{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:28:20Z","timestamp":1774326500467,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"vor","delay-in-days":137,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.5604\/01.3001.0012.7906","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T06:12:02Z","timestamp":1544767922000},"page":"144-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Metabolomics Discloses a New Non-invasive Method for the Diagnosis and Prognosis of Patients with Alcoholic Hepatitis"],"prefix":"10.1016","volume":"18","author":[{"given":"Javier","family":"Michelena","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibon","family":"Mart\u00ednez-Arranz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Altamirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca","family":"Mayo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Sancho-Bru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ram\u00f3n","family":"Bataller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pere","family":"Gin\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azucena","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Caballer\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.5604\/01.3001.0012.7906_bib0010","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1111\/j.1572-0241.2006.01034.x","article-title":"Spectrum of liver histology in presumed decompensated alcoholic liver disease.","volume":"102","author":"Elphick","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"10.5604\/01.3001.0012.7906_bib0015","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1056\/NEJMra0805786","article-title":"Alcoholic Hepatitis.","volume":"360","author":"Lucey","year":"2009","journal-title":"N Engl J Med"},{"key":"10.5604\/01.3001.0012.7906_bib0020","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jhep.2012.04.004","article-title":"EASL clinical practice guidelines: management of alcoholic liver disease.","volume":"57","year":"2012","journal-title":"J Hepatol"},{"key":"10.5604\/01.3001.0012.7906_bib0025","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00004836-200405000-00012","article-title":"The role of the discriminant factor in the assessment and treatment of alcoholic hepatitis.","volume":"38","author":"Kulkarni","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"10.5604\/01.3001.0012.7906_bib0030","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0016-5085(78)90401-8","article-title":"Corticosteroid therapy of alcoholic hepatitis.","volume":"75","author":"Maddrey","year":"1978","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0012.7906_bib0035","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/hep.20503","article-title":"MELD accurately predicts mortality in patients with alcoholic hepatitis.","volume":"41","author":"Dunn","year":"2005","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0012.7906_bib0040","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1136\/gut.2004.050781","article-title":"Analysis of factors predictive of mortality in alcoholic hepatitis and derivation and validation of the Glasgow alcoholic hepatitis score.","volume":"54","author":"Forrest","year":"2005","journal-title":"Gut"},{"key":"10.5604\/01.3001.0012.7906_bib0045","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1111\/j.1572-0241.2008.02104.x","article-title":"A new scoring system for prognostic stratification of patients with alcoholic hepatitis.","volume":"103","author":"Dominguez","year":"2008","journal-title":"Am J Gastroenterol"},{"key":"10.5604\/01.3001.0012.7906_bib0050","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1053\/j.gastro.2014.01.018","article-title":"A histologic scoring system for prognosis of patients with alcoholic hepatitis.","volume":"146","author":"Altamirano","year":"2014","journal-title":"Gastroenterology"},{"key":"10.5604\/01.3001.0012.7906_bib0055","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2011.01.031","article-title":"Serum metabolomics reveals gamma-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease.","volume":"55","author":"Soga","year":"2011","journal-title":"J Hepatol"},{"key":"10.5604\/01.3001.0012.7906_bib0060","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/ajg.2013.11","article-title":"Metabolomics discloses potential biomarkers for the noninvasive diagnosis of idiopathic portal hypertension.","volume":"108","author":"Seijo","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"4","key":"10.5604\/01.3001.0012.7906_bib0065","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1021\/pr201223p","article-title":"Obesity dependent metabolic signatures associated with nonalcoholic fatty liver disease progression.","volume":"11","author":"Barr","year":"2012","journal-title":"J Proteome Res"},{"key":"10.5604\/01.3001.0012.7906_bib0070","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/hep.21607","article-title":"The Lille model: a new tool for therapeutic strategy in patients with severe alcoholic hepatitis treated with steroids.","volume":"45","author":"Louvet","year":"2007","journal-title":"Hepatology"},{"key":"10.5604\/01.3001.0012.7906_bib0075","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jprot.2015.01.019","article-title":"Enhancing metabolomics research through data mining.","volume":"127","author":"Martinez-Arranz","year":"2015","journal-title":"J Proteomics"},{"key":"10.5604\/01.3001.0012.7906_bib0080","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.cgh.2013.08.048","article-title":"The breathprints in patients with liver disease identify novel breath biomarkers in alcoholic hepatitis.","volume":"12","author":"Hanouneh","year":"2014","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.5604\/01.3001.0012.7906_bib0085","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.cmet.2014.01.002","article-title":"Peroxisomes: a nexus for lipid metabolism and cellular signaling.","volume":"19","author":"Lodhi","year":"2014","journal-title":"Cell Metab"},{"key":"10.5604\/01.3001.0012.7906_bib0090","first-page":"115","article-title":"Fatty acid regulation of hepatic lipid metabolism.","volume":"14","author":"Jump","year":"2011","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.5604\/01.3001.0012.7906_bib0095","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/0005-2760(90)90141-J","article-title":"Lipoproteins secreted by cultured rat hepato-cytes contain the antioxidant 1-alk-1-enyl-2-acylglycero-phosphoethanolamine.","volume":"1045","author":"Vance","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.5604\/01.3001.0012.7906_bib0100","doi-asserted-by":"crossref","first-page":"e113860","DOI":"10.1371\/journal.pone.0113860","article-title":"Serum metabolomic profiling in acute alcoholic hepatitis identifies multiple dysregulated pathways.","volume":"9","author":"Rachakonda","year":"2014","journal-title":"PloS ONE"},{"key":"10.5604\/01.3001.0012.7906_bib0105","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.jhep.2016.01.003","article-title":"Multivariate metabotyping of plasma predicts survival in patients with decompensated cirrhosis.","volume":"64","author":"McPhail","year":"2016","journal-title":"J Hepatol"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119303163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119303163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:40:01Z","timestamp":1761648001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268119303163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S1665268119303163"],"URL":"https:\/\/doi.org\/10.5604\/01.3001.0012.7906","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomics Discloses a New Non-invasive Method for the Diagnosis and Prognosis of Patients with Alcoholic Hepatitis","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.5604\/01.3001.0012.7906","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2019 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.","name":"copyright","label":"Copyright"}]}}