{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:36:46Z","timestamp":1790624206154,"version":"4.1.0"},"reference-count":0,"publisher":"Index Copernicus","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol Przegl Chir"],"published-print":{"date-parts":[[2019,6,10]]},"abstract":"<jats:p>Abstract\nTreatment of perianal fistulizing Crohn\u2019s disease is demanding and burdened with a high percentage of failures, which forces clinicians to search for new, more effective therapeutic options. One of these options is the use of adipose-derived mesenchymal stem cells in local administration. Due to their multipotentiality and complex mechanism of action, stem cells are the promising new therapeutic approach for the treatment-refractory complex perianal fistulas - demonstrating both high efficacy and a favorable safety profile.\nThe paper presents current knowledge on the mechanisms of action and manner of administration of mesenchymal stem cells, as well as the effectiveness and safety of their use in the treatment of perianal Crohn's disease based on available literature.\n\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0013.2390","type":"journal-article","created":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T07:52:20Z","timestamp":1561708340000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Mesenchymal stem cells for the treatment of complex perianal fistulas in patients with Crohn disease"],"prefix":"10.5604","volume":"91","author":[{"given":"Katarzyna","family":"Borycka-Kiciak","sequence":"first","affiliation":[{"name":"Department of General and Gastrointestinal Surgery, Orlowski Hospital,    Centre of Postgraduate Medical Education, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pietrzak","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Clinical Oncology, Centre of Postgraduate Medical Education, Warsaw, Poland; Department of Oncological Gastroenterology Institute of Oncology, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Kielar","sequence":"additional","affiliation":[{"name":"Department of Oncology and Nursing Oncology, Institute of Nursing and Obstetrics, Faculty  of Medicine and Health Sciences, Jan Kochanowski University, Kielce, Poland; Department of General Surgery, Medicover Hospital, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw","family":"Tarnowski","sequence":"additional","affiliation":[{"name":"Department of General and Gastrointestinal Surgery, Orlowski Hospital,    Centre of Postgraduate Medical Education, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","container-title":["Polish Journal of Surgery"],"original-title":[],"deposited":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T07:52:23Z","timestamp":1561708343000},"score":1,"resource":{"primary":{"URL":"https:\/\/ppch.pl\/gicid\/01.3001.0013.2390"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,10]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6,16]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0013.2390","relation":{},"ISSN":["0032-373X","2299-2847"],"issn-type":[{"value":"0032-373X","type":"print"},{"value":"2299-2847","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,10]]}}}