper respiratory tract cells by affecting carbonate anhydrase (CAIII) and the Sep 70 protein. Pepsin\ninitiates inflammatory changes within the larynx, nasopharynx and nasal cavity. The use of pepsin detection in upper\nand lower throat secretions is a new direction in LPR diagnostics.\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0010.7194","type":"journal-article","created":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T16:22:35Z","timestamp":1513354955000},"page":"7-13","source":"Crossref","is-referenced-by-count":22,"title":["The role of pepsin in the laryngopharyngeal reflux"],"prefix":"10.5604","volume":"71","author":[{"given":"Katarzyna","family":"Kowalik","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Division of Medicine and Dentistry, Medical University of Warsaw; Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoni","family":"Krzeski","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Division of Medicine and Dentistry, Medical University of Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","container-title":["Otolaryngologia Polska"],"original-title":[],"deposited":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T16:22:38Z","timestamp":1513354958000},"score":1,"resource":{"primary":{"URL":"http:\/\/otolaryngologypl.com\/gicid\/01.3001.0010.7194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,30]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,12,30]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0010.7194","relation":{},"ISSN":["0030-6657","2300-8423"],"issn-type":[{"value":"0030-6657","type":"print"},{"value":"2300-8423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,30]]}}}