{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:21:06Z","timestamp":1783066866548,"version":"3.54.6"},"reference-count":26,"publisher":"Galenos Yayinevi","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Phys Med Rehab"],"accepted":{"date-parts":[[2024,7,2]]},"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    The primary objective of this study was to assess and compare the response to the breast cancer-related lymphedema (BCRL) treatment with Breast Cancer-Related Lymphedema of the Upper Extremity (CLUE) scores, bioimpedance spectroscopy (BIS), and the volume-assessments \/measurements. The secondary objective of the study was to investigate whether CLUE played a role in the treatment response and to examine its correlation with the other measures of lymphedema.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    Between January 2019 and June 2019, a total of 40 patients (2 males, 38 females; mean age: 57.8\u00b112.5 years; range, 45 to 70 years) who were diagnosed with unilateral Stage 2-3 BCRL and underwent treatment were included. The patients\u2019 upper extremity volumes were assessed and the patients were evaluated with the CLUE score, the Disabilities of the Arm, Shoulder, and Hand Outcome Measure (QuickDASH) score, BIS, and hand grip strength before and after the complete decongestive therapy.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Correlation analyses revealed that CLUE total score and BIS values were correlated with the reduction in the volumes (p=0.04 and p&lt;0.001, respectively). The CLUE total score was also found to be positively correlated with the BIS values (p&lt;0.001). Hand grip strength and QuickDASH scores were not found to be correlated with the changes in the volume and CLUE total scores.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The development of a structured clinical assessment such as CLUE provides clinicians for a standardized evaluation for BCRL. The diagnosis of subclinical lymphedema can be detected earlier by using the BIS and CLUE scale and lymphedema comorbidity and treatment costs can be reduced.\n                  <\/jats:p>","DOI":"10.5606\/tftrd.2024.14691","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T01:36:02Z","timestamp":1746754562000},"page":"109-116","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of response to treatment in breast cancer-related lymphedema"],"prefix":"10.4274","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5543-4541","authenticated-orcid":false,"given":"Ezgi","family":"Y\u0131ld\u0131z G\u00fcvercin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-2712","authenticated-orcid":false,"given":"Sibel","family":"Eyig\u00f6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9710-1582","authenticated-orcid":false,"given":"Ece","family":"\u00c7\u0131nar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6456-7012","authenticated-orcid":false,"given":"G\u00f6ksel","family":"Tan\u0131g\u00f6r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3080-1389","authenticated-orcid":false,"given":"Menek\u015fe","family":"\u00d6zg\u00fcr \u0130nbat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5644-9486","authenticated-orcid":false,"given":"Sedef","family":"\u00c7al\u0131\u015fkan Kabayel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Salonen P, Rantanen A, Kellokumpu-Lehtinen PL, Huhtala H, Kaunonen M. The quality of life and social support in significant others of patients with breast cancer--a longitudinal study. Eur J Cancer Care (Engl) 2014;23:274- 83. doi: 10.1111\/ecc.12153.","DOI":"10.1111\/ecc.12153"},{"key":"ref-2","doi-asserted-by":"crossref","unstructured":"Paiva DM, Rodrigues VO, Cesca MG, Palma PV, Leite IC. Prevalence of lymphedema in women undergoing treatment for breast cancer in a referral center in southeastern Brazil. BMC Womens Health 2013;13:6. doi: 10.1186\/1472-6874-13-6.","DOI":"10.1186\/1472-6874-13-6"},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"Gillespie TC, Sayegh HE, Brunelle CL, Daniell KM, Taghian AG. Breast cancer-related lymphedema: Risk factors, precautionary measures, and treatments. Gland Surg 2018;7:379-403. doi: 10.21037\/gs.2017.11.04.","DOI":"10.21037\/gs.2017.11.04"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Ozaslan C, Kuru B. Lymphedema after treatment of breast cancer. Am J Surg 2004;187:69-72. doi: 10.1016\/j. amjsurg.2002.12.003.","DOI":"10.1016\/j.amjsurg.2002.12.003"},{"key":"ref-5","doi-asserted-by":"crossref","unstructured":"Kay\u0131ran O, De La Cruz C, Tane K, Soran A. Lymphedema: From diagnosis to treatment. Turk J Surg 2017;33:51-7. doi: 10.5152\/turkjsurg.2017.3870.","DOI":"10.5152\/turkjsurg.2017.3870"},{"key":"ref-6","doi-asserted-by":"crossref","unstructured":"Reichart K. Lymphedema: Improving screening and treatment among at-risk breast cancer survivors. Clin J Oncol Nurs 2017;21:21-5. doi: 10.1188\/17.CJON.21-25.","DOI":"10.1188\/17.CJON.21-25"},{"key":"ref-7","doi-asserted-by":"crossref","unstructured":"Stout Gergich NL, Pfalzer LA, McGarvey C, Springer B, Gerber LH, Soballe P. Preoperative assessment enables the early diagnosis and successful treatment of lymphedema. Cancer 2008;112:2809-19. doi: 10.1002\/cncr.23494.","DOI":"10.1002\/cncr.23494"},{"key":"ref-8","doi-asserted-by":"crossref","unstructured":"Spinelli B, Kallan MJ, Zhang X, Cheville A, Troxel A, Cohn J, et al. Intra- and interrater reliability and concurrent validity of a new tool for assessment of breast cancerrelated lymphedema of the upper extremity. Arch Phys Med Rehabil 2019;100:315-26. doi: 10.1016\/j.apmr.2018.08.185.","DOI":"10.1016\/j.apmr.2018.08.185"},{"key":"ref-9","doi-asserted-by":"crossref","unstructured":"Forner-Cordero I, Mu\u00f1oz-Langa J, Forner-Cordero A, DeMiguel-Jimeno JM. Predictive factors of response to decongestive therapy in patients with breast-cancer-related lymphedema. Ann Surg Oncol 2010;17:744-51. doi: 10.1245\/ s10434-009-0778-9.","DOI":"10.1245\/s10434-009-0778-9"},{"key":"ref-10","doi-asserted-by":"crossref","unstructured":"Hayes S, Di Sipio T, Rye S, L\u00f3pez JA, Saunders C, Pyke C, et al. Prevalence and prognostic significance of secondary lymphedema following breast cancer. Lymphat Res Biol 2011;9:135-41. doi: 10.1089\/lrb.2011.0007.","DOI":"10.1089\/lrb.2011.0007"},{"key":"ref-11","doi-asserted-by":"crossref","unstructured":"Liao SF, Li SH, Huang HY, Chen ST, Kuo SJ, Chen DR, et al. The efficacy of Complex Decongestive Physiotherapy (CDP) and predictive factors of lymphedema severity and response to CDP in Breast Cancer-Related Lymphedema (BCRL). Breast 2013;22:703-6. doi: 10.1016\/j.breast.2012.12.018.","DOI":"10.1016\/j.breast.2012.12.018"},{"key":"ref-12","doi-asserted-by":"crossref","unstructured":"Yakut E, D\u00fcger T, Oks\u00fcz C, Y\u00f6r\u00fckan S, Ureten K, Turan D, et al. Validation of the Turkish version of the Oswestry Disability Index for patients with low back pain. Spine (Phila Pa 1976) 2004;29:581-5; doi: 10.1097\/01. brs.0000113869.13209.03.","DOI":"10.1097\/01.BRS.0000113869.13209.03"},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Avila ML, Ward LC, Feldman BM, Montoya MI, Stinson J, Kiss A, et al. Normal values for segmental bioimpedance spectroscopy in pediatric patients. PLoS One 2015;10:e0126268. doi: 10.1371\/journal.pone.0126268.","DOI":"10.1371\/journal.pone.0126268"},{"key":"ref-14","doi-asserted-by":"crossref","unstructured":"Shechtman O, Gestewitz L, Kimble C. Reliability and validity of the DynEx dynamometer. J Hand Ther 2005;18:339-47. doi: 10.1197\/j.jht.2005.04.002.","DOI":"10.1197\/j.jht.2005.04.002"},{"key":"ref-15","doi-asserted-by":"crossref","unstructured":"Lanza M, Bergmann A, Ferreira MG, de Aguiar SS, Dias Rde A, Abrah\u00e3o Kde S, et al. Quality of life and volume reduction in women with secondary lymphoedema related to breast cancer. Int J Breast Cancer 2015;2015:586827. doi: 10.1155\/2015\/586827.","DOI":"10.1155\/2015\/586827"},{"key":"ref-16","doi-asserted-by":"crossref","unstructured":"Damstra RJ, Voesten HG, van Schelven WD, van der Lei B. Lymphatic Venous Anastomosis (LVA) for treatment of secondary arm lymphedema. A prospective study of 11 LVA procedures in 10 patients with breast cancer related lymphedema and a critical review of the literature. Breast Cancer Res Treat 2009;113:199-206. doi: 10.1007\/s10549- 008-9932-5.","DOI":"10.1007\/s10549-008-9932-5"},{"key":"ref-17","doi-asserted-by":"crossref","unstructured":"Baklaci M, Eyig\u00f6r S, Tan\u0131g\u00f6r G, \u00d6zg\u00fcr \u0130nbat M, \u00c7al\u0131\u015fkan Kabayel S. Assessment of muscle strength and volume changes in patients with breast cancer-related lymphedema. Oncol Res Treat 2020;43:584-91. doi: 10.1159\/000509672.","DOI":"10.1159\/000509672"},{"key":"ref-18","doi-asserted-by":"crossref","unstructured":"Schober P, Boer C, Schwarte LA. Correlation coefficients: Appropriate use and interpretation. Anesth Analg 2018 May;126:1763-8. doi: 10.1213\/ANE.0000000000002864.","DOI":"10.1213\/ANE.0000000000002864"},{"key":"ref-19","doi-asserted-by":"crossref","unstructured":"Schmitz KH, Troxel AB, Dean LT, DeMichele A, Brown JC, Sturgeon K, et al. Effect of home-based exercise and weight loss programs on breast cancerrelated lymphedema outcomes among overweight breast cancer survivors: The WISER survivor randomized clinical trial. JAMA Oncol 2019;5:1605-13. doi: 10.1001\/ jamaoncol.2019.2109.","DOI":"10.1001\/jamaoncol.2019.2109"},{"key":"ref-20","doi-asserted-by":"crossref","unstructured":"O\u2019Neill J, Beatus J. The effects of complete decongestive physical therapy treatment on edema reduction, quality of life, and functional ability of persons with upper extremity lymphedema. Journal of Women\u2019s Health Physical Therapy 2006;30:5-10.","DOI":"10.1097\/01274882-200630010-00002"},{"key":"ref-21","doi-asserted-by":"crossref","unstructured":"Shah C, Whitworth P, Valente S, Schwarz GS, Kruse M, Kohli M, et al. Bioimpedance spectroscopy for breast cancer-related lymphedema assessment: Clinical practice guidelines. Breast Cancer Res Treat 2023;198:1-9. doi: 10.1007\/s10549-022-06850-7.","DOI":"10.1007\/s10549-022-06850-7"},{"key":"ref-22","doi-asserted-by":"crossref","unstructured":"Stout NL, Pfalzer LA, Springer B, Levy E, McGarvey CL, Danoff JV, et al. Breast cancer-related lymphedema: Comparing direct costs of a prospective surveillance model and a traditional model of care. Phys Ther 2012;92:152-63. doi: 10.2522\/ptj.20100167.","DOI":"10.2522\/ptj.20100167"},{"key":"ref-23","doi-asserted-by":"crossref","unstructured":"Gencay Can A, Can SS, Ek\u015fio\u011flu E, \u00c7akc\u0131 FA. Is kinesiophobia associated with lymphedema, upper extremity function, and psychological morbidity in breast cancer survivors? Turk J Phys Med Rehabil 2018;65:139-46. doi: 10.5606\/tftrd.2019.2585.","DOI":"10.5606\/tftrd.2019.2585"},{"key":"ref-24","doi-asserted-by":"crossref","unstructured":"Johansson K, Ingvar C, Albertsson M, Ekdahl C. Arm lymphoedema, shoulder mobility and muscle strength after breast cancer treatment? A prospective 2-year study. Adv Physiother 2001;3:55-66. doi. org\/10.1080\/14038190119371.","DOI":"10.1080\/140381901300165026"},{"key":"ref-25","doi-asserted-by":"crossref","unstructured":"Rockson SG. Ultrasonography in the evaluation of breast cancer-related lymphedema. Lymphat Res Biol 2016;14:1. doi: 10.1089\/lrb.2016.28999.sgr.","DOI":"10.1089\/lrb.2016.28999.sgr"},{"key":"ref-26","doi-asserted-by":"crossref","unstructured":"Suehiro K, Morikage N, Murakami M, Yamashita O, Samura M, Hamano K. Significance of ultrasound examination of skin and subcutaneous tissue in secondary lower extremity lymphedema. Ann Vasc Dis 2013;6:180-8. doi: 10.3400\/avd. oa.12.00102.","DOI":"10.3400\/avd.oa.12.00102"}],"container-title":["Turkish Journal of Physical Medicine and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ftrdergisi.com\/uploads\/pdf\/pdf_4563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ftrdergisi.com\/uploads\/pdf\/pdf_4563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:08:28Z","timestamp":1783066108000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ftrdergisi.com\/uploads\/pdf\/pdf_4563.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":26,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,3,1]]}},"URL":"https:\/\/doi.org\/10.5606\/tftrd.2024.14691","relation":{},"ISSN":["2587-1250"],"issn-type":[{"value":"2587-1250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]}}}