{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:01:38Z","timestamp":1784757698690,"version":"3.55.0"},"reference-count":0,"publisher":"Index Copernicus","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol Przegl Chir"],"published-print":{"date-parts":[[2019,2,7]]},"abstract":"<jats:p>Introduction: Endocrine and metabolic paraneoplastic syndromes in the course of malignant tumours result from ectopic production of hormones or hormone precursors in tumour cells. Production of hormones by endocrine tumours is relatively frequent, while such production by adenocarcinoma cells is definitely rare. The study presents a case of triple negative invasive breast cancer, with ectopic secretion of ACTH (Adrenocorticotropic hormone), which provokes serious metabolic disorders.\n\nMaterials and methods: The patient was admitted to hospital with symptoms of Cushing`s syndrome. Diagnostic tests revealed that a cause of metabolic disorders was breast cancer. After proper preparation the patient was qualified for surgery.\n\nResults: After mastectomy the patient\u2019s metabolism stabilised. The patient underwent adjuvant chemotherapy and radiotheraphy. 4 months after the last cycle of systemic treatment, cancer dissemination was found. The patient was treated with second-line chemotherapy, however control CT revealed progression. The patient died 20 months after surgery and two months after the last cycle of chemotherapy.\n\nConclusions: The case reported in this study \u2013 triple negative invasive breast cancer, responsible for ectopic production of ACTH and causing Cushing\u2019s syndrome \u2013 is a rare phenomenon. Treatment of patients with breast cancer showing hormonal activity should not differ from general rules applied for breast cancer. However due to accompanying metabolic disturbances, the patients need individualised oncological approach, precise diagnostic tests and adequate preoperative preparation. \n\n\n\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0012.8684","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T14:57:51Z","timestamp":1554994671000},"page":"45-47","source":"Crossref","is-referenced-by-count":1,"title":["Triple negative breast cancer with ACTH-dependent Cushing's syndrome - case report"],"prefix":"10.5604","volume":"91","author":[{"given":"Diana","family":"Hodorowicz-Zaniewska","sequence":"first","affiliation":[{"name":"Uniwersytet Jagiello\u0144ski Collegium Medicum Wydzia\u0142 Lekarski I Katedra Chirurgii Og\u00f3lnej"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Brzuszkiewicz","sequence":"additional","affiliation":[{"name":"Uniwersytet Jagiello\u0144ski Collegium Medicum Wydzia\u0142 Lekarski I Katedra Chirurgii Og\u00f3lnej"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Szpor","sequence":"additional","affiliation":[{"name":"Uniwersytet Jagiello\u0144ski Collegium Medicum Wydzia\u0142 Lekarski Katedra Patomorfologii"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","container-title":["Polish Journal of Surgery"],"original-title":[],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T14:57:56Z","timestamp":1554994676000},"score":1,"resource":{"primary":{"URL":"https:\/\/ppch.pl\/gicid\/01.3001.0012.8684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,7]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0012.8684","relation":{},"ISSN":["0032-373X","2299-2847"],"issn-type":[{"value":"0032-373X","type":"print"},{"value":"2299-2847","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]}}}