{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:02:31Z","timestamp":1648760551389},"reference-count":0,"publisher":"Index Copernicus","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>Background. Osteoarthritis is an incurable, progressive, degenerative and debilitating joint disease, characterized by pain, stiffness and limitation of joint mobility. Treatment is limited to symptom management and includes pharmaco- and physiotherapy, rehabilitation and surgery.\nObjective. To evaluate safety and effectiveness of a selected hyaluronic acid injectable in the treatment of small joint osteoarthritis.\nMaterials and methods. 324 patients (F: 190, M: 134) aged 19-84 completed the study. Each participant received three, weekly intra-articular hyaluronic acid injections (Suplasyn\u00ae, Bioniche Life Sciences Inc, Belleville, Ontario; 700 kDa, 7 ml\/7 mg). Morning stiffness and pain intensity (at rest and movement-induced) before and after treatment as well as post-treatment improvement in joint mobility were assessed based on questionnaires filled out by patients and their physicians prior to treatment commencement and at its conclusion. Participants used a Numerical Rating Scale (range 0-10 points) to quantify assessments. Data was analysed with chi-square and Fisher\u2019s exact tests and p = 0.05 was accepted as significant.\nResults. A significant (p &lt;0.001) post-treatment reduction in (1) morning stiffness (median NRS score decrease from 6 to 2 points), (2) pain intensity at rest (median NRS score decrease from 5 to 2 points) and movement induced (median NRS value decrease from 6 to 2 points). Improvement in joint mobility was reported by 97% of patients. Treatment tolerability (safety) was assessed as good to excellent by 25 % and 74% of patients, respectively. No serious adverse reactions were reported.\nConclusion. Hyaluronic acid injections are a highly effective and safe treatment for symptomatic small joint osteoarthritis.\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0012.8391","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:36:20Z","timestamp":1547004980000},"page":"437-443","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the Effectiveness of Hyaluronic Acid Injections in Treatment of Small Joint Osteoarthritis"],"prefix":"10.5604","volume":"20","author":[{"given":"Ma\u0142gorzata","family":"Mi\u0119dzyb\u0142ocka","sequence":"first","affiliation":[{"name":"University and Hospital Department of Traumatology, Orthopaedics and Hand Surgery, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Czarnecki","sequence":"additional","affiliation":[{"name":"University and Hospital Department of Traumatology, Orthopaedics and Hand Surgery, Poznan University of Medical Sciences, Poznan, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3689","container-title":["Ortopedia Traumatologia Rehabilitacja"],"original-title":[],"deposited":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T03:36:20Z","timestamp":1547004980000},"score":1,"resource":{"primary":{"URL":"https:\/\/ortopedia.com.pl\/gicid\/01.3001.0012.8391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,31]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10,31]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0012.8391","relation":{},"ISSN":["1509-3492","2084-4336"],"issn-type":[{"value":"1509-3492","type":"print"},{"value":"2084-4336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,31]]}}}