{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:10:15Z","timestamp":1788635415919,"version":"build-2803163510"},"reference-count":0,"publisher":"Index Copernicus","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol Pol"],"published-print":{"date-parts":[[2025,3,19]]},"abstract":"<jats:p>&lt;b&gt;Aim:&lt;\/b&gt; To assess the use of nasal rinsing with probiotics in patients with rhinitis and rhinosinusitis (primary and secondary).&lt;b&gt;Material and methods:&lt;\/b&gt; A total of 51 patients (31 women and 20 men) were included in the study, including 24 patients with granulomatosis with polyangiitis during immunosuppressive therapy (12 women and 12 men) and 27 patients (19 women and 8 men) with rhinitis (chronic rhinosinusitis with polyps, chronic rhinosinusitis without nasal polyps, atrophic rhinitis with nasal septum perforation, and allergic rhinitis). Exclusion criteria were: cystic fibrosis, primary ciliary dyskinesia, pregnancy, severe lung, heart, kidney disease, use of oral probiotics, use of intranasal probiotics in the last 6 months, sinus surgery in the last 6 months, lack of consent to participate in the study, antibiotic therapy in the last 2 months. Patients were scheduled to have their noses rinsed with a probiotic solution with the following parameters assessed before and after rinsing: SNOT-22 and the severity of nasal lesions on the Lund-Kennedy scale. In the group of patients with rhinitis, the ENS-6 questionnaire was also conducted and symptoms assessed on the VAS scale (visual analogue scale): nasal discharge, nasal obstruction, facial pain, impaired sense of smell, nasal irritation, nasal itching, severity of crusting.&lt;b&gt;Results:&lt;\/b&gt; The study showed that nasal rinsing with a probiotic solution is well tolerated and does not cause any adverse effects. In both groups, a reduction in symptoms was observed based on the SNOT-22 questionnaire (p=0.002 in GPA, ns - in rhinitis\/rhinosinusitis). In the Lund-Kennedy scale, the reduction in the intensity of changes in both groups was statistically significant. In addition, patients with primary rhinitis\/rhinosinusitis also experienced a reduction in nasal mucosa irritation and crusting in the nose (p&lt;0.05).&lt;b&gt;Conclusions:&lt;\/b&gt; Probiotic nasal rinsing has a beneficial effect on the condition of the nasal mucosa in patients with both primary and secondary rhinosinusitis (GPA) and is well tolerated by patients.<\/jats:p>","DOI":"10.5604\/01.3001.0055.0503","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:43:03Z","timestamp":1742370183000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Nasal rinsing with probiotics in rhinosinusitis \u2013 analysis of symptoms and safety assessment"],"prefix":"10.5604","volume":"79","author":[{"given":"Eliza","family":"Bro\u017cek-M\u0105dry","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zofia","family":"Burska","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewelina","family":"Sosnowska-Turek","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, Poland."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","container-title":["Otolaryngologia Polska"],"original-title":[],"deposited":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:43:05Z","timestamp":1742370185000},"score":1,"resource":{"primary":{"URL":"https:\/\/otolaryngologypl.com\/gicid\/01.3001.0055.0503"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,19]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3,19]]}},"URL":"https:\/\/doi.org\/10.5604\/01.3001.0055.0503","relation":{},"ISSN":["0030-6657","2300-8423"],"issn-type":[{"value":"0030-6657","type":"print"},{"value":"2300-8423","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,19]]}}}