{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:21:16Z","timestamp":1783066876272,"version":"3.54.6"},"reference-count":36,"publisher":"Galenos Yayinevi","issue":"1","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Phys Med Rehab"],"accepted":{"date-parts":[[2024,7,23]]},"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    This study aims to evaluate the monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), plateletto-lymphocyte ratio (PLR), and C-reactive protein (CRP)-to-albumin ratio levels between individuals with mild to moderate knee osteoarthritis (OA) and those with severe knee OA.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    One hundred eighty-two participants (131 females, 51 males; mean age: 67.7\u00b110.2 years; range, 43 to 91 years) affected by knee OA were involved in the cross-sectional retrospective study between January 2018 and January 2021. Kellgren and Lawrence (K-L) classification was performed in accordance with two-view (lateral and anteroposterior) plain radiograph examinations of each knee. The patients were grouped as follows: 98 patients had mild to moderate knee OA (K-L Grades 1-2), and 84 had severe knee OA (K-L Grades 3-4). Demographic data, neutrophil, monocyte, platelet, and lymphocyte levels, erythrocyte sedimentation rate, albumin, and CRP levels were documented. C-reactive protein-to-albumin ratio, NLR, MLR, and PLR levels were calculated.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    The MLR was significantly elevated in the severe knee OA group (p=0.047). A significant positive relationship was found with disease stage, MLR (r=0.206; p=0.005), and NLR levels (r=0.158; p=0.033). Receiver operating characteristic curve analyses for blood MLR demonstrated a sensitivity of 57% and specificity of 60%.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    The study results suggest that while MLR and NLR may reflect the inflammatory response in knee OA, they are not highly diagnostic inflammatory markers that can be used to evaluate the severity or prognosis of the disease.\n                  <\/jats:p>","DOI":"10.5606\/tftrd.2024.14862","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T01:36:02Z","timestamp":1746754562000},"page":"102-108","source":"Crossref","is-referenced-by-count":4,"title":["Is there a relationship between blood inflammation markers and the severity of knee osteoarthritis?"],"prefix":"10.4274","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-2145","authenticated-orcid":false,"given":"Nazl\u0131","family":"Karaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2314-271X","authenticated-orcid":false,"given":"Asl\u0131han","family":"Ulusoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8181-6639","authenticated-orcid":false,"given":"Mehmet","family":"Karaman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2024,10,31]]},"reference":[{"key":"ref-1","unstructured":"G\u00fcler Uysal F, Ba\u015faran S. Diz osteoartriti. T\u00fcrk Fiz T\u0131p Rehab Derg 2009:55 \u00d6zel Say 1;1-7."},{"key":"ref-2","doi-asserted-by":"crossref","unstructured":"Lespasio MJ, Piuzzi NS, Husni ME, Muschler GF, Guarino A, Mont MA. Knee osteoarthritis: A primer. Perm J 2017;21:16-183. doi: 10.7812\/TPP\/16-183.","DOI":"10.7812\/TPP\/16-183"},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"Kan HS, Chan PK, Chiu KY, Yan CH, Yeung SS, Ng YL, et al. Non-surgical treatment of knee osteoarthritis. Hong Kong Med J 2019;25:127-33. doi: 10.12809\/hkmj187600.","DOI":"10.12809\/hkmj187600"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Katz JN, Arant KR, Loeser RF. Diagnosis and treatment of hip and knee osteoarthritis: A review. JAMA 2021;325:568- 78. doi: 10.1001\/jama.2020.22171.","DOI":"10.1001\/jama.2020.22171"},{"key":"ref-5","doi-asserted-by":"crossref","unstructured":"Jang S, Lee K, Ju JH. Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee. Int J Mol Sci 2021;22:2619. doi: 10.3390\/ ijms22052619.","DOI":"10.3390\/ijms22052619"},{"key":"ref-6","doi-asserted-by":"crossref","unstructured":"Barbosa GGA, Vicente FC, Fagundes MAR, Dornelles LME, Guimar\u00e3es MR, Diesel CV. Is there a relationship between the neutrophil\/lymphocyte ratio and bilaterality in patients with coxarthrosis? Rev Bras Ortop 2018;53:778-82. doi: 10.1016\/j.rboe.2017.09.011.","DOI":"10.1016\/j.rboe.2017.09.011"},{"key":"ref-7","doi-asserted-by":"crossref","unstructured":"Batushansky A, Zhu S, Komaravolu RK, South S, MehtaD'souza P, Griffin TM. Fundamentals of OA. An initiative of Osteoarthritis and Cartilage. Obesity and metabolic factors in OA. Osteoarthritis Cartilage 2022;30:501-15. doi: 10.1016\/j.joca.2021.06.013.","DOI":"10.1016\/j.joca.2021.06.013"},{"key":"ref-8","doi-asserted-by":"crossref","unstructured":"Aubourg G, Rice SJ, Bruce-Wootton P, Loughlin J. Genetics of osteoarthritis. Osteoarthritis Cartilage 2022;30:636-49. doi: 10.1016\/j.joca.2021.03.002.","DOI":"10.1016\/j.joca.2021.03.002"},{"key":"ref-9","doi-asserted-by":"crossref","unstructured":"Young DA, Barter MJ, Soul J. Osteoarthritis year in review: Genetics, genomics, epigenetics. Osteoarthritis Cartilage 2022;30:216-25. doi: 10.1016\/j.joca.2021.11.004.","DOI":"10.1016\/j.joca.2021.11.004"},{"key":"ref-10","doi-asserted-by":"crossref","unstructured":"Gao K, Zhu W, Liu W, Ma D, Li H, Yu W, et al. Diagnostic value of the blood monocyte-lymphocyte ratio in knee osteoarthritis. J Int Med Res 2019;47:4413-21. doi: 10.1177\/0300060519860686.","DOI":"10.1177\/0300060519860686"},{"key":"ref-11","doi-asserted-by":"crossref","unstructured":"Mobasheri A, Henrotin Y. Biomarkers of (osteo) arthritis. Biomarkers 2015;20:513-8. doi: 10.3109\/1354750X.2016.1140930.","DOI":"10.3109\/1354750X.2016.1140930"},{"key":"ref-12","doi-asserted-by":"crossref","unstructured":"Jin Z, Cai G, Zhang P, Li X, Yao S, Zhuang L, et al. The value of the neutrophil-to-lymphocyte ratio and plateletto-lymphocyte ratio as complementary diagnostic tools in the diagnosis of rheumatoid arthritis: A multicenter retrospective study. J Clin Lab Anal 2021;35:e23569. doi: 10.1002\/jcla.23569.","DOI":"10.1002\/jcla.23569"},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Kellgren JH, Lawrence JS. Radiological assessment of osteoarthrosis. Ann Rheum Dis 1957;16:494-502. doi: 10.1136\/ ard.16.4.494.","DOI":"10.1136\/ard.16.4.494"},{"key":"ref-14","doi-asserted-by":"crossref","unstructured":"Ta\u015fo\u011flu \u00d6, B\u00f6l\u00fck H, \u015eahin Onat \u015e, Ta\u015fo\u011flu \u0130, \u00d6zgirgin N. Is blood neutrophil-lymphocyte ratio an independent predictor of knee osteoarthritis severity? Clin Rheumatol 2016;35:1579-83. doi: 10.1007\/s10067-016-3170-8.","DOI":"10.1007\/s10067-016-3170-8"},{"key":"ref-15","doi-asserted-by":"crossref","unstructured":"Coleman S, Briffa NK, Carroll G, Inderjeeth C, Cook N, McQuade J. A randomised controlled trial of a selfmanagement education program for osteoarthritis of the knee delivered by health care professionals. Arthritis Res Ther 2012;14:R21. doi: 10.1186\/ar3703.","DOI":"10.1186\/ar3703"},{"key":"ref-16","doi-asserted-by":"crossref","unstructured":"Gao K, Zhang Y, Sun S, Lin B, Liu W, Lai W, et al. Novel inflammatory markers in the blood of patients with knee synovitis. J Int Med Res 2021;49:3000605211029557. doi: 10.1177\/03000605211029557.","DOI":"10.1177\/03000605211029557"},{"key":"ref-17","doi-asserted-by":"crossref","unstructured":"Benito MJ, Veale DJ, FitzGerald O, van den Berg WB, Bresnihan B. Synovial tissue inflammation in early and late osteoarthritis. 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Relationship between monocytes to lymphocytes ratio and axial spondyloarthritis. Int Immunopharmacol 2018;57:43-6. doi: 10.1016\/j.intimp.2018.02.008.","DOI":"10.1016\/j.intimp.2018.02.008"},{"key":"ref-21","doi-asserted-by":"crossref","unstructured":"Sargin G, Senturk T, Yavasoglu I, Kose R. Relationship between neutrophil-lymphocyte, platelet-lymphocyte ratio and disease activity in rheumatoid arthritis treated with rituximab. Int J Rheum Dis 2018;21:2122-7. doi: 10.1111\/1756-185X.13400.","DOI":"10.1111\/1756-185X.13400"},{"key":"ref-22","doi-asserted-by":"crossref","unstructured":"Song H, Jeong MJ, Cha J, Lee JS, Yoo JG, Song MJ, et al. Preoperative neutrophil-to-lymphocyte, plateletto-lymphocyte and monocyte-to-lymphocyte ratio as a prognostic factor in non-endometrioid endometrial cancer. 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J Neuroinflammation 2021;18:51. doi: 10.1186\/s12974-021-02090-6.","DOI":"10.1186\/s12974-021-02090-6"},{"key":"ref-25","doi-asserted-by":"crossref","unstructured":"\u015eener G, Bayrak T, Co\u015fkun C, Bayrak A. Neutrophil lymphocyte ratio, monocyte lymphocyte ratio, platelet lymphocyte ratio in Covid-19 patients. Clin Lab 2022;68. doi: 10.7754\/Clin.Lab.2021.210639.","DOI":"10.7754\/Clin.Lab.2021.210639"},{"key":"ref-26","doi-asserted-by":"crossref","unstructured":"Li S, Li X, Zhou W, Jiang Y, Jin M, Wang J. The value of hematological indexes in evaluating the risk of hip involvement in patients with ankylosing spondylitis. Clin Lab 2023;69. doi: 10.7754\/Clin.Lab.2022.220836.","DOI":"10.7754\/Clin.Lab.2022.220836"},{"key":"ref-27","unstructured":"Uysal A, Guntel M, Demetg\u00fcl \u00d6, \u00c7i\u00e7ek U. Ultrasonographic evaluation of the distal femoral cartilage thickness in Parkinson's patients. J Musculoskelet Neuronal Interact 2023;23:328-37."},{"key":"ref-28","doi-asserted-by":"crossref","unstructured":"B\u00fcy\u00fckavc\u0131 R, Akt\u00fcrk S, Sa\u011f S. Comparison of blood platelet distribution width and neutrophil-lymphocyte ratio in patients with different grades of knee osteoarthritis. J Back Musculoskelet Rehabil 2018;31:1035-9. doi: 10.3233\/BMR-171028.","DOI":"10.3233\/BMR-171028"},{"key":"ref-29","doi-asserted-by":"crossref","unstructured":"Shi J, Zhao W, Ying H, Du J, Chen J, Chen S, et al. The relationship of platelet to lymphocyte ratio and neutrophil to monocyte ratio to radiographic grades of knee osteoarthritis. Z Rheumatol 2018;77:533-7. doi: 10.1007\/ s00393-017-0348-7.","DOI":"10.1007\/s00393-017-0348-7"},{"key":"ref-30","doi-asserted-by":"crossref","unstructured":"Ta\u015fo\u011flu \u00d6, \u015eahin A, Karata\u015f G, Koyuncu E, Ta\u015fo\u011flu \u0130, Tecimel O, et al. Blood mean platelet volume and platelet lymphocyte ratio as new predictors of hip osteoarthritis severity. Medicine (Baltimore) 2017;96:e6073. doi: 10.1097\/ MD.0000000000006073.","DOI":"10.1097\/MD.0000000000006073"},{"key":"ref-31","doi-asserted-by":"crossref","unstructured":"Jaime P, Garc\u00eda-Guerrero N, Estella R, Pardo J, Garc\u00eda\u00c1lvarez F, Martinez-Lostao L. CD56+\/CD16- Natural Killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis. Osteoarthritis Cartilage 2017;25:1708-18. doi: 10.1016\/j. joca.2017.06.007.","DOI":"10.1016\/j.joca.2017.06.007"},{"key":"ref-32","doi-asserted-by":"crossref","unstructured":"Duran TI, Pamukcu M. Relationship between disease impact scores and C-reactive protein\/albumin ratio in patients with psoriatic arthritis. Croat Med J 2022;63:141-7. doi: 10.3325\/cmj.2022.63.141.","DOI":"10.3325\/cmj.2022.63.141"},{"key":"ref-33","doi-asserted-by":"crossref","unstructured":"Yang WM, Zhang WH, Ying HQ, Xu YM, Zhang J, Min QH, et al. Two new inflammatory markers associated with disease activity score-28 in patients with rheumatoid arthritis: Albumin to fibrinogen ratio and C-reactive protein to albumin ratio. Int Immunopharmacol 2018;62:293-8. doi: 10.1016\/j.intimp.2018.07.007.","DOI":"10.1016\/j.intimp.2018.07.007"},{"key":"ref-34","doi-asserted-by":"crossref","unstructured":"Bozkurt E, Muhafiz E, Sengul D, U\u00e7ak T, Atum M. Can the CRP\/albumin ratio be used as a new indicator of activation in patients with uveitis? Ocul Immunol Inflamm 2021;29:1017-22. doi: 10.1080\/09273948.2020.1714061.","DOI":"10.1080\/09273948.2020.1714061"},{"key":"ref-35","unstructured":"Yigit \u015e, Akar MS, \u015eahin MA, Arslan H. Periprosthetic infection risks and predictive value of C-reactive protein \/ albumin ratio for total joint arthroplasty. Acta Biomed 2021;92:e2021324. doi: 10.23750\/abm.v92i4.10995."},{"key":"ref-36","doi-asserted-by":"crossref","unstructured":"Mermerci Ba\u015fkan B, Yurdakul FG, Ayd\u0131n E, Sivas F, Bodur H. Effect of vitamin D levels on radiographic knee osteoarthritis and functional status. 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