{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T14:59:16Z","timestamp":1781017156123,"version":"3.54.1"},"reference-count":31,"publisher":"Index Copernicus","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pol Przegl Chir"],"published-print":{"date-parts":[[2026,1,27]]},"abstract":"<b>Introduction:<\/b> Colorectal cancer (CRC) is the second most common cancer worldwide. Much attention has recently been paid to the epigenetic features of CRC. Homologous recombination repair (HRR) is a biochemical pathway that plays a crucial role in maintaining genome integrity through the repair of double-strand breaks (DBS). <i>RAD51<\/i> recombinase is widely considered a key enzyme in HRR. Genome-wide single nucleotide polymorphisms (SNPs) are a significant type of genetic variation.<b>Aim:<\/b> The aim of this study was to assess the association between the occurrence of individual genotypes\/alleles of the <i>RAD51<\/i> 172G\/T polymorphism (rs1801321) and the risk of CRC.<b>Materials and methods:<\/b> The material used for DNA isolation was peripheral blood from patients at the Department of General and Colorectal Surgery, Medical University of Lodz. The study recruited patients (n = 188) with histologically confirmed colorectal cancer. The control group consisted of undiagnosed individuals (n = 200), matched for age and gender, without a family history of cancer among first-degree relatives.<b>Results:<\/b> No statistically significant association was found between the frequency of the assessed alleles\/genotypes and the presence of CRC. The analysis also showed that the 127G\/T variant of the RAD51 gene was not statistically significantly associated with the development of colorectal cancer.<b>Discussion:<\/b> The 127G\/T polymorphism of the <i>RAD51<\/i> gene appears to be an unpromising marker for colorectal cancer. However, new observations regarding the variant in the distal promoter may open up prospects for future research on molecular markers.<b>Conclusions:<\/b> The study results indicate no association between the <i>RAD51<\/i> 172G\/T polymorphism and the risk of CRC. Therefore, there is a need for further research in the area of selected polymorphisms in CRC.<\/ns3:p>","DOI":"10.5604\/01.3001.0055.5916","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T08:56:52Z","timestamp":1770973012000},"page":"13-18","source":"Crossref","is-referenced-by-count":0,"title":["Analysis of correlation between RAD51 172G\/T polymorphism and colorectal cancer in the Polish population"],"prefix":"10.5604","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-5650","authenticated-orcid":false,"given":"Beata","family":"Filipek","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9757-2261","authenticated-orcid":false,"given":"Dawid","family":"Lewko","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6173-4525","authenticated-orcid":false,"given":"Aleksandra","family":"Binda","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9300-024X","authenticated-orcid":false,"given":"Bartosz","family":"Mucha","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0390-0827","authenticated-orcid":false,"given":"Lukasz","family":"Dziki","sequence":"additional","affiliation":[{"name":"Department of General and Colorectal Surgery, Medical University of Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5439-6237","authenticated-orcid":false,"given":"Adam","family":"Dziki","sequence":"additional","affiliation":[{"name":"Department of General and Colorectal Surgery, Medical University of Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6231-3334","authenticated-orcid":false,"given":"Ireneusz","family":"Majsterek","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Biochemistry, Medical University of Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3689","reference":[{"key":"635861r1","doi-asserted-by":"crossref","unstructured":"Xi Y., Xu P.: Global colorectal cancer burden in 2020 and projections to 2040.Transl Oncol., 2021; 14(10): 101174. doi: 10.1016\/j.tranon.2021.101174.","DOI":"10.1016\/j.tranon.2021.101174"},{"key":"635861r2","doi-asserted-by":"crossref","unstructured":"Walther A., Johnstone E., Swanton C. et al.: Genetic prognostic and predictivemarkers in colorectal cancer. 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