{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:57:04Z","timestamp":1788965824755,"version":"build-2803163510"},"reference-count":12,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T00:00:00Z","timestamp":1559174400000},"content-version":"vor","delay-in-days":1124,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Annals of Hepatology"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.5604\/16652681.1198826","type":"journal-article","created":{"date-parts":[[2016,4,5]],"date-time":"2016-04-05T08:04:31Z","timestamp":1459843471000},"page":"453-454","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Bile acids and the risk for hepatocellular carcinoma in primary biliary cholangitis"],"prefix":"10.1016","volume":"15","author":[{"given":"Alejandra","family":"Altamirano-Barrera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misael","family":"Uribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahum","family":"M\u00e9ndez-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.5604\/16652681.1198826_bib0005","first-page":"S4","article-title":"Latin American Association for the Study of the Liver (LAASL) Clinical Practice Guidelines: management of hepatocellular carcinoma.","volume":"13","author":"M\u00e9ndez-S\u00e1nchez","year":"2014","journal-title":"Ann Hepatol"},{"key":"10.5604\/16652681.1198826_bib0010","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S1665-2681(19)30838-5","article-title":"Predicting outcome in primary biliary cirrhosis.","volume":"13","author":"Lammers","year":"2014","journal-title":"Ann Hepatol"},{"key":"10.5604\/16652681.1198826_bib0015","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.cgh.2011.09.013","article-title":"Long-term outcomes of patients with primary biliary cirrhosis and hepatocellular carcinoma.","volume":"10","author":"Imam","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.5604\/16652681.1198826_bib0020","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/gutjnl-2014-308351","article-title":"Stratification of hepatocellular carcinoma risk in primary biliary cirrhosis: a multicentre international study.","volume":"65","author":"Trivedi","year":"2016","journal-title":"Gut"},{"key":"10.5604\/16652681.1198826_bib0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/hep.25788","article-title":"Primary biliary cirrhosis and cancer risk: a systematic review and meta-analysis.","volume":"56","author":"Liang","year":"2012","journal-title":"Hepatology"},{"key":"10.5604\/16652681.1198826_bib0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1126\/science.1140485","article-title":"Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production.","volume":"317","author":"Naugler","year":"2007","journal-title":"Science"},{"issue":"10003","key":"10.5604\/16652681.1198826_bib0035","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1016\/S0140-6736(15)00154-3","article-title":"Primary biliary cirrhosis.","volume":"386","author":"Carey","year":"2015","journal-title":"Lancet"},{"key":"10.5604\/16652681.1198826_bib0040","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ncpgasthep0521","article-title":"Drug insight: Mechanisms and sites of action of ursodeoxycholic acid in cholestasis.","volume":"3","author":"Beuers","year":"2006","journal-title":"Nat Clin Pract Gastroenterol Hepatol"},{"key":"10.5604\/16652681.1198826_bib0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1742-7843.2011.00792.x","article-title":"Gender, but not CYP7A1 or SLCO1B1 polymorphism, affects the fasting plasma concentrations of bile acids in human beings.","volume":"110","author":"Xiang","year":"2012","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.5604\/16652681.1198826_bib0050","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0026-0495(78)90140-3","article-title":"Sex differences in the size of bile acid pools.","volume":"27","author":"Bennion","year":"1978","journal-title":"Metabolism"},{"key":"10.5604\/16652681.1198826_bib0055","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jhep.2012.02.014","article-title":"Effect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health.","volume":"57","author":"Dilger","year":"2012","journal-title":"J Hepatol"},{"key":"10.5604\/16652681.1198826_bib0060","first-page":"1449","article-title":"Targeting FXR in cholestasis: hype or hope.","volume":"18","author":"Fiorucci","year":"2014","journal-title":"Expert Opin Ther Targets"}],"container-title":["Annals of Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119306672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1665268119306672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/publisherspanel.com\/icid\/pdf\/1198826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:35:20Z","timestamp":1761647720000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1665268119306672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["S1665268119306672"],"URL":"https:\/\/doi.org\/10.5604\/16652681.1198826","relation":{},"ISSN":["1665-2681"],"issn-type":[{"value":"1665-2681","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bile acids and the risk for hepatocellular carcinoma in primary biliary cholangitis","name":"articletitle","label":"Article Title"},{"value":"Annals of Hepatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.5604\/16652681.1198826","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2016 Fundaci\u00f3n Cl\u00ednica M\u00e9dica Sur, A.C. Published by Elsevier Espa\u00f1a, S.L.","name":"copyright","label":"Copyright"}]}}