{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:23:29Z","timestamp":1793255009717,"version":"4.5.0"},"reference-count":0,"publisher":"Index Copernicus","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,30]]},"abstract":"<jats:p>Bone tissue actively contributes to the regulation of systemic homoeostasis, and particularly the maintenance of calcium-phosphate balance. The parathyroid hormone-vitamin D feedback axis is balanced by the recently discovered bone-FGF23-kidney hormonal axis. An active complex consisting of FGF23, a receptor and Klotho protein blocks phosphate reabsorption in the proximal tubules, increasing urine phosphate levels and decreasing blood phosphate levels. Mutations of the gene mediating FGF23 transcription lead to a number of diseases, examples including autosomal dominant hypophosphataemic rickets. Klotho protein is a cofactor for FGF23 displaying cardio-, vaso- and nephroprotective activity. It increases calcium reabsorption in the kidneys and inhibits phosphate reabsorption. It also exerts antioxidative and anti-insulin effects and inhibits tissue calcification and apoptosis. As an inhibitor of bone resorption, osteoprotegerin becomes an important contributor to bone remodelling, while RANK\/RANKL signalling inhibition is used in the treatment of postmenopausal osteoporosis. Osteocalcin plays an important role in energy metabolism in the human body. Sclerostin exerts \na strong catabolic effect on bone tissue. Newly identified contributors to the regulation of calcium and phosphate homoeostasis suggest that bone tissue plays a complex role in the systemic metabolism.\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0014.1153","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T12:42:05Z","timestamp":1588855325000},"page":"69-76","source":"Crossref","is-referenced-by-count":6,"title":["Contribution of Bone Tissue to Regulation of Calcium and Phosphate Metabolism. Role of FGF23 and Klotho Protein"],"prefix":"10.5604","volume":"22","author":[{"given":"Maciej","family":"Brz\u0119czek","sequence":"first","affiliation":[{"name":"Oddzia\u0142 Chirurgii Urazowo-Ortopedycznej, Zesp\u00f3\u0142 Opieki Zdrowotnej w Ole\u015bnie, Polska \/  Department of Trauma and Orthopaedic Surgery, Health Care Facility in Ole\u015bno, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Hyla-Klekot","sequence":"additional","affiliation":[{"name":"Klinika Chirurgii i Urologii Dzieci\u0119cej, \u015al\u0105ski Uniwersytet Medyczny w Katowicach, Polska  \/ Department of Paediatric Surgery and Urology, Medical University of Silesia in Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciszek","family":"Kokot","sequence":"additional","affiliation":[{"name":"Klinika Nefrologii, Transplantologii i Chor\u00f3b Wewn\u0119trznych, \u015al\u0105ski Uniwersytet Medyczny w Katowicach, Polska \/ Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia in Katowice, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marek","family":"Synder","sequence":"additional","affiliation":[{"name":"Klinika Ortopedii z Pododdzia\u0142em Ortopedii Dzieci\u0119cej, Centralny Szpital Kliniczny Uniwersytetu Medycznego w \u0141odzi, Polska \/ Department of Orthopaedics with Paediatric Orthopaedics Ward, Central Teaching Hospital of the Medical University of Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","container-title":["Ortopedia Traumatologia Rehabilitacja"],"original-title":[],"deposited":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T12:42:08Z","timestamp":1588855328000},"score":1,"resource":{"primary":{"URL":"https:\/\/ortopedia.com.pl\/gicid\/01.3001.0014.1153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,30]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,4,30]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0014.1153","relation":{},"ISSN":["1509-3492","2084-4336"],"issn-type":[{"value":"1509-3492","type":"print"},{"value":"2084-4336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,30]]}}}