{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T05:20:52Z","timestamp":1648790452046},"reference-count":0,"publisher":"Index Copernicus","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol Przegl Chir"],"published-print":{"date-parts":[[2018,6,20]]},"abstract":"<jats:p>Abstract\nPurpose: The aim of the study was to determine of carcinoembryonal antigen and matrix metalloproteinase 2 peritoneal washes and serum concentration in patients suffering from colorectal cancer concerning tumor staging and 5-year survival rate in these patients.\nMethods: 80 patients who underwent curative surgery for colorectal cancer were included into the study. Preoperative serum and intraoperative peritoneal washes CEA and MMP-2 concentrations were measured. \nResults: Concerning tumor penetration CEA-s and CEA-p concentration was higher in subsequent stages from T2 to T4. Both CEA-s and CEA-p concentration was lower in T2 comparing to T3 and T4. Significant difference of CEA-s and CEA-p was noted between T2 and T4 stages. MMP2-s concentration was higher in T3 comparing to T2, the highest MMP2-p concentration was in T4, with no statistical significance. Concerning nodular status significant difference of CEA-s was noted between N0 and N1. For CEA-p significance was found between N0 and N2 as between N1 and N2. MMP2-s concentration was the highest in N1, MMP2-p concentration was the highest in T4, with no statistical significance.\n5-year survival rate for all patients was 63,53%. There were significant differences in CEA-s and CEA-p concentration between patients with negative and positive 5-year survival. \nConclusion: Intraoperative peritoneal washes concentration of CEA may potentially serve as an important factor for more precise colorectal cancer staging. CEA-p and CEA-s concentration correlates with survival rate in patients suffering from colorectal cancer and can be useful as an additional  prognostic factor. Usefulness of MMP2 measurement still requires further studies.\n\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0012.1269","type":"journal-article","created":{"date-parts":[[2018,7,2]],"date-time":"2018-07-02T18:09:45Z","timestamp":1530554985000},"page":"36-43","source":"Crossref","is-referenced-by-count":1,"title":["Carcinoembryonic  antigen and matrix metalloproteinase 2 serum and peritoneal washes concentration in staging and prognosis in colorectal cancer patients"],"prefix":"10.5604","volume":"90","author":[{"given":"Tomasz","family":"Guzel","sequence":"first","affiliation":[{"name":"Warszawski Uniwersytet Medyczny Wydzia\u0142 I Lekarski Katedra i Klinika Chirurgii Og\u00f3lnej, Gastroenterologicznej i Onkologicznej WUM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dagmara","family":"Mirowska-Guzel","sequence":"additional","affiliation":[{"name":"Warszawski Uniwersytet Medyczny  Katedra i Zak\u0142\u0105d Farmakologii Do\u015bwiadczalnej i Klinicznej"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaw","family":"Lech","sequence":"additional","affiliation":[{"name":"Warszawski Uniwersytet Medyczny Wydzia\u0142 I Lekarski Katedra i Klinika Chirurgii Og\u00f3lnej, Gastroenterologicznej i Onkologicznej WUM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Wro\u0144ski","sequence":"additional","affiliation":[{"name":"Warszawski Uniwersytet Medyczny"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena","family":"Iwanowska","sequence":"additional","affiliation":[{"name":"Warszawski Uniwersytet Medyczny Wydzia\u0142 Nauki o Zdrowiu Laboratorium Centralne SP CSK WUM"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maciej","family":"S\u0142odkowski","sequence":"additional","affiliation":[{"name":"Warszawski Uniwersytet Medyczny Wydzia\u0142 I Lekarski Katedra i Klinika Chirurgii Og\u00f3lnej, Gastroenterologicznej i Onkologicznej WUM"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3689","container-title":["Polish Journal of Surgery"],"original-title":[],"link":[{"URL":"https:\/\/ppch.pl\/gicid\/pdf\/01.3001.0012.1269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ppch.pl\/gicid\/pdf\/01.3001.0012.1269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T12:08:38Z","timestamp":1542197318000},"score":1,"resource":{"primary":{"URL":"https:\/\/ppch.pl\/gicid\/01.3001.0012.1269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,20]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,6,20]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0012.1269","relation":{},"ISSN":["0032-373X","2299-2847"],"issn-type":[{"value":"0032-373X","type":"print"},{"value":"2299-2847","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,20]]}}}