{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:43:38Z","timestamp":1761648218637,"version":"build-2065373602"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T00:00:00Z","timestamp":1557100800000},"content-version":"vor","delay-in-days":490,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.5604\/01.3001.0010.7531","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T18:53:49Z","timestamp":1514400829000},"page":"14-17","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Changing Face of the Diagnosis of Chronic and Malignant Liver Diseases: Potential New Biomarkers"],"prefix":"10.1016","volume":"17","author":[{"given":"Vania","family":"Cruz-Ram\u00f3n","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Chinchilla-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Ram\u00edrez-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingshun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahum","family":"M\u00e9ndez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.5604\/01.3001.0010.7531_bib0005","first-page":"332","article-title":"Epidemiology of hepatocellular carcinoma in the Asia-Pacific region","volume":"3","author":"Zhu","year":"2016","journal-title":"Gut Liver"},{"key":"10.5604\/01.3001.0010.7531_bib0010","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bpg.2015.02.003","article-title":"Epidemiology of cholangiocarcinoma","volume":"2","author":"Bergquist","year":"2015","journal-title":"Best Pract Res Clin Gastroenteroi"},{"key":"10.5604\/01.3001.0010.7531_bib0015","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1002\/hep.24247","article-title":"Incidence of primary sclerosing cholangitis: a systematic review and meta-analysis","volume":"5","author":"Molodecky","year":"2011","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.7531_bib0020","doi-asserted-by":"crossref","first-page":"565","DOI":"10.5604\/01.3001.0010.0293","article-title":"Prevalence, risk factors, and survival of patients with intrahepatic cholangiocarcinoma","volume":"4","author":"Chinchilla-L\u00f3pez","year":"2017","journal-title":"Ann Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0025","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrgastro.2016.51","article-title":"Expert consensus document: Cholangiocarcinoma: current knowledge and future perspectives consensus statement from the European Network for the Study of Cholangiocarcinoma (ENS-CCA)","volume":"5","author":"Banales","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0030","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/MCG.0b013e3182872f29","article-title":"Epidemiology of HCC: consider the population","volume":"47","author":"Mittal","year":"2013","journal-title":"J Clin Gastroenterol"},{"key":"10.5604\/01.3001.0010.7531_bib0035","first-page":"1159","article-title":"Comparison of incidence of intrahepatic and extrahepatic cholangiocarcinoma - focus on East and South-Eastern Asia","volume":"5","author":"Shin","year":"2010","journal-title":"Asian Pac J Cancer Prev"},{"key":"10.5604\/01.3001.0010.7531_bib0040","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/S1665-2681(19)32086-1","article-title":"Trends in liver disease prevalence in Mexico from 2005 to 2050 through mortality data","volume":"1","author":"M\u00e9ndez-S\u00e1nchez","year":"2005","journal-title":"Ann Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0045","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1665-2681(19)32034-4","article-title":"Hepatocellular carcinoma. An overview","volume":"1","author":"Motola-Kuba","year":"2006","journal-title":"Ann Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0050","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1665-2681(19)31913-1","article-title":"Hepatocellular carcinoma in Hispanics","volume":"6","author":"M\u00e9ndez-S\u00e1nchez","year":"2007","journal-title":"Ann Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0055","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S1665-2681(19)31852-6","article-title":"Mortality trends for liver cancer in Mexico from 2000 to 2006","volume":"3","author":"M\u00e9ndez-S\u00e1nchez","year":"2008","journal-title":"Ann Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0060","first-page":"106247","article-title":"Nonalcoholic fatty liver disease and hepatocellular carcinoma","volume":"2014","author":"Kikuchi","year":"2014","journal-title":"Bio Med Res Int"},{"key":"10.5604\/01.3001.0010.7531_bib0065","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1053\/j.gastro.2011.12.061","article-title":"Epidemiology of viral hepatitis and hepatocellular carcinoma","volume":"6","author":"El-Serag","year":"2012","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0010.7531_bib0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/13651820801992641","article-title":"Epidemiology, risk factors, and pathogenesis of cholangiocarcinoma","volume":"2","author":"Khan","year":"2008","journal-title":"HPB (Oxford)"},{"key":"10.5604\/01.3001.0010.7531_bib0075","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/jnci\/djj234","article-title":"Impact of classification of hilar cholangiocarcinomas (Klatskin tumors) on the incidence of intra- and extrahepatic cholangiocarcinoma in the United States","volume":"12","author":"Welzel","year":"2006","journal-title":"Natl Cancer Inst"},{"key":"10.5604\/01.3001.0010.7531_bib0080","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.dld.2009.10.009","article-title":"AISF Cholangiocarcinoma committee. Descriptive epidemiology of cholangiocarcinoma in Italy","volume":"7","author":"Alvaro","year":"2010","journal-title":"Dig Liver Dis"},{"key":"10.5604\/01.3001.0010.7531_bib0085","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0959-8049(03)00544-6","article-title":"Do increases in mortality from intrahepatic cholangiocarcinoma reflect a genuine increase in risk? Insights from cancer registry data in Scotland","volume":"14","author":"Wood","year":"2003","journal-title":"Eur J Cancer"},{"key":"10.5604\/01.3001.0010.7531_bib0090","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4251\/wjgo.v2.i11.407","article-title":"Intra-hepatic and extra-hepatic cholangiocarcinoma: New insight into epidemiology and risk factors","volume":"11","author":"Cardinale","year":"2010","journal-title":"World J Gastrointest Oncol"},{"key":"10.5604\/01.3001.0010.7531_bib0095","series-title":"Neoplasms of the Liver","first-page":"3","article-title":"Epidemiology of hepatocellular carcinoma","author":"Mu\u00f1oz","year":"1987"},{"key":"10.5604\/01.3001.0010.7531_bib0100","unstructured":"Muir C, Waterhouse J, Mack T. Cancer Incidence in Five Continents. Vol. 5. Lyon: IARC Publications; 1987, pp. 218-26."},{"key":"10.5604\/01.3001.0010.7531_bib0105","unstructured":"Tabor E, Di Bisceglie AM, Purcell RH. Etiology, Pathology and Treatment of Hepatocellular Carcinoma in America. Houston, TX: Gulf Publishing Co., 1991."},{"key":"10.5604\/01.3001.0010.7531_bib0110","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-2407-2-10","article-title":"Worldwide trends in mortality from biliary tract malignancies","volume":"2","author":"Patel","year":"2002","journal-title":"BMC Cancer"},{"key":"10.5604\/01.3001.0010.7531_bib0115","unstructured":"Howlader N, Noone AM, Krapcho M, Miller D, Bishop K, Kosary CL, Yu M, et al. SEER Cancer Statistics Review, 1975-2014. Bethesda, MD: National Cancer Institute; 2017. Available from: http:\/\/seer.cancer.gov\/csr\/1975_2014\/ [Accesed: November 2017]. Based on November 2016 SEER data submission, posted to the SEER web site, April 2017."},{"key":"10.5604\/01.3001.0010.7531_bib0120","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1055\/s-2006-933562","article-title":"Primary sclerosing cholangitis and cholangiocarcinoma","volume":"1","author":"Lazaridis","year":"2006","journal-title":"Semin Liver Dis"},{"key":"10.5604\/01.3001.0010.7531_bib0125","unstructured":"Yurkiewicz S. PBC patients face high wait-list mortality \u2013 consider allocation of exception MELD points to primary biliary cirrhosis patients on transplant list. New York: MedPage Today; 2015. Available from: https:\/\/ www.medpagetoday.com\/clinical-context\/pbcnash\/51592."},{"key":"10.5604\/01.3001.0010.7531_bib0130","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/bmj.4.5784.408","article-title":"Diagnosis of primary cancer of the liver","volume":"5784","author":"Kew","year":"1971","journal-title":"Br Med J"},{"key":"10.5604\/01.3001.0010.7531_bib0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/13651820801992716","article-title":"Diagnosis of cholangiocarcinoma","volume":"2","author":"Van Beers","year":"2008","journal-title":"HPB? (Oxford)"},{"key":"10.5604\/01.3001.0010.7531_bib0140","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1002\/hep.23294","article-title":"Diagnosis and management of primary sclerosingcolangitis","volume":"2","author":"Chapman","year":"2010","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.7531_bib0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/0300060513505488","article-title":"A review of the clinical diagnosis and therapy of cholangiocarcinoma","volume":"1","author":"Yao","year":"2014","journal-title":"J Int Med Res"},{"key":"10.5604\/01.3001.0010.7531_bib0150","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S2468-1253(17)30296-0","article-title":"Prognostic scores and non-invasive markers in primary sclerosing cholangitis: good for patients or for papers","volume":"11","author":"Thorburn","year":"2017","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0155","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.4254\/wjh.v7.i12.1632","article-title":"Guide for diagnosis and treatment of hepatocellular carcinoma","volume":"12","author":"Attwa","year":"2015","journal-title":"World J Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/1179299X16684640","article-title":"Biomarkers for hepatocellular carcinoma","volume":"9","author":"Lou","year":"2017","journal-title":"Biomark Cancer"},{"key":"10.5604\/01.3001.0010.7531_bib0165","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1021\/acs.jproteome.5b00718","article-title":"Mass-selected site-specific core-fucosylation of serum proteins in hepatocellular carcinoma","volume":"11","author":"Yin","year":"2015","journal-title":"J Proteome Res"},{"key":"10.5604\/01.3001.0010.7531_bib0170","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1158\/1078-0432.CCR-07-0586","article-title":"Serum proteomics and biomarkers in hepatocellular carcinoma and chronic liver disease","volume":"2","author":"Zinkin","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.5604\/01.3001.0010.7531_bib0175","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2217\/bmm-2015-0062","article-title":"Potential diagnostic and prognostic biomarkers for cholangiocarcinoma in serum and bile","volume":"6","author":"Wang","year":"2016","journal-title":"Biomark Med"},{"key":"10.5604\/01.3001.0010.7531_bib0180","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jhep.2011.12.001","article-title":"EASLEORTC clinical practice guidelines: management of hepatocellular carcinoma","volume":"56","year":"2012","journal-title":"J Hepatol"},{"key":"10.5604\/01.3001.0010.7531_bib0185","doi-asserted-by":"crossref","first-page":"e112877","DOI":"10.1371\/journal.pone.0112877","article-title":"PR3-ANCA: a promising biomarker in primary sclerosing cholangitis (PSC)","volume":"11","author":"Stinton","year":"2014","journal-title":"PLoS One"},{"key":"10.5604\/01.3001.0010.7531_bib0190","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/hep.29291","article-title":"Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma","volume":"4","author":"Arbelaiz","year":"2017","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0010.7531_bib0195","first-page":"2667","article-title":"Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles","volume":"16","author":"Gy\u00f6rgy","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"10.5604\/01.3001.0010.7531_bib0200","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm0598-594","article-title":"Eradication of established murine tumors using a novel cell-free vaccine: dendritic cellderived exosomes","volume":"5","author":"Zitvogel","year":"1998","journal-title":"Nat Med"},{"key":"10.5604\/01.3001.0010.7531_bib0205","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1083\/jcb.201211138","article-title":"Extracellular vesicles: exosomes, microvesicles, and friends","volume":"4","author":"Raposo","year":"2013","journal-title":"J Cell Biol"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119301036?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119301036?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:36:36Z","timestamp":1761647796000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268119301036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S1665268119301036"],"URL":"https:\/\/doi.org\/10.5604\/01.3001.0010.7531","relation":{},"ISSN":["1665-2681"],"issn-type":[{"type":"print","value":"1665-2681"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Changing Face of the Diagnosis of Chronic and Malignant Liver Diseases: Potential New Biomarkers","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.5604\/01.3001.0010.7531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.","name":"copyright","label":"Copyright"}]}}