{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:04:46Z","timestamp":1780481086501,"version":"3.54.1"},"reference-count":29,"publisher":"Index Copernicus","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol Pol"],"published-print":{"date-parts":[[2021,5,12]]},"abstract":"<jats:p>Radiotherapy (RT) for patients with head and neck squamous cell carcinoma (HNSCC) affects vital functions related to the irradiation volume of the head and neck region and, in addition, has a negative impact on social functioning, thereby significantly impairing patients\u2019 quality of life (QoL).\n\nThe aim of this study was to assess changes in the quality of life in patients with head and neck cancer treated with curative RT at 12 months after completion of RT. The aim of this study was to assess the differences between the baseline QoL of patients with early clinical stage HNSCC and at 12 months after curative\/radical RT.\n\nThe prospective clinical study included 92 patients in good general condition (ECOG 0\u20131 \u2013 Eastern Cooperative Oncology Group performance status), without regional or distant metastases, diagnosed with pathomorphologically confirmed early-stage head and neck squamous cell carcinoma treated with definitive RT. All patients participating in the study signed an informed consent form. QoL was assessed using the standard EORTC QLQ-C30 and QLQH&amp;N35 questionnaires. In addition, information on clinical aspects and data relating to socio-demographic factors were obtained from each patient. Statistical analysis was performed using a statistical package (SPSS 17.0). T-test was used for dependent and independent samples. A general linear model was used for repeated measures.\n\nPatients\u2019 QoL deteriorated significantly after definitive RT. Worse QoL Core-30 scores in patients 12 months after the end of RT, compared with baseline QoL, before the start of RT, were observed in domains such as physical performance, fulfillment of life roles, cognitive functioning, loss of appetite, fatigue and constipation. For the QLQ-H&amp;N35 questionnaires, patients 12 months after the end of RT reported problems in relation to aspects of life such as senses, mouth opening, dry mouth, thick saliva, pain, and weight loss.\n\nRT, even in early clinical stage head and neck cancer, has a negative impact on QoL, despite modern treatment techniques.\n\n<\/jats:p>","DOI":"10.5604\/01.3001.0014.8759","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T07:35:51Z","timestamp":1632382551000},"page":"1-8","source":"Crossref","is-referenced-by-count":8,"title":["The impact of radiotherapy on the quality of life\nin patients with early-stage clinical head and\nneck cancer"],"prefix":"10.5604","volume":"75","author":[{"given":"Jakub","family":"Milecki","sequence":"first","affiliation":[{"name":"Medical University of Karol Marcinkowski in Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"\u017bmijewska-Tomczak","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy of the Greater Poland Cancer Center, Medical University of Karol Marcinkowski in Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Osmola","sequence":"additional","affiliation":[{"name":"Maxillofacial Surgery Clinic, Medical University of Karol Marcinkowski in Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Wierzbicka","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology, Medical University of Karol Marcinkowski in Poznan, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","reference":[{"key":"215037r1","doi-asserted-by":"crossref","unstructured":"S\u00f6derlund Schaller A., Dragioti E., Liedberg G.M., Larsson B.: Are patient education and self-care advantageous for patients with head and neck cancer? 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