{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T19:06:44Z","timestamp":1784315204422,"version":"3.55.0"},"reference-count":0,"publisher":"Index Copernicus","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol Przegl Chir"],"published-print":{"date-parts":[[2020,4,16]]},"abstract":"<jats:p>Background:\nPancreatic cancer is a devastating disease, being the fourth cause of cancer-related death worldwide.\nSeveral studies have investigated the use of multiple cancer biomarkers, such as C\u00a019-9, CA\u00a0125, and CEA, as prognostic factors for overall survival in pancreatic cancer. CA\u00a0125 seems to have superior predictive utility in selected groups of PDAC patients.\n\nMaterial and methods:\nWe retrospectively analyzed data collected from 129 patients admitted to our Department due to diagnosis with pancreatic cancer. Prior to the survival analysis, the preliminary assessment of pre-treatment levels of biomarkers was carried out. The overall survival time was defined as that elapsing from the admission date to the date of death. \n\nResults:\nThe patients mean age was 62 +\/- 9.5 years, while the median overall survival (OS) was 7mo 12d. As for tumor localization, most of the patients had PDAC within the head of the pancreas (n=93), followed by PDAC of the pancreatic body (n=15), pancreatic tail (n=14) and both pancreatic body and tail (n=7). Ninety-five patients had an unresectable tumor and 34 were diagnosed with a resectable tumor (tab.1). \nThe statistically significant correlation was found for CA\u00a0125 (\u03c1=-0.355 p&lt;0.001) and CA\u00a019-9 (\u03c1=-0.225 p=0.012). We chose the following cut-off points: CA\u00a0125&gt;=20 IU\/mL was considered as high, and CA\u00a019-9&gt;=200 IU\/mL as significantly elevated. In the univariate analysis in the Kaplan-Meier survival model, adjusted for age, both elevated biomarkers were statistically significant prognostic factors of OS (CA\u00a0125&lt;20 median OS- 10mo 3d vs. CA\u00a0125&gt;=20- 4mo 17d p=0.001) and (CA19-9&lt;200 median OS- 8mo 3d vs. CA\u00a019-9&gt;=200- 4mo 20d p=0.001). Patients\u2019 gender and, PDAC resectability and its localization were not statistically significant prognostic factors (log rank test p=0.8; p=0.108 and p=0.578 respectively). In the age-adjusted multivariate analysis, both biomarkers remained significant- CA\u00a0125&gt;=20 (HR: 1.73 95%CI 1.27-2.58 p=0.006) CA\u00a019-9&gt;=200 (HR: 1.78 95%CI 1.19-2.66 p=0.005)\n\nConclusions:\nOur study proves the utility of the pretreatment assessment of CA\u00a0125 because its level is tightly correlated with OS. It may be hypothesized that the pretreatment measurement of both CA\u00a019-9 and CA\u00a0125 can provide the valuable information about patients\u2019 prognosis.\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0014.0950","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T10:20:23Z","timestamp":1587378023000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Elevated preoperative levels of CA\u00a019-9 and CA\u00a0125 predicts overall survival time in\u00a0the pancreatic adenocarcinoma. Single institution series."],"prefix":"10.5604","volume":"92","author":[{"given":"Piotr","family":"Hogendorf","sequence":"first","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Skulimowski","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Durczy\u0144ski","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Kumor","sequence":"additional","affiliation":[{"name":"Klinika Pneumonologii i Alergologii, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u017cyna","family":"Pozna\u0144ska","sequence":"additional","affiliation":[{"name":"Klinika Anestezjologii i Intensywnej Terapii, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Pozna\u0144ska","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Ole\u015bna","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Rut","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siri","family":"\u00d8vereng Julieb\u00f8","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneta","family":"Szmiel","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Strzelczyk","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii Og\u00f3lnej i Transplantacyjnej, Uniwersytet Medyczny w \u0141odzi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","container-title":["Polish Journal of Surgery"],"original-title":[],"deposited":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T10:20:26Z","timestamp":1587378026000},"score":1,"resource":{"primary":{"URL":"https:\/\/ppch.pl\/gicid\/01.3001.0014.0950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,16]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,4,16]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0014.0950","relation":{},"ISSN":["0032-373X","2299-2847"],"issn-type":[{"value":"0032-373X","type":"print"},{"value":"2299-2847","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,16]]}}}