{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:21:54Z","timestamp":1783066914268,"version":"3.54.6"},"reference-count":21,"publisher":"Galenos Yayinevi","issue":"3","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Turk J Phys Med Rehab"],"accepted":{"date-parts":[[2024,11,14]]},"published-print":{"date-parts":[[2025,9,1]]},"abstract":"<jats:p>\n                    <jats:bold>Objectives:<\/jats:bold>\n                    This study aimed to explore the clinical efficacy of acupuncture therapy combined with breathing training in patients with stroke complicated with pulmonary infection.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Patients and methods:<\/jats:bold>\n                    In this prospective randomized controlled study, a total of 72 patients with pulmonary infection after stroke who were admitted between May 2020 and May 2021 were randomly divided into the intervention group (n=36; 28 males, 8 females; mean age: 59.9\u00b113.4 years; range, 28 to 80 years) and the control group (n=36; 23 males, 13 females; mean age: 57.8\u00b112.2 years; range, 35 to 79 years). Both groups were treated with conventional drug therapy, rehabilitation therapy, and breathing training for two consecutive weeks. The intervention group additionally received acupuncture therapy. The following data was collected to evaluate clinical efficacy: the traditional Chinese medicine syndrome score and the clinical pulmonary infection score before and after treatment, inflammatory factors, time of symptom disappearance, and pulmonary indexes.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    After treatment, the traditional Chinese medicine syndrome score and the clinical pulmonary infection score were significantly lower in the intervention group than in the control group (both p&lt;0.05). The intervention group also experienced earlier fever resolution and faster disappearance of cough, expectoration, and moist rales in the lungs than the control group (all p&lt;0.05). Furthermore, white blood cell count, C-reactive protein, and calcitonin levels were significantly lower in the intervention group than in the control group (all p&lt;0.05). The total effective rates of the intervention group and control group were 94.44% (n=34) and 77.78% (n=28), respectively (chi-squared = 4.181, p=0.041). Additionally, forced vital capacity, forced expiratory volume in the first second, and peak expiratory flow were significantly higher in the intervention group than in the control group (all p&lt;0.05).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Acupuncture therapy combined with breathing training achieved high efficacy in patients with stroke complicated with pulmonary infection. It may improve the symptoms of pulmonary infection and suppress inflammatory responses.\n                  <\/jats:p>","DOI":"10.5606\/tftrd.2025.15201","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:35:36Z","timestamp":1757918136000},"page":"295-303","source":"Crossref","is-referenced-by-count":0,"title":["The impact of acupuncture therapy combined with breathing training on patients with stroke complicated with pulmonary infection: A prospective randomized controlled study"],"prefix":"10.4274","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3227-1695","authenticated-orcid":false,"given":"Hong-Lian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4472-8063","authenticated-orcid":false,"given":"Yu-Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5682-150X","authenticated-orcid":false,"given":"Jian-Yong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8388-8235","authenticated-orcid":false,"given":"Na","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0585-8084","authenticated-orcid":false,"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2811","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"ref-1","doi-asserted-by":"crossref","unstructured":"Debette S, Markus HS. Stroke genetics: Discovery, insight \u0131nto mechanisms, and clinical perspectives. Circ Res 2022;130:1095-111. doi: 10.1161\/CIRCRESAHA.122.319950.","DOI":"10.1161\/CIRCRESAHA.122.319950"},{"key":"ref-2","doi-asserted-by":"crossref","unstructured":"You Q, Bai D, Wu C, Wang H, Chen X, Gao J, et al. Risk factors for pulmonary infection in elderly patients with acute stroke: A meta-analysis. Heliyon 2022;8:e11664. doi: 10.1016\/j.heliyon.2022.e11664.","DOI":"10.1016\/j.heliyon.2022.e11664"},{"key":"ref-3","doi-asserted-by":"crossref","unstructured":"Shen TC, Lin CY, Lin CL, Chen CH, Tu CY, Hsia TC, et al. Risk of developing pleural empyema in patients with stroke: a propensity-matched cohort study. Intern Emerg Med 2017;12:1131-8.","DOI":"10.1007\/s11739-017-1707-8"},{"key":"ref-4","doi-asserted-by":"crossref","unstructured":"Zheng L, Wen L, Lei W, Ning Z. Added value of systemic inflammation markers in predicting pulmonary infection in stroke patients: A retrospective study by machine learning analysis. Medicine (Baltimore) 2021;100:e28439. doi: 10.1097\/MD.0000000000028439.","DOI":"10.1097\/MD.0000000000028439"},{"key":"ref-5","doi-asserted-by":"crossref","unstructured":"Yoo HJ, Pyun SB. Efficacy of bedside respiratory muscle training in patients with stroke: A randomized controlled trial. Am J Phys Med Rehabil 2018;97:691-7. doi: 10.1097\/ PHM.0000000000000933.","DOI":"10.1097\/PHM.0000000000000933"},{"key":"ref-6","doi-asserted-by":"crossref","unstructured":"Lai F, Ren Y, Lai C, Chen R, Yin X, Tan C, et al. Acupuncture at Zusanli (ST36) for experimental sepsis: A systematic review. Evid Based Complement Alternat Med 2020;2020:3620741. doi: 10.1155\/2020\/3620741.","DOI":"10.1155\/2020\/3620741"},{"key":"ref-7","doi-asserted-by":"crossref","unstructured":"Pan WX, Fan AY, Chen S, Alemi SF. Acupuncture modulates immunity in sepsis: Toward a science-based protocol. Auton Neurosci 2021;232:102793. doi: 10.1016\/j. autneu.2021.102793.","DOI":"10.1016\/j.autneu.2021.102793"},{"key":"ref-8","unstructured":"Neurology Branch of Chinese Medical Association. Classification of cerebrovascular diseases in China (2015). Chin. J Neurol 2017;50:168-171."},{"key":"ref-9","unstructured":"Infection Group of the Branch of Respiratory Disease, Chinese Medical Association. Chinese Guidelines for the Diagnosis and Treatment of Hospital-acquired Pneumonia and Ventilator-associated Pneumonia in Adults (2018 Edition). Chin J Tuberc Respir Dis 2018;41:255-80."},{"key":"ref-10","unstructured":"Guozhen Z, Xingyu Z, Xueyao Z. Interpretation of the General Rules for the Revision of Traditional Chinese Medicine Diagnosis and Therapeutic Effect Evaluation Standards. Chin J Basic Tradit Chin Med 2024,30:1294-7. doi: 10.19945\/j.cnki.issn.1006-3250.2024.08.014."},{"key":"ref-11","doi-asserted-by":"crossref","unstructured":"Fartoukh M, Maitre B, Honor\u00e9 S, Cerf C, Zahar JR, BrunBuisson C. Diagnosing pneumonia during mechanical ventilation: The clinical pulmonary infection score revisited. Am J Respir Crit Care Med 2003;168:173-9. doi: 10.1164\/rccm.200212-1449OC.","DOI":"10.1164\/rccm.200212-1449OC"},{"key":"ref-12","doi-asserted-by":"crossref","unstructured":"Zilberberg MD, Shorr AF. Ventilator-associated pneumonia: The clinical pulmonary infection score as a surrogate for diagnostics and outcome. Clin Infect Dis 2010;51 Suppl 1:S131-5. doi: 10.1086\/653062.","DOI":"10.1086\/653062"},{"key":"ref-13","doi-asserted-by":"crossref","unstructured":"Menezes KK, Nascimento LR, Ada L, Polese JC, Avelino PR, Teixeira-Salmela LF. Respiratory muscle training increases respiratory muscle strength and reduces respiratory  complications after stroke: A systematic review. J Physiother 2016;62:138-44. doi: 10.1016\/j.jphys.2016.05.014.","DOI":"10.1016\/j.jphys.2016.05.014"},{"key":"ref-14","unstructured":"Chen Z, Wang W, Zhou X, Li C. Pulmonary rehabilitation exercises improve lung function and reduce pneumonia recurrence in stroke patients. J Stroke Cerebrovasc Dis 2021;30:105497."},{"key":"ref-15","unstructured":"Chen Qi. The influence of acupuncture combined with rehabilitation therapy on arterial blood gas indicators, respiratory index and prognosis of elderly patients with pulmonary infection after stroke [J]. Chin J Exp Clin Infect Dis (Electron Ed) 2019;13):334-9."},{"key":"ref-16","unstructured":"Chen S, He L, Gao X, Wang Y, Kang G, Feng L. Clinical observation on plum-blossom needle combined with rehabilitation training for hand spasm after stroke. Zhongguo Zhen Jiu 2018;38:799-802. doi: 10.13703\/j.0255- 2930.2018.08.001."},{"key":"ref-17","doi-asserted-by":"crossref","unstructured":"Wang LQ, Chen Z, Zhang K, Liang N, Yang GY, Lai L, et al. Zusanli (ST36) acupoint injection for diabetic peripheral neuropathy: A systematic review of randomized controlled  trials. J Altern Complement Med 2018;24:1138-49. doi: 10.1089\/acm.2018.0053.","DOI":"10.1089\/acm.2018.0053"},{"key":"ref-18","unstructured":"Xu L, Wang M, Li F, Yang J. Acupuncture combined with rehabilitation training for the limb spasm after stroke. Zhongguo Zhen Jiu 2017;37:696-700. doi: 10.13703\/j.0255- 2930.2017.07.004."},{"key":"ref-19","doi-asserted-by":"crossref","unstructured":"Oh JE, Kim SN. Anti-inflammatory effects of acupuncture at ST36 point: A literature review in animal studies. Front Immunol 2022;12:813748. doi: 10.3389\/fimmu.2021.813748.","DOI":"10.3389\/fimmu.2021.813748"},{"key":"ref-20","doi-asserted-by":"crossref","unstructured":"Wang J, Zhu F, Huang W, Yang C, Chen Z, Lei Y, et al. Acupuncture at ST36 ameliorates experimental autoimmune encephalomyelitis via affecting the function of B cells. Int Immunopharmacol 2023;123:110748. doi: 10.1016\/j.intimp.2023.110748.","DOI":"10.1016\/j.intimp.2023.110748"},{"key":"ref-21","doi-asserted-by":"crossref","unstructured":"Zhao P, Fu H, Cheng H, Zheng R, Yuan D, Yang J, et al. Acupuncture at ST36 alleviates the behavioral disorder of autistic rats by inhibiting TXNIP-mediated activation of NLRP3. J Neuropathol Exp Neurol 2022;81:127-34. doi: 10.1093\/jnen\/nlab132.","DOI":"10.1093\/jnen\/nlab132"}],"container-title":["Turkish Journal of Physical Medicine and Rehabilitation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ftrdergisi.com\/uploads\/pdf\/pdf_4596.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ftrdergisi.com\/uploads\/pdf\/pdf_4596.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:08:35Z","timestamp":1783066115000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ftrdergisi.com\/uploads\/pdf\/pdf_4596.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,22]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,9,1]]}},"URL":"https:\/\/doi.org\/10.5606\/tftrd.2025.15201","relation":{},"ISSN":["2587-1250"],"issn-type":[{"value":"2587-1250","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,22]]}}}