{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:11:10Z","timestamp":1793067070337,"version":"4.5.0"},"reference-count":0,"publisher":"AVES YAYINCILIK A.\u015e.","issue":"1","license":[{"start":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T00:00:00Z","timestamp":1459382400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Archives of Rheumatology"],"abstract":"<jats:p>Objectives: This study aims to investigate the genetic association between single nucleotide mutation in mitochondrial manganese superoxide dismutase and a Beh\u00e7et\u2019s disease (BD) population by using molecular techniques.\r\nPatients and methods: Ninety-three BD patients (45 males, 48 females; mean age 33.15\u00b18.99 years; range 17 to 65 years) and 125 controls (58 males, 67 females; mean age 28.33\u00b17.31 years; range 18 to 62 years) were genotyped by polymerase chain reaction-restriction fragment length polymorphism method. The genotypic distributions in BD patients and controls were consistent with the Hardy-Weinberg equilibrium.\r\nResults: Significant differences were observed between BD patients and controls in terms of genotypic distribution. Frequencies of alanine (Ala)\/Ala, Ala\/valine (Val), and Val\/Val were 14.0% (n=13), 45.2% (n=42), and 40.9% (n=38) in BD patients and 21.6% (n=27), 53.6% (n=67), and 24.8% (n=31) in controls, respectively (p=0.033).\r\nConclusion: The Val\/Val genotype of the manganese superoxide dismutase gene is associated with the physiopathology of BD in a group of Turkish patients.<\/jats:p>","DOI":"10.5606\/archrheumatol.2016.5645","type":"journal-article","created":{"date-parts":[[2016,4,27]],"date-time":"2016-04-27T02:13:25Z","timestamp":1461723205000},"page":"048-054","source":"Crossref","is-referenced-by-count":3,"title":["Genetic Polymorphism of Manganese Superoxide Dismutase in Beh\u00e7et\u2019s Disease"],"prefix":"10.5152","volume":"31","author":[{"family":"Efkan UZ","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"H. Ramazan YILMAZ","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ramazan YA\u011eCI","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"\u0130smail AKYOL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Tu\u011fba ERSOY","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"G\u00fclten SUNGUR","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Ay\u015fe Y\u0130\u011e\u0130T","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Sunay DUMAN","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"\u00d6mer AKYOL","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3111","published-online":{"date-parts":[[2016,3,31]]},"container-title":["Archives of Rheumatology"],"original-title":[],"link":[{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/769\/1232","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/769\/1233","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/download\/769\/1232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T10:41:55Z","timestamp":1761216115000},"score":1,"resource":{"primary":{"URL":"https:\/\/archivesofrheumatology.org\/index.php\/pub\/article\/view\/769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,31]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,3,31]]}},"URL":"https:\/\/doi.org\/10.5606\/archrheumatol.2016.5645","relation":{},"ISSN":["2618-6500"],"issn-type":[{"value":"2618-6500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,31]]}}}