{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:05:10Z","timestamp":1780067110595,"version":"3.54.0"},"reference-count":29,"publisher":"Polish Society of Microbiologists","issue":"1","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Group A\n                    <jats:italic>Streptococcus<\/jats:italic>\n                    (GAS) is a Gram-positive human pathogen that causes a variety of diseases ranging from pharyngitis to life-threatening streptococcal toxic shock syndrome. Recently, several global gene expression analyses have yielded extensive new information regarding the regulation of genes encoding known and putative virulence factors in GAS. A microarray analysis found that transcription of the GAS gene\n                    <jats:italic>M5005_Spy_1343<\/jats:italic>\n                    was significantly increased in response to interaction with human polymorphonuclear leukocytes.\n                    <jats:italic>M5005_Spy_1343<\/jats:italic>\n                    is predicted to encode a member of the LysR family of transcriptional regulators and is located upstream of a putative operon containing six genes. Five of these genes have sequence similarity to genes involved in short-chain fatty acid metabolism, whereas the sixth gene (\n                    <jats:italic>lux<\/jats:italic>\n                    S) is found in many bacterial species and is involved in quorum sensing. Unexpectedly, inactivation of the\n                    <jats:italic>M5005_Spy_1343<\/jats:italic>\n                    gene resulted in hypervirulence in an intraperitoneal mouse model of infection. Increased virulence was not due to changes in\n                    <jats:italic>lux<\/jats:italic>\n                    S gene expression. We postulate that short-chain fatty acid metabolism is involved in GAS pathogenesis.\n                  <\/jats:p>","DOI":"10.5604\/17331331.1234989","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T10:16:23Z","timestamp":1491560183000},"page":"17-24","source":"Crossref","is-referenced-by-count":4,"title":["Deletion of\n                    <i>ato<\/i>\n                    R from\n                    <i>Streptococcus pyogenes<\/i>\n                    Results in Hypervirulence in a Mouse Model of Sepsis and is LuxS Independent"],"prefix":"10.33073","volume":"66","author":[{"given":"IZABELA","family":"SITKIEWICZ","sequence":"first","affiliation":[{"name":"Department of Molecular Microbiology , National Medicines Institute , Warsaw , Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JAMES M.","family":"MUSSER","sequence":"additional","affiliation":[{"name":"Center for Molecular and Translational Human Infectious Diseases Research , Houston Methodist Research Institute, and Department of Pathology and Genomic Medicine , Houston Methodist Hospital , Houston, Texas , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18083","published-online":{"date-parts":[[2017,3,30]]},"reference":[{"key":"2026052913574545841_j_17331331.1234989_ref_001","doi-asserted-by":"crossref","unstructured":"Banks D.J., S.F. 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