{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:13:35Z","timestamp":1785248015261,"version":"3.55.0"},"reference-count":53,"publisher":"Index Copernicus","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol Pol"],"published-print":{"date-parts":[[2020,12,29]]},"abstract":"<jats:p>M\u00e9ni\u00e8re\u2019s disease is characterized by sudden episodes of vertigo accompanied by tinnitus and\/or feeling of fullness in the ear as well as fluctuating sensorineural hearing loss. Despite numerous studies, the etiology of this disease remains unknown. However, the enlargement of the inner ear\u2019s endolymphatic spaces, referred to as endolymphatic hydrops, is considered the underlying condition. Thanks to recent advances in magnetic resonance (MR) technology, it is now possible to obtain in vivo imaging of endolymphatic hydrops in patients presenting with M\u00e9ni\u00e8re\u2019s disease symptoms. Visualization of the inner ear fluid compartments is achieved after gadolinium contrast is administered into the tympanic cavity or via the intravenous route. Evaluation of endolymphatic hydrops is possible as the contrast agent selectively penetrates the perilymph, and endolymph is visualized as contrast defects. The currently used radiological hydrops grading systems include qualitative, semi-quantitative, and volumetric scales. The methods are subject to ongoing modifications to increase their sensitivity and specificity. Numerous studies describe correlations between clinical symptoms and audiological and otoneurological examination results with the endolymphatic hydrops grade. MRI is also applicable in patients\u2019 diagnostics with an incomplete or atypical course of the M\u00e9ni\u00e8re\u2019s disease. In the course of the treatment, follow-up MRI scans enable assessing individual treatment modalities\u2019 efficacy in terms of the severity of lesions and the further course of the disease within the inner ear.\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0014.6176","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T12:37:14Z","timestamp":1619008634000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Magnetic resonance imaging of the inner ear in the diagnostics of M\u00e9ni\u00e8re\u2019s disease"],"prefix":"10.5604","volume":"75","author":[{"given":"Agnieszka","family":"Jasi\u0144ska","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland; Head: Prof. Kazimierz Niemczyk MD PhD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Lachowska","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland; Head: Prof. Kazimierz Niemczyk MD PhD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Wnuk","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, Medical University of Warsaw, Poland; Head: Prof. Olgierd Rowi\u0144ski MD PhD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazimierz","family":"Niemczyk","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Warsaw, Poland; Head: Prof. Kazimierz Niemczyk MD PhD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","reference":[{"key":"210929r1","doi-asserted-by":"crossref","unstructured":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meni\u00e8re\u2019s disease. American Academy of Otolaryngology- Head and Neck Foundation, Inc. Otolaryngol-Head Neck Surg., 1995; 113(3): 181\u2013185.","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"210929r2","doi-asserted-by":"crossref","unstructured":"Goebel J.A.: 2015 Equilibrium Committee Amendment to the 1995 AAO- -HNS Guidelines for the Definition of Meniere\u2019s Disease. Otolaryngol Head Neck Surg., 2016; 154(3): 403\u2013404.","DOI":"10.1177\/0194599816628524"},{"key":"210929r3","doi-asserted-by":"crossref","unstructured":"Basura G.J., Adams M.E., Monfared A. et al.: Clinical Practice Guideline: Meniere\u2019s Disease. Otolaryngol Head Neck Surg., 2020; 162(2_suppl): S1-S55.","DOI":"10.1177\/0194599820909438"},{"key":"210929r4","doi-asserted-by":"crossref","unstructured":"Sajjadi H., Paparella M.M.: Meniere\u2019s disease. Lancet., 2008; 372(9636): 406\u2013414.","DOI":"10.1016\/S0140-6736(08)61161-7"},{"key":"210929r5","doi-asserted-by":"crossref","unstructured":"Paparella M.M., Djalilian H.R.: Etiology, pathophysiology of symptoms, and pathogenesis of Meniere\u2019s disease. Otolaryngol Clin North Am., 2002; 35(3): 529\u2013545, vi.","DOI":"10.1016\/S0030-6665(02)00019-1"},{"key":"210929r6","doi-asserted-by":"crossref","unstructured":"Noij K.S., Herrmann B.S., Guinan J.J., Jr., Rauch S.D.: Predicting Development of Bilateral Meniere\u2019s Disease Based on cVEMP Threshold and Tuning. Otol Neurotol., 2019; 40(10): 1346\u20131352.","DOI":"10.1097\/MAO.0000000000002375"},{"key":"210929r7","doi-asserted-by":"crossref","unstructured":"Suh M.J., Jeong J., Kim H.J., Jung J., Kim S.H.: Clinical Characteristics of Bilateral Meniere\u2019s Disease in a Single Asian Ethnic Group. Laryngoscope., 2019; 129(5): 1191\u20131196.","DOI":"10.1002\/lary.27423"},{"key":"210929r8","doi-asserted-by":"crossref","unstructured":"Huang C.H., Young Y.H.: Bilateral Meniere\u2019s disease assessed by an inner ear test battery. Acta Otolaryngol., 2015; 135(3): 233\u2013238.","DOI":"10.3109\/00016489.2014.962184"},{"key":"210929r9","doi-asserted-by":"crossref","unstructured":"Frejo L., Soto-Varela A., Santos-Perez S. et al.: Clinical Subgroups in Bilateral Meniere Disease. Front Neurol., 2016; 7: 182.","DOI":"10.3389\/fneur.2016.00182"},{"key":"210929r10","doi-asserted-by":"crossref","unstructured":"Gurkov R., Pyyko I., Zou J., Kentala E.: What is Meniere\u2019s disease? A contemporary re-evaluation of endolymphatic hydrops. J Neurol., 2016; 263(Suppl 1): S71\u201381.","DOI":"10.1007\/s00415-015-7930-1"},{"key":"210929r11","doi-asserted-by":"crossref","unstructured":"Weinreich H.M., Agrawal Y.: The link between allergy and Meniere\u2019s disease. Curr Opin Otolaryngol Head Neck Surg., 2014; 22(3): 227\u2013230.","DOI":"10.1097\/MOO.0000000000000041"},{"key":"210929r12","doi-asserted-by":"crossref","unstructured":"Greco A., Gallo A., Fusconi M. et al.: Meniere\u2019s disease might be an autoimmune condition? Autoimmun Rev., 2012; 11(10): 731\u2013738.","DOI":"10.1016\/j.autrev.2012.01.004"},{"key":"210929r13","doi-asserted-by":"crossref","unstructured":"Requena T., Cabrera S., Martin-Sierra C. et al.: Identification of two novel mutations in FAM136A and DTNA genes in autosomal-dominant familial Meniere\u2019s disease. Hum Mol Genet., 2015; 24(4): 1119\u20131126.","DOI":"10.1093\/hmg\/ddu524"},{"key":"210929r14","unstructured":"M\u00e9ni\u00e9re P.: Sur une forme de surdit\u00e9 grave d\u00e9pendant d\u2019une l\u00e9sion de l\u2019oreille interne. Gaz Med Paris., 1861; 16: 239\u2013240."},{"key":"210929r15","doi-asserted-by":"crossref","unstructured":"Hallpike C.S., Cairns H.: Observations on the pathology of Meniere\u2019s syndrome. Proc R Soc Med., 1938; 31: 1317\u20131336.","DOI":"10.1177\/003591573803101112"},{"key":"210929r16","unstructured":"Yamakawa K.: \u00dcber pathologische Ver\u00e4nderungen bei einem Meni\u00e8re Kranken. Otolaryngl Soc Jap., 1938; 4: 2310\u20132312."},{"key":"210929r17","doi-asserted-by":"crossref","unstructured":"Nakashima T., Naganawa S., Sugiura M. et al.: Visualization of endolymphatic hydrops in patients with Meniere\u2019s disease. Laryngoscope., 2007; 117(3): 415\u2013420.","DOI":"10.1097\/MLG.0b013e31802c300c"},{"key":"210929r18","doi-asserted-by":"crossref","unstructured":"Naganawa S., Nakashima T.: Visualization of endolymphatic hydrops with MR imaging in patients with Meniere\u2019s disease and related pathologies: current status of its methods and clinical significance. Jpn J Radiol., 2014; 32(4): 191\u2013204.","DOI":"10.1007\/s11604-014-0290-4"},{"key":"210929r19","doi-asserted-by":"crossref","unstructured":"Nakashima T., Naganawa S., Pyykko I. et al.: Grading of endolymphatic hydrops using magnetic resonance imaging. Acta Otolaryngol Suppl., 2009(560): 5\u20138.","DOI":"10.1080\/00016480902729827"},{"key":"210929r20","doi-asserted-by":"crossref","unstructured":"Conte G., Lo Russo F.M., Calloni S.F. et al.: MR imaging of endolymphatic hydrops in Meniere\u2019s disease: not all that glitters is gold. Acta Otorhinolaryngol Ital., 2018; 38(4): 369\u2013376.","DOI":"10.14639\/0392-100X-1986"},{"key":"210929r21","doi-asserted-by":"crossref","unstructured":"Attye A., Eliezer M., Boudiaf N. et al.: MRI of endolymphatic hydrops in patients with Meniere\u2019s disease: a case-controlled study with a simplified classification based on saccular morphology. Eur Radiol., 2017; 27(8): 3138\u20133146.","DOI":"10.1007\/s00330-016-4701-z"},{"key":"210929r22","doi-asserted-by":"crossref","unstructured":"Barath K., Schuknecht B., Naldi A.M. et al.: Detection and grading of endolymphatic hydrops in Meniere disease using MR imaging. AJNR Am J Neuroradiol., 2014; 35(7): 1387\u20131392.","DOI":"10.3174\/ajnr.A3856"},{"key":"210929r23","doi-asserted-by":"crossref","unstructured":"Bernaerts A., Vanspauwen R., Blaivie C. et al.: The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Meniere\u2019s disease on MRI. Neuroradiology., 2019; 61(4): 421\u2013429.","DOI":"10.1007\/s00234-019-02155-7"},{"key":"210929r24","doi-asserted-by":"crossref","unstructured":"Kahn L., Hautefort C., Guichard J.P. et al.: Relationship between video head impulse test, ocular and cervical vestibular evoked myogenic potentials, and compartmental magnetic resonance imaging classification in meniere\u2019s disease. Laryngoscope., 2020; 130(7): E444\u2013E52.","DOI":"10.1002\/lary.28362"},{"key":"210929r25","doi-asserted-by":"crossref","unstructured":"Pender D.J.: Membrane Stress in the Human Labyrinth and Meniere Disease: A Model Analysis. Int Arch Otorhinolaryngol., 2015; 19(4): 336\u2013342.","DOI":"10.1055\/s-0035-1549157"},{"key":"210929r26","doi-asserted-by":"crossref","unstructured":"Gurkov R., Berman A., Dietrich O. et al.: MR volumetric assessment of endolymphatic hydrops. Eur Radiol., 2015; 25(2): 585\u2013595.","DOI":"10.1007\/s00330-014-3414-4"},{"key":"210929r27","doi-asserted-by":"crossref","unstructured":"Ito T., Inui H., Miyasaka T. et al.: Endolymphatic volume in patients with meniere\u2019s disease and healthy controls: Three-dimensional analysis with magnetic resonance imaging. Laryngoscope Investig Otolaryngol., 2019; 4(6): 653\u2013658.","DOI":"10.1002\/lio2.313"},{"key":"210929r28","doi-asserted-by":"crossref","unstructured":"Homann G., Vieth V., Weiss D. et al.: Semi-quantitative vs. volumetric determination of endolymphatic space in Meniere\u2019s disease using endolymphatic hydrops 3T-HR-MRI after intravenous gadolinium injection. PLoS One., 2015; 10(3): e0120357.","DOI":"10.1371\/journal.pone.0120357"},{"key":"210929r29","doi-asserted-by":"crossref","unstructured":"Sone M., Naganawa S., Teranishi M. et al.: Changes in endolymphatic hydrops in a patient with Meniere\u2019s disease observed using magnetic resonance imaging. Auris Nasus Larynx., 2010; 37(2): 220\u2013222.","DOI":"10.1016\/j.anl.2009.04.013"},{"key":"210929r30","doi-asserted-by":"crossref","unstructured":"Wu Q., Dai C., Zhao M., Sha Y.: The correlation between symptoms of definite Meniere\u2019s disease and endolymphatic hydrops visualized by magnetic resonance imaging. Laryngoscope., 2016; 126(4): 974\u2013979.","DOI":"10.1002\/lary.25576"},{"key":"210929r31","doi-asserted-by":"crossref","unstructured":"Yoshida T., Sugimoto S., Teranishi M. et al.: Imaging of the endolymphatic space in patients with Meniere\u2019s disease. Auris Nasus Larynx., 2018; 45(1): 33\u201338.","DOI":"10.1016\/j.anl.2017.02.002"},{"key":"210929r32","doi-asserted-by":"crossref","unstructured":"Zhang W., Xie J., Hui L., Li S., Zhang B.: The Correlation Between Endolymphatic Hydrops and blood-labyrinth barrier Permeability of Meniere Disease. Ann Otol Rhinol Laryngol., 2020:3489420964823.","DOI":"10.1177\/0003489420964823"},{"key":"210929r33","doi-asserted-by":"crossref","unstructured":"Gurkov R., Flatz W., Louza J., Strupp M., Krause E.: In vivo visualization of endolyphatic hydrops in patients with Meniere\u2019s disease: correlation with audiovestibular function. Eur Arch Otorhinolaryngol., 2011; 268(12): 1743\u20131748.","DOI":"10.1007\/s00405-011-1573-3"},{"key":"210929r34","doi-asserted-by":"crossref","unstructured":"Seo Y.J., Kim J., Choi J.Y., Lee W.S.: Visualization of endolymphatic hydrops and correlation with audio-vestibular functional testing in patients with definite Meniere\u2019s disease. Auris Nasus Larynx., 2013; 40(2): 167\u2013172.","DOI":"10.1016\/j.anl.2012.07.009"},{"key":"210929r35","doi-asserted-by":"crossref","unstructured":"Shi S., Guo P., Li W., Wang W.: Clinical Features and Endolymphatic Hydrops in Patients With MRI Evidence of Hydrops. Ann Otol Rhinol Laryngol., 2019; 128(4): 286\u2013292.","DOI":"10.1177\/0003489418819551"},{"key":"210929r36","doi-asserted-by":"crossref","unstructured":"Yamamoto M., Teranishi M., Naganawa S. et al.: Relationship between the degree of endolymphatic hydrops and electrocochleography. Audiol Neurootol., 2010; 15(4): 254\u2013260.","DOI":"10.1159\/000258681"},{"key":"210929r37","doi-asserted-by":"crossref","unstructured":"Cho Y.S., Ahn J.M., Choi J.E. et al.: Usefulness of Intravenous Gadolinium Inner Ear MR Imaging in Diagnosis of Meniere\u2019s Disease. Sci Rep., 2018; 8(1): 17562.","DOI":"10.1038\/s41598-018-35709-5"},{"key":"210929r38","doi-asserted-by":"crossref","unstructured":"Kato M., Sugiura M., Shimono M. et al.: Endolymphatic hydrops revealed by magnetic resonance imaging in patients with atypical Meniere\u2019s disease. Acta Otolaryngol., 2013; 133(2): 123\u2013129.","DOI":"10.3109\/00016489.2012.726374"},{"key":"210929r39","doi-asserted-by":"crossref","unstructured":"Rosengren S.M., Govender S., Colebatch J.G.: Ocular and cervical vestibular evoked myogenic potentials produced by air- and bone-conducted stimuli: comparative properties and effects of age. Clin Neurophysiol., 2011; 122(11): 2282\u20132289.","DOI":"10.1016\/j.clinph.2011.04.001"},{"key":"210929r40","doi-asserted-by":"crossref","unstructured":"Govender S., Rosengren S.M., Colebatch J.G.: Vestibular neuritis has selective effects on air- and bone-conducted cervical and ocular vestibular evoked myogenic potentials. Clin Neurophysiol., 2011; 122(6): 1246\u20131255.","DOI":"10.1016\/j.clinph.2010.12.040"},{"key":"210929r41","doi-asserted-by":"crossref","unstructured":"Dlugaiczyk J.: Ocular Vestibular Evoked Myogenic Potentials: Where Are We Now? Otol Neurotol., 2017; 38(10): e513-e21.","DOI":"10.1097\/MAO.0000000000001478"},{"key":"210929r42","doi-asserted-by":"crossref","unstructured":"Phillips J.S., Murdin L., Rea P., Sutton L.: Clinical Subtyping of Meniere\u2019s Disease. Otolaryngol Head Neck Surg., 2018; 159(3): 407\u2013409.","DOI":"10.1177\/0194599818773077"},{"key":"210929r43","doi-asserted-by":"crossref","unstructured":"Lopez-Escamez J.A., Carey J., Chung W.H. et al.: Diagnostic criteria for Meniere\u2019s disease. Consensus document of the Barany Society, the Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology (EAONO), the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and the Korean Balance Society]. Acta Otorrinolaringol Esp., 2016; 67(1): 1\u20137.","DOI":"10.1016\/j.otorri.2015.05.005"},{"key":"210929r44","doi-asserted-by":"crossref","unstructured":"Teranishi M., Naganawa S., Katayama N. et al.: Image evaluation of endolymphatic space in fluctuating hearing loss without vertigo. Eur Arch Otorhinolaryngol., 2009; 266(12): 1871\u20131877.","DOI":"10.1007\/s00405-009-0989-5"},{"key":"210929r45","doi-asserted-by":"crossref","unstructured":"Shimono M., Teranishi M., Yoshida T. et al.: Endolymphatic hydrops revealed by magnetic resonance imaging in patients with acute low-tone sensorineural hearing loss. Otol Neurotol., 2013; 34(7): 1241\u20131246.","DOI":"10.1097\/MAO.0b013e3182990e81"},{"key":"210929r46","doi-asserted-by":"crossref","unstructured":"Kitahara M., Takeda T., Yazawa Y., Matsubara H., Kitano H.: Pathophysiology of Meniere\u2019s disease and its subvarieties. Acta Otolaryngol Suppl., 1984; 406: 52\u201355.","DOI":"10.3109\/00016488309123002"},{"key":"210929r47","doi-asserted-by":"crossref","unstructured":"Shen K.C., Young Y.H.: Lermoyez syndrome revisited: 100-year mystery. Acta Otolaryngol., 2018; 138(11): 981\u2013986.","DOI":"10.1080\/00016489.2018.1498594"},{"key":"210929r48","doi-asserted-by":"crossref","unstructured":"Zhou F., Shi S., Wang D., Guo P., Wang W.: MR imaging and clinical characteristics of Lermoyez syndrome. Acta Otolaryngol., 2020; 140(7): 528\u2013532.","DOI":"10.1080\/00016489.2020.1751275"},{"key":"210929r49","doi-asserted-by":"crossref","unstructured":"Suga K., Kato M., Yoshida T. et al.: Changes in endolymphatic hydrops in patients with Meniere\u2019s disease treated conservatively for more than 1 year. Acta Otolaryngol., 2015; 135(9): 866\u2013870.","DOI":"10.3109\/00016489.2015.1015607"},{"key":"210929r50","doi-asserted-by":"crossref","unstructured":"Gurkov R., Flatz W., Keeser D. et al.: Effect of standard-dose Betahistine on endolymphatic hydrops: an MRI pilot study. Eur Arch Otorhinolaryngol., 2013; 270(4): 1231\u20131235.","DOI":"10.1007\/s00405-012-2087-3"},{"key":"210929r51","doi-asserted-by":"crossref","unstructured":"Fiorino F., Pizzini F.B., Barbieri F., Beltramello A.: Magnetic resonance imaging fails to show evidence of reduced endolymphatic hydrops in gentamicin treatment of Meniere\u2019s disease. Otol Neurotol., 2012; 33(4): 629\u2013633.","DOI":"10.1097\/MAO.0b013e318248ee1f"},{"key":"210929r52","doi-asserted-by":"crossref","unstructured":"Higashi-Shingai K., Imai T., Okumura T. et al.: Change in endolymphatic hydrops 2 years after endolymphatic sac surgery evaluated by MRI. Auris Nasus Larynx., 2019; 46(3): 335\u2013345.","DOI":"10.1016\/j.anl.2018.10.011"},{"key":"210929r53","doi-asserted-by":"crossref","unstructured":"Ito T., Inui H., Miyasaka T. et al.: Three-Dimensional Magnetic Resonance Imaging Reveals the Relationship Between the Control of Vertigo and Decreases in Endolymphatic Hydrops After Endolymphatic Sac Drainage With Steroids for Meniere\u2019s Disease. Front Neurol., 2019; 10: 46.","DOI":"10.3389\/fneur.2019.00046"}],"container-title":["Otolaryngologia Polska"],"original-title":[],"link":[{"URL":"https:\/\/otolaryngologypl.com\/gicid\/pdf\/01.3001.0014.6176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/otolaryngologypl.com\/gicid\/pdf\/01.3001.0014.6176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,5]],"date-time":"2021-05-05T11:14:52Z","timestamp":1620213292000},"score":1,"resource":{"primary":{"URL":"https:\/\/otolaryngologypl.com\/gicid\/01.3001.0014.6176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,29]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,12,29]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0014.6176","relation":{},"ISSN":["0030-6657","2300-8423"],"issn-type":[{"value":"0030-6657","type":"print"},{"value":"2300-8423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,29]]}}}