{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:44:18Z","timestamp":1761648258763,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":379,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.5604\/01.3001.0011.7383","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T06:20:52Z","timestamp":1525846852000},"page":"392-402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["A Dynamic Model for Predicting Outcome in Patients with HBV Related Acute-On-Chronic Liver Failure"],"prefix":"10.1016","volume":"17","author":[{"given":"Wei","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongqun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinqiu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenfang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenggang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel S.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongping","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuexin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.5604\/01.3001.0011.7383_bib0005","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0011.7383_bib0010","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12072-008-9106-x","article-title":"Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)","volume":"3","author":"Sarin","year":"2009","journal-title":"Hepatol Int"},{"key":"10.5604\/01.3001.0011.7383_bib0015","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.clinre.2013.05.001","article-title":"Prognostic scores for cirrhotic patients admitted to an intensive care unit: which consequences for liver transplantation","volume":"37","author":"Galbois","year":"2013","journal-title":"Clin Res Hepatol Gastroenterol"},{"key":"10.5604\/01.3001.0011.7383_bib0020","doi-asserted-by":"crossref","first-page":"e0116968","DOI":"10.1371\/journal.pone.0116968","article-title":"Combining serum cystatin C with total bilirubin improves short-term mortality prediction in patients with HBV-related acute-on-chronic liver failure","volume":"28","author":"Wan","year":"2015","journal-title":"PLoS One"},{"key":"10.5604\/01.3001.0011.7383_bib0025","doi-asserted-by":"crossref","first-page":"e54773","DOI":"10.1371\/journal.pone.0054773","article-title":"Effects of nucleoside analogue on patients with chronic hepatitis B-associated liver failure: meta- analysis","volume":"8","author":"Xie","year":"2013","journal-title":"PloS one"},{"key":"10.5604\/01.3001.0011.7383_bib0030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1743-422X-10-134","article-title":"Meta-analysis of the short-term effects of lamivudine treatment for severe chronic hepatitis B","volume":"10","author":"Zhang","year":"2013","journal-title":"Virol J"},{"key":"10.5604\/01.3001.0011.7383_bib0035","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S1665-2681(19)30998-6","article-title":"The efficacy and safety of nucleos(t)ide analogues in the treatment of HBV-related acute-on-chronic liver failure: a meta -analysis","volume":"12","author":"Zhang","year":"2013","journal-title":"Ann Hepatol"},{"key":"10.5604\/01.3001.0011.7383_bib0040","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1053\/jhep.2003.50315","article-title":"The management of ascites in cirrhosis: report on the consensus conference of the International Ascites Club","volume":"38","author":"Moore","year":"2003","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0011.7383_bib0045","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1002\/hep.26359","article-title":"Introduction to the revised American Association for the Study of Liver Diseases Practice Guideline management of adult patients with ascites due to cirrhosis 2012","volume":"57","author":"Runyon","year":"2013","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0011.7383_bib0050","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1053\/jhep.2002.31250","article-title":"Hepatic encephalopathy- Definition, nomenclature, diagnosis, and quantification: Final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998","volume":"35","author":"Ferenci","year":"2002","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0011.7383_bib0055","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1056\/NEJMra031087","article-title":"Hepatitis B virus infection--natural history and clinical consequences","volume":"350","author":"Ganem","year":"2004","journal-title":"N Engl J Med"},{"key":"10.5604\/01.3001.0011.7383_bib0060","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1620\/tjem.155.363","article-title":"Severe acute exacerbation in chronic hepatitis B virus infection in Sendai, Japan","volume":"155","author":"Kanno","year":"1988","journal-title":"Tohoku J Exp Med"},{"key":"10.5604\/01.3001.0011.7383_bib0065","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jhep.2014.02.013","article-title":"Entecavir vs. lamivudine in chronic hepatitis B patients with severe acute exacerbation and hepatic decompensation","volume":"60","author":"Chen","year":"2014","journal-title":"J Hepatol"},{"key":"10.5604\/01.3001.0011.7383_bib0070","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1002\/hep.24109","article-title":"Tenofovir improves the outcome in patients with spontaneous reactivation of hepatitis B presenting as acute-on-chronic liver failure","volume":"53","author":"Garg","year":"2011","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0011.7383_bib0075","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1053\/j.gastro.2011.11.027","article-title":"Granulocyte colony-stimulating factor mobilizes CD34(+) cells and improves survival of patients with acute-on-chronic liver failure","volume":"142","author":"Garg","year":"2012","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0011.7383_bib0080","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.dld.2011.08.029","article-title":"Clinical profile and predictors of mortality in patients of acute-on-chronic liver failure","volume":"44","author":"Garg","year":"2012","journal-title":"Dig Liver Dis"},{"issue":"3","key":"10.5604\/01.3001.0011.7383_bib0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10238-011-0160-7","article-title":"Nucleoside analogues improve the short-term and long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver failure","volume":"12","author":"Chen","year":"2012","journal-title":"Clin Exp Med"},{"issue":"4","key":"10.5604\/01.3001.0011.7383_bib0090","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s12072-012-9344-9","article-title":"Entecavir treatment prevents disease progression in hepatitis B virus-related acute-on-chronic liver failure: Establishment of a novel logistical regression model","volume":"6","author":"Ma","year":"2012","journal-title":"Hepatol Int"},{"issue":"3","key":"10.5604\/01.3001.0011.7383_bib0095","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/j.1440-1746.2009.06089.x","article-title":"Influential factors of prognosis in lamivudine treatment for patients with acute-on-chronic hepatitis B liver failure","volume":"25","author":"Sun","year":"2010","journal-title":"J Gastroenterol Hepatol"},{"key":"10.5604\/01.3001.0011.7383_bib0100","doi-asserted-by":"crossref","first-page":"e19164","DOI":"10.5812\/hepatmon.19164","article-title":"Entecavir Versus Lamivudine therapy for patients with chronic hepatitis B-associated liver failure: a meta-analysis","volume":"14","author":"Zhang","year":"2014","journal-title":"Hepat Mon"},{"key":"10.5604\/01.3001.0011.7383_bib0105","doi-asserted-by":"crossref","first-page":"36","DOI":"10.7150\/ijms.2.36","article-title":"Natural history and clinical consequences of hepatitis B Virus infection","volume":"2","author":"Pan","year":"2005","journal-title":"Int J Med Sci"},{"key":"10.5604\/01.3001.0011.7383_bib0110","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00535-010-0315-4","article-title":"Association of hepatitis B virus mutations in basal core promoter and precore regions with severity of liver disease: an investigation of 793 Chinese patients with mild and severe chronic hepatitis B and acute-on-chronic liver failure","volume":"46","author":"Xu","year":"2011","journal-title":"J Gastroenterol"},{"key":"10.5604\/01.3001.0011.7383_bib0115","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/jmv.22159","article-title":"Hepatitis B virus genotype B with G1896A and A1762T\/ G1764A mutations is associated with hepatitis B related acute-on-chronic liver failure","volume":"83","author":"Xiao","year":"2011","journal-title":"J Med Virol"},{"key":"10.5604\/01.3001.0011.7383_bib0120","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/j.1365-2893.2009.01254.x","article-title":"Hepatitis B virus genotype and basal core promoter\/precore mutations are associated with hepatitis B-related acute-on-chronic liver failure without pre-existing liver cirrhosis","volume":"17","author":"Ren","year":"2010","journal-title":"J Viral Hepat"},{"key":"10.5604\/01.3001.0011.7383_bib0125","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.cgh.2010.12.027","article-title":"A model to determine 3-month mortality risk in patients with acute-on-chronic hepatitis B liver failure","volume":"9","author":"Zheng","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.5604\/01.3001.0011.7383_bib0130","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/j.1365-2893.2008.01046.x","article-title":"Prediction of the prognosis of patients with acuteon-chronic hepatitis B liver failure using the model for endstage liver disease scoring system and a novel logistic regression model","volume":"16","author":"Sun","year":"2009","journal-title":"J Viral Hepat"},{"key":"10.5604\/01.3001.0011.7383_bib0135","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1872-034X.2011.00902.x","article-title":"Novel scoring system as a useful model to predict the outcome of patients with acute liver failure: Application to indication criteria for liver transplantation","volume":"42","author":"Naiki","year":"2012","journal-title":"Hepatol Res"},{"key":"10.5604\/01.3001.0011.7383_bib0140","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.cgh.2015.09.029","article-title":"Acute Liver Failure Study Group. Thrombocytopenia is associated with multi-organ system failure in patients with acute liver failure","volume":"14","author":"Stravitz","year":"2016","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.5604\/01.3001.0011.7383_bib0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpg.2012.01.014","article-title":"Recent developments in acute liver failure","volume":"26","author":"Lee","year":"2012","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.5604\/01.3001.0011.7383_bib0150","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1123842","article-title":"Platelet-derived serotonin mediates liver regeneration","volume":"312","author":"Lesurtel","year":"2006","journal-title":"Science"},{"key":"10.5604\/01.3001.0011.7383_bib0155","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/hep.26372","article-title":"An unbalance between von Willebrand factor and ADAMTS13 in acute liver failure: Implications for hemostasis and clinical outcome","volume":"58","author":"Hugenholtz","year":"2013","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0011.7383_bib0160","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3350\/cmh.2015.21.3.232","article-title":"Static and dynamic prognostic factors for hepatitis-B-related acute-on-chronic liver failure","volume":"21","author":"Ha","year":"2015","journal-title":"Clin Mol Hepatol"},{"key":"10.5604\/01.3001.0011.7383_bib0165","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.jhep.2005.01.019","article-title":"Evaluation of the increase in model for end-stage liver disease (Delta MELD) score over time as a prognostic predictor in patients with advanced cirrhosis: risk factor analysis and comparison with initial MELD and Child-Turcotte-Pugh score","volume":"42","author":"Huo","year":"2005","journal-title":"J Hepatol"},{"key":"10.5604\/01.3001.0011.7383_bib0170","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4240\/wjgs.v4.i12.281","article-title":"Incorporating dynamics for predicting poor outcome in acute liver failure patients","volume":"4","author":"Chamuleau","year":"2012","journal-title":"World J Gastrointest Surg"},{"key":"10.5604\/01.3001.0011.7383_bib0175","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/hep.27849","article-title":"Clinical course of acute-on-chronic liver failure syndrome and effects on prognosis","volume":"62","author":"Gustot","year":"2015","journal-title":"Hepatology"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119301942?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119301942?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:37:21Z","timestamp":1761647841000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268119301942"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S1665268119301942"],"URL":"https:\/\/doi.org\/10.5604\/01.3001.0011.7383","relation":{},"ISSN":["1665-2681"],"issn-type":[{"type":"print","value":"1665-2681"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Dynamic Model for Predicting Outcome in Patients with HBV Related Acute-On-Chronic Liver Failure","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.5604\/01.3001.0011.7383","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2018 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.","name":"copyright","label":"Copyright"}]}}