{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T11:08:12Z","timestamp":1768216092205,"version":"3.49.0"},"reference-count":29,"publisher":"Index Copernicus","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Otolaryngol Pol"],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<ns3:p>&lt;b&gt;Introduction:&lt;\/b&gt; Basal cell carcinoma (BCC) most commonly affects the sun-exposed head and neck skin, where oncologic clearance must be balanced against functional and cosmetic outcomes. Whether anatomical subsite independently influences achieved histopathological margins is clinically relevant for ENT practice.&lt;b&gt;Aim:&lt;\/b&gt; To assess the association between tumor location and achieved surgical margins (minimum lateral and deep) in head and neck BCC, and to identify subsites most prone to narrow\/positive margins and adverse histopathological features.&lt;b&gt;Materials and methods:&lt;\/b&gt; Retrospective single-centre study of surgically excised head and neck BCCs treated at the Military Medical Institute (Warsaw) between 2018 and 2021. Variables included minimum lateral\/deep margins, maximum tumor dimension, depth of invasion, ulceration, perineural invasion, inflammatory response, Demodex, post-solar hyperplasia, and coexisting lesions (Bowen\u2019s disease, SCC, melanoma). Subsites: forehead, nose, periorbital, perioral, scalp, temporal, periauricular. Kruskal\u2013Wallis and \u03c7\/Fisher\u2019s exact tests were used (\u03b1 = 0.05).&lt;b&gt;Results:&lt;\/b&gt; Location significantly influenced margins and histopathology. Periorbital lesions had the largest median deep margins, whereas the nose had the smallest ones. Forehead tumors achieved the widest lateral margins, while periorbital\/perioral subsites the narrowest ones. Perioral lesions showed the greatest depth of invasion; the temporal region the smallest one. Scalp tumors presented with the largest maximum dimension. Nasal lesions most frequently exhibited perineural invasion and ulceration. Demodex was most common on the nose; coexisting Bowen\u2019s disease and melanoma also clustered nasally, while SCC clustered periauricularly.&lt;b&gt;Discussion:&lt;\/b&gt; Findings reflect local anatomy and organ-preserving constraints in central facial subsites and support location-tailored surgical planning.&lt;b&gt;Conclusions:&lt;\/b&gt; Anatomical subsite is a key determinant of achievable margins and adverse features in head and neck BCC, arguing for subsite-adapted strategies and audits of guideline adherence by location.<\/ns3:p>","DOI":"10.5604\/01.3001.0055.4389","type":"journal-article","created":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T07:55:41Z","timestamp":1768204541000},"page":"21-28","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Anatomical Subsite on Achieved Surgical Margins in Head and Neck Basal Cell Carcinoma"],"prefix":"10.5604","volume":"79","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-2910","authenticated-orcid":false,"given":"Jakub","family":"Nicer","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with the Clinical Department of Cranio-Maxillofacial Surgery of the Military Institute of Medicine \u2013 National Research Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Kania","sequence":"additional","affiliation":[{"name":"Department of Patomorphology, Military Institute of Medicine-National Research Institute, Central Clinical Hospital Ministry of Defence, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-0687","authenticated-orcid":false,"given":"Maria","family":"Sobol","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Physiology and Pathophysiology, Faculty of Health Sciences, Medical University of Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-2679","authenticated-orcid":false,"given":"Dariusz","family":"Jurkiewicz","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with the Clinical Department of Cranio-Maxillofacial Surgery of the Military Institute of Medicine \u2013 National Research Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Rot","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Laryngological Oncology with the Clinical Department of Cranio-Maxillofacial Surgery of the Military Institute of Medicine \u2013 National Research Institute, Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"3689","reference":[{"key":"633723r1","unstructured":"Marzuka A.G., Book S.E.: Basal cell carcinoma: pathogenesis, epidemiology,clinical features, diagnosis, histopathology, and management. 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